Search results for "integrative"
showing 10 items of 132 documents
Extraversion and performance approach goal orientation : An integrative approach to personality
2019
Abstract Research shows that extraversion is unrelated to performance approach goal orientation, both at the trait- and the state-level. However, since previous studies have either focused on the trait- or the state-level, such a conclusion may be premature. Building upon the idea that acting against one’s trait consumes self-control resources, we reason that within-person deviations from one’s level of trait extraversion might negatively relate to performance approach goal orientation. Using experience sampling data from 47 employees across 10 days (N = 307), we found that deviations from one’s trait extraversion levels are associated with lower levels of performance approach goal orientat…
Integrative strategy formation process and the management of complex work - a microorganizational analisys
2010
The goal of this study is to analyse how the strategy formation process takes place; studying the relevance of the integrative perspective and the use of the variables rationality, involvement and vision; Verifying the relationship between an integrative strategy formation process and the management of work and the consequences of this relationship in terms of performance, identifying the causes for a better fit; Also, verify the propositions that have been formulated and looking for new variables that could affect the relationship between strategic process and work management. It has been adopted a qualitative methodology through a study case. After the case analysis it has been identified…
Next-Generation Sequencing: Application in Liver Cancer—Past, Present and Future?
2012
Hepatocellular Carcinoma (HCC) is the third most deadly malignancy worldwide characterized by phenotypic and molecular heterogeneity. In the past two decades, advances in genomic analyses have formed a comprehensive understanding of different underlying pathobiological layers resulting in hepatocarcinogenesis. More recently, improvements of sophisticated next-generation sequencing (NGS) technologies have enabled complete and cost-efficient analyses of cancer genomes at a single nucleotide resolution and advanced into valuable tools in translational medicine. Although the use of NGS in human liver cancer is still in its infancy, great promise rests in the systematic integration of different …
Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with phosphate homeostasis.
2012
Familial idiopathic basal ganglia calcification (IBGC) is a genetic condition with a wide spectrum of neuropsychiatric symptoms, including parkinsonism and dementia. Here, we identified mutations in SLC20A2, encoding the type III sodium-dependent phosphate transporter 2 (PiT2), in IBGC-affected families of varied ancestry, and we observed significantly impaired phosphate transport activity for all assayed PiT2 mutants in Xenopus laevis oocytes. Our results implicate altered phosphate homeostasis in the etiology of IBGC.
From causal thinking to wisdom and spirituality: some perspectives on a growing research field in adult (cognitive) development
2015
This article concentrates on the latest international trends in the research on psychological development of adults, and especially on the development of cognition. The field of research has been very fragmented, and researchers have kept creating new models one after another to describe their own lines of thought and also seeking for empirical evidence for their models. This has created a rather equivocal picture of the phenomenon itself. The present article attempts to identify the historical roots of the field, and introduces descriptive factors that could conceptually determine the gist of the phenomenon. In this context we will discuss, mainly, research going back to Piaget and Perry, …
Aproximación holística versus aproximación comunicativa en la evaluación de la producción oral en inglés
2014
El propósito de este artículo es mostrar el rendimiento comunicativo en las simulaciones en inglés en dos grupos contrastivos: estudiantes adiestrados en enseñanza integrativa en contraste con los que están siguiendo un curso de enfoque comunicativo. La evaluación de la producción oral mediante una aproximación por tareas a las actividades de simulación muestra que, aunque los estudiantes siguiendo el método comunicativo dominan mejor tales técnicas, los estudiantes del método integrativo son más aventajados en el dominio de la gramática. Sin embargo, la nota media de los alumnos del método integral no se encuentra demasiado alejada de la de los que han seguido el método comunicativo. La ra…
Phylogenetic position of two Macrobiotus species with a revisional note on Macrobiotus sottilei Pilato, Kiosya, Lisi & Sabella, 2012 (Tardigr…
2021
In a moss and lichen sample collected on the Polish coast, a new population of Macrobiotus sottilei was found. Given that the original description of M. sottilei was based solely on the morphology observed under light microscopy and measurements of a few individuals, we provide, by means of integrative taxonomy, a revisional note on this species. We present a comprehensive set of morphometric and morphological data from light and scanning electron microscopy analysis together with nucleotide sequences of three nuclear (18S rRNA, 28S rRNA, ITS-2) and one mitochondrial (COI) DNA fragments. We also provide the same set of DNA sequences for Macrobiotus glebkai from a population recently found i…
Poor transcript-protein correlation in the brain: negatively correlating gene products reveal neuronal polarity as a potential cause
2018
Transcription, translation, and turnover of transcripts and proteins are essential for cellular function. The contribution of those factors to protein levels is under debate, as transcript levels and cognate protein levels do not necessarily correlate due to regulation of translation and protein turnover. Here we propose neuronal polarity as a third factor that is particularly evident in the CNS, leading to considerable distances between somata and axon terminals. Consequently, transcript levels may negatively correlate with cognate protein levels in CNS regions, i.e., transcript and protein levels behave reciprocally. To test this hypothesis, we performed an integrative inter-omics study a…
Loss of all three APP family members during development impairs synaptic function and plasticity, disrupts learning, and causes an autism-like phenot…
2021
The key role of APP for Alzheimer pathogenesis is well established. However, perinatal lethality of germline knockout mice lacking the entire APP family has so far precluded the analysis of its physiological functions for the developing and adult brain. Here, we generated conditional APP/APLP1/APLP2 triple KO (cTKO) mice lacking the APP family in excitatory forebrain neurons from embryonic day 11.5 onwards. NexCre cTKO mice showed altered brain morphology with agenesis of the corpus callosum and disrupted hippocampal lamination. Further, NexCre cTKOs revealed reduced basal synaptic transmission and drastically reduced long-term potentiation that was associated with reduced dendritic length …
Impaired semantic processing during sentence reading in children with dyslexia: combined fMRI and ERP evidence
2008
Developmental dyslexia is a specific disorder of reading acquisition characterized by a phonological core deficit. Sentence reading is also impaired in dyslexic readers, but whether semantic processing deficits contribute is unclear. Combining spatially and temporally sensitive neuroimaging techniques to focus on semantic processing can provide a more comprehensive characterization of sentence reading in dyslexia. We recorded brain activity from 52 children (16 with dyslexia, 31 controls) with functional magnetic resonance imaging (fMRI) and event-related potentials (ERP) in two separate counterbalanced sessions. The children silently read and occasionally judged simple sentences with seman…