Search results for "interference"
showing 10 items of 573 documents
miR-20b modulates VEGF expression by targeting HIF-1 alpha and STAT3 in MCF-7 breast cancer cells.
2010
MicroRNAs (miRNAs) are small non-coding RNAs that regulate the expression of different genes, including genes involved in cancer progression. A functional link between hypoxia, a key feature of the tumor microenvironment, and miRNA expression has been documented. We investigated whether and how miR-20b can regulate the expression of vascular endothelial growth factor (VEGF) in MCF-7 breast cancer cells under normoxic and hypoxia-mimicking conditions (CoCl(2) exposure). Using immunoblotting, ELISA, and quantitative real-time PCR, we demonstrated that miR-20b decreased VEGF protein levels at 4 and 24 h following CoCl(2) treatment, and VEGF mRNA at 4 h of treatment. In addition, miR-20b reduce…
Optimization of surface plasmons launching from subwavelength hole arrays: modelling and experiments
2009
International audience; The launching of surface plasmons by micro-gratings of subwavelength apertures milled in a thick metal film is important for the development of surface plasmon based circuits. By comparing the near-field optical images of such surface plasmon sources with the results of a Huygens-Fresnel principle based scattering model, we show that the properties of the locally launched SP beams such as divergence or uniformity can be tuned by adjusting the shape of the micro-gratings. This allows us to propose an optimized source array well adapted for providing a narrow, collimated and uniform beam. (c) 2007 Optical Society of America.
Reaction-diffusion on dynamic inhibition areas: A bio-inspired link scheduling algorithm
2014
We present the Dynamic Inhibition Areas Reaction-Diffusion (DIA-RD) algorithm, a distributed medium access control protocol that globally maximizes the spatial reusability (number of simultaneous transmissions per unit area) of wireless sensor networks. This algorithm is able, in consequence, to minimize the number of time slots needed to schedule the set of demanded links, making it very efficient to solve the Shortest Link Schedule problem. DIA-RD combines accurate interference management, provided by the use of dynamic inhibition areas based on the physical interference model; and global intelligent behavior, provided by the bio-inspired technique known as Reaction-Diffusion. This techni…
Functional design of power-split CVTs: An uncoupled hierarchical optimized model
2017
Abstract This paper provides a new model for the preliminary design of compound power-split CVTs. Unlike the existing models, the presented method allows the engineers to prioritize functionality and efficiency of the transmission, while delaying the choice of the involved gear sets’ layout as long as possible. The design approach follows a specific priority order, and each step deals with one particular issue, without mutual interference. A smart design-chart eases the assessment and the comparison of the only eligible alternatives, and eventually leads to a final feasible constructive scheme, which can be an excellent concept for further optimization and implementation. Moreover, the mode…
Multi-beam cooperative frequency reuse for coordinated multi-point transmission
2010
Coordinated multi-point (CoMP) joint transmission is considered in the 3rd generation partnership project (3GPP) long term evolution (LTE)-advanced as a key technique to mitigate inter-cell interference and improve the cell-edge performance. To effectively apply CoMP joint transmission, efficient frequency reuse schemes need to be designed to support resource management cooperation among coordinated cells. However, most of the existing frequency reuse schemes are not suitable for CoMP systems due to not considering multi-point joint transmission scenarios in their frequency reuse rules. In addition, the restrictions of frequency resources in those schemes result in a high blocking probabili…
DNA damage causes TP53-dependent coupling of self-renewal and senescence pathways in embryonal carcinoma cells.
2013
Recent studies have highlighted an apparently paradoxical link between self-renewal and senescence triggered by DNA damage in certain cell types. In addition, the finding that TP53 can suppress senescence has caused a re-evaluation of its functional role in regulating these outcomes. To investigate these phenomena and their relationship to pluripotency and senescence, we examined the response of the TP53-competent embryonal carcinoma (EC) cell line PA-1 to etoposide-induced DNA damage. Nuclear POU5F1/OCT4A and P21CIP1 were upregulated in the same cells following etoposide-induced G 2M arrest. However, while accumulating in the karyosol, the amount of OCT4A was reduced in the chromatin fract…
Effects of low-gamma tACS on primary motor cortex in implicit motor learning
2019
Abstract In the primary motor cortex (M1), rhythmic activity in the gamma frequency band has been found during movement planning, onset and execution. Although the role of high-gamma oscillatory activity in M1 is well established, the contribution of low-gamma activity is still unexplored. In this study, transcranial alternating current stimulation (tACS) was used with the aim to specifically modulate low-gamma frequency band in M1, during an implicit motor learning task. A 40 Hz-tACS was applied over the left M1 while participants performed a serial reaction time task (SRTT) using their right hand. The task required the repetitive execution of sequential movements in response to sequences …