Search results for "interchangeability"
showing 6 items of 6 documents
Can life be standardized? Current challenges in biological standardization
2021
The concept of standard strongly evokes machines, industries, electric or mechanical devices, vehicles, or furniture. Indeed, our technological civilization would not be possible – at least in the terms it is structured today – without universal, reliable components, whose acknowledged use results in competitive costs, robustness and interchangeability. For example, an Ikea screw can be used in a wide set of structurally dissimilar furniture and an app can be run on many different smartphones. The very concept of standardization is linked to the industrial revolution and mass production of goods through assembly lines. The question we will try to answer in the present paper is the extent to…
Interchangeability among five devices that measure anterior eye distances.
2014
The aim was to study the interchangeability of various devices that measure anterior chamber depth (ACD) and white-to-white (WTW) distance.Eighty right eyes of eighty patients aged 20 to 40 years were included. Their spherical equivalent ranged from -4.25 to +1.00 dioptres. Each eye's ACD and the WTW distance were measured using the following devices: a Castroviejo surgical calliper, CA-200F Corneal Analyser, Orbscan II, Pentacam HR and IOLMaster 500.The Pentacam HR measured significantly greater ACD (p0.01) than the other two devices, whereas IOLMaster 500 and Orbscan II yielded comparable (p0.01) distances. Nonetheless, in every device comparison, the mean difference was within clinically…
Pharmacy and pharmacology of biosimilars
2008
Biosimilar medicines are biological medicinal products that can obtain a marketing authorization in the EU after the original product (biological reference medicine) has run out of patent. As a prerequisite, studies including clinical trials are to be conducted to compare the quality, safety, and efficacy of the biosimilar and reference medicine. Due to the specific characteristics of biopharmaceuticals like complex 3-dimensional (glyco) protein structure, immunogenicity, production in living organisms, which causes heterogeneity, complex manufacturing process and analysis, interchangeability of the biosimilar with its reference drug product is not guaranteed. In addition, INN (internationa…
Compatibility of the Different Tuning Systems in an Orchestra
2009
Focusing on the daily practice of musicians, we give flexibility to the mathematical treatment of musical notes, tuning systems and the relations between them. This allows us to connect the theory and the practice of music. Using the techniques of fuzzy logic, we describe the concepts with fuzzy sets and introduce the α-compatibility as a degree of interchangeability between tuning systems. To show how our proposal works, we use a fragment of Haydn and analyze the compatibility of the notes taken from 48 recordings for the tuning systems of Pythagoras, Zarlino and Equal Temperament of 12 notes.
Real life hexavalent vaccination among children as a practical guide for public health professionals: Four years (from 2016 to 2019) of clinical prac…
2022
Hexavalent (HV) vaccination is a priority for newborn protection and in Italy is included in the National Immunization Plan with a three doses cycle at 61, 121 and 301 days of age. A retrospective clinical study has been conducted to evaluate real life clinical practice of HV vaccination in the fourth most populous Italian Region. Data on the completion of the HV cycle, on the interchangeability between the two HV adopted in 2016–2017 (DTaP3-IPV-HB/Hib) and 2018–2019 (DTaP5-IPV-HB-Hib) and on the use above the established age, were collected in five Sicilian Local Health Authorities. Data showed an average 91.5% completion of the vaccination cycle at 24 months of age. The average age of adm…
On Interchangeability of Probe-Object Roles in Quantum-Quantum Interaction-Free Measurement
2019
In this paper we examine Interaction-free measurement (IFM) where both the probe and the object are quantum particles. We argue that in this case the description of the measurement procedure must by symmetrical with respect to interchange of the roles of probe and object. A thought experiment is being suggested that helps to determine what does and what doesn't happen to the state of the particles in such a setup. It seems that unlike the case of classical object, here the state of both the probe and the object must change. A possible explanation of this might be that the probe and the object form an entangled pair as a result of non-interaction.