Search results for "interferometry"

An Experimental Toolbox for Structure‐Based Hit Discovery for P. aeruginosa FabF, a Promising Target for Antibiotics

2021

Abstract FabF (3‐oxoacyl‐[acyl‐carrier‐protein] synthase 2), which catalyses the rate limiting condensation reaction in the fatty acid synthesis II pathway, is an attractive target for new antibiotics. Here, we focus on FabF from P. aeruginosa (PaFabF) as antibiotics against this pathogen are urgently needed. To facilitate exploration of this target we have set up an experimental toolbox consisting of binding assays using bio‐layer interferometry (BLI) as well as saturation transfer difference (STD) and WaterLOGSY NMR in addition to robust conditions for structure determination. The suitability of the toolbox to support structure‐based design of FabF inhibitors was demonstrated through the …

Synthesis of SWCNT Rings Made by Two Y Junctions and Possible Applications in Electron Interferometry

2007

Modeling of the role of conformational dynamics in kinetics of the antigen-antibody interaction in heterogeneous phase.

2012

[EN] A novel approach that may potentially be used to study biomolecular interactions including the simultaneous determination of structural and kinetic binding parameters is described in this Article for the first time. It allows a rigid distinction between the possible reaction mechanisms of biomolecular recognition, induced fit and conformational selection. The relative importance of the two pathways is determined not by comparing rate constants but the structural aspects of the interaction instead. So the exact location of antigen molecules with respect to the capture antibody is depicted experimentally, avoiding the use of X-ray crystallography. The proposed pattern is applied to study…

Effects of maxillary protraction determined by laser metrology

1990

In this work we studied some of the main effects of the maxillary protraction orthopedic device. The initial dento-craniofacial reactions induced by maxillary protraction similar to that commonly employed in clinical practice are reported. The fringe counting holographic interferometry technique is used to measure displacements. The experiments were performed on a dried human skull; traction application points were situated over the permanent lateral incisors or over the first permanent molars. The results fundamentally reveal an anterior rotation of the dentomaxillary complex, more intense when traction is applied to the lateral incisors, as shown by a more marked extrusion of the molars i…

VLBI-resolution radio-map algorithms: Performance analysis of different levels of data-sharing on multi-socket, multi-core architectures

2012

a b s t r a c t A broad area in astronomy focuses on simulating extragalactic objects based on Very Long Baseline Interferometry (VLBI) radio-maps. Several algorithms in this scope simulate what would be the observed radio-maps if emitted from a predefined extragalactic object. This work analyzes the performance and scaling of this kind of algorithms on multi-socket, multi-core architectures. In particular, we evaluate a sharing approach, a privatizing approach and a hybrid approach on systems with complex memory hierarchy that includes shared Last Level Cache (LLC). In addition, we investigate which manual processes can be systematized and then automated in future works. The experiments sh…

Dual-polarization-pump CW laser operation in Nd3+:LiNbO3 channel waveguides fabricated by reverse proton exchange

2008

Abstract In this work, continuous-wave laser action at 1084.5 nm at room temperature in LiNbO 3 :Nd 3+ channel waveguides, fabricated by reverse proton exchange (RPE), is reported. The sample was pumped at λ  = 808 nm in either σ or π-polarized configurations, TE- and TM-pumping schemes, being the laser emission π-polarized at all power levels. The laser characteristics, as function of the pumping scheme (TE or TM), have been obtained. In both cases, the laser emission was stable, without any reduction in the output power even under continuous pump operation at maximum power at room temperature, indicating high resistance to photorefractive damage.

Dual-Polarization Interferometry: A Novel Technique To Light up the Nanomolecular World

2015

[EN] The challenging lecture given in 1959 by physicist and Nobel Prize awarded R. P. Feynman: “There's plenty of room at the bottom” is considered to be the starting point for nanotechnology. With this peculiar title, Feynman encouraged researchers to explore beyond the atomic level and predicted exciting new phenomena that might revolutionize science and technology. Among these pioneering researchers are Eric Betzig, Stefan W. Hell and William E. Moerner, who have been awarded with the Nobel Prize in Chemistry 2014 for developing the super-resolved fluorescence microscopy. However, it is important to remark that the exploration of this amazing nanomolecular world began in the early 1980s …

Spatial Reconstruction Algorithm of DT Layer in Cryogenic Targets Using Optical Techniques

2007

The measurements of the solid DT layer, in terms of thickness and roughness, in the LMJ geometry (i.e. in a hohlraum) are not trivial. The DT layer measurements will be done using a Matsukov-Cassegrain telescope placed 39 cm away from the target. This telescope will be used to acquire shadowgraphy images on equators, and interferometric measurements on pole areas using optical coherence tomography (OCT). Optical coherence tomography allows determining the DT layer thickness on a few points, in the polar regions of the target. By scanning around the poles, several points can be acquired in order to calculate the roughness and the local shape of the DT layer at the pole. Both techniques were …

Charged kaon femtoscopic correlations inppcollisions ats=7  TeV

2013

Correlations of two charged identical kaons (KchKch) are measured in pp collisions at root s = 7 TeV by the ALICE experiment at the Large Hadron Collider (LHC). One-dimensional (KKch)-K-ch correlation functions are constructed in three multiplicity and four transverse momentum ranges. The (KKch)-K-ch femtoscopic source parameters R and lambda are extracted. The (KKch)-K-ch correlations show a slight increase of femtoscopic radii with increasing multiplicity and a slight decrease of radii with increasing transverse momentum. These trends are similar to the ones observed for pi pi and K-s(0) K-s(0) correlations in pp and heavy-ion collisions. However at high multiplicities, there is an indica…

Measurement of correlations between pions from different W's in e+e- → W+W- events

1997

Correlations between pions from different W's in e(+)e(-) --> W+W- events are studied using data collected by the DELPHI detector at LEP running at a centre-of-mass energy of 172 GeV in 1996. At the present level of statistics, no enhancement of the correlation function above that expected from a pair of uncorrelated W's is observed at small values of the four-momentum difference of the pions. (C) 1997 Published by Elsevier Science B.V.