Search results for "internet"
showing 10 items of 2589 documents
A web application for the unspecific detection of differentially expressed DNA regions in strand-specific expression data
2015
Abstract Genomic technologies allow laboratories to produce large-scale data sets, either through the use of next-generation sequencing or microarray platforms. To explore these data sets and obtain maximum value from the data, researchers view their results alongside all the known features of a given reference genome. To study transcriptional changes that occur under a given condition, researchers search for regions of the genome that are differentially expressed between different experimental conditions. In order to identify these regions several algorithms have been developed over the years, along with some bioinformatic platforms that enable their use. However, currently available appli…
DRUDIT: Web-based DRUgs DIscovery Tools to design small molecules as modulators of biological targets
2019
Abstract Motivation New in silico tools to predict biological affinities for input structures are presented. The tools are implemented in the DRUDIT (DRUgs DIscovery Tools) web service. The DRUDIT biological finder module is based on molecular descriptors that are calculated by the MOLDESTO (MOLecular DEScriptors TOol) software module developed by the same authors, which is able to calculate more than one thousand molecular descriptors. At this stage, DRUDIT includes 250 biological targets, but new external targets can be added. This feature extends the application scope of DRUDIT to several fields. Moreover, two more functions are implemented: the multi- and on/off-target tasks. These tool…
SKINK: a web server for string kernel based kink prediction in α-helices
2014
Abstract Motivation: The reasons for distortions from optimal α-helical geometry are widely unknown, but their influences on structural changes of proteins are significant. Hence, their prediction is a crucial problem in structural bioinformatics. Here, we present a new web server, called SKINK, for string kernel based kink prediction. Extending our previous study, we also annotate the most probable kink position in a given α-helix sequence. Availability and implementation: The SKINK web server is freely accessible at http://biows-inf.zdv.uni-mainz.de/skink. Moreover, SKINK is a module of the BALL software, also freely available at www.ballview.org. Contact: benny.kneissl@roche.com
RNA-Seq Atlas—a reference database for gene expression profiling in normal tissue by next-generation sequencing
2012
Abstract Motivation: Next-generation sequencing technology enables an entirely new perspective for clinical research and will speed up personalized medicine. In contrast to microarray-based approaches, RNA-Seq analysis provides a much more comprehensive and unbiased view of gene expression. Although the perspective is clear and the long-term success of this new technology obvious, bioinformatics resources making these data easily available especially to the biomedical research community are still evolving. Results: We have generated RNA-Seq Atlas, a web-based repository of RNA-Seq gene expression profiles and query tools. The website offers open and easy access to RNA-Seq gene expression pr…
Language does not modulate fake news credibility, but emotion does
2020
Abstract The proliferation of fake news in internet requires understanding which factors modulate their credibility and take actions to limit their impact. A number of recent studies have shown an effect of the foreign language when making decisions: reading in a foreign language engages a more rational, analytic mode of thinking (Costa et al., 2014, Cognition). This analytic mode of processing may lead to a decrease in the credibility of fake news. Here we conducted two experiments to examine whether fake news stories presented to university students were more credible in the native language than in a foreign language. Bayesian analyses in both experiments offered support for the hypothesi…
Designing Transport Supporting Services Together with Users with Intellectual Disabilities
2020
Transportation is an important yet challenging aspect in terms of mobility for persons with intellectual disabilities (ID). Despite positive implications of designing services with users, persons with ID are rarely given the opportunity to be involved in such design processes. In this action design research (ADR) study we involve persons with ID in the design through observations, photovoice interviews and in a staged, yet naturalistic user enactments on a bus. Our research contributes with design insights on transport supporting services and insights on user involvement of persons with ID in ADR. The three ADR cycles showed that people with ID is a heterogenous group of users and as such e…
A software tool via web for the statistical data analysis; R-php
2007
The spread of Internet and the growing demand of services from the web users have changed and are still changing the way to organize the work or the study. Nowadays, the main part of information and many services are on the web and the software is going toward the same direction: in fact, the use of software implemented via web is ever-increasing, with a client-server logic that enables the “centralized” use of software installed on a server. In this paper we describe the Structure and the running of R-php, an environment for statistical analysis, freely accessible and attainable through the World Wide Web, based on the statistical environment R. R-php is based on two modules: a base module…
The impact of user’s availability on On-line Ego Networks: a Facebook analysis
2016
We have defined and implemented a Facebook application to log a Facebook dataset.We have studied and validated the structural properties of the whole dataset and of the Dunbar ego networks.We have analyzed the interactions of the users.The availability of the users in the Dunbar ego networks have been investigated.Our results reveal the presence of the temporal homophily property in the Dunbar ego networks. Online Social Networks (OSNs) are the most popular applications in todays Internet and they have changed the way people interact with each other. Understanding the structural properties of OSNs and, in particular, how users behave when they connect to OSNs is crucial for designing user-c…
ProteinScanAR - An Augmented Reality Web Application for High School Education in Biomolecular Life Sciences
2012
Understanding protein structures is a crucial step in creating molecular insight for researchers as well as students and pupils. The enormous scaling gap between an atomic point of view and objects in daily life hampers developing an intuitive relation between them. Especially for high school students, it can be difficult to understand the spatial relations of a protein structure. Due to lack of direct imaging techniques, molecules can only be explored by studying abstract molecular models. Here, the use of Augmented reality (AR) techniques has proven to strongly improve structural perception. In this work we present ProteinScanAR, an augmented reality framework for biomolecular education t…
Wartość informacji w systemie informacyjnym w ocenie jej jakości
2018
The purpose of the article is to determine to what extent and how to evaluate the value of information available in the information system when assessing its quality. Such an evaluation, especially for systems operating on the Internet, is absolutely necessary because of the constant and rapid growth of the information resources available there, bearing the unnecessary economic costs of their poor quality and related to that negative social phenomena. The quality of information is a multidimensional category and requires evaluation of great number of different attributes. Are there among conceptual models for evaluating the quality of information also such that require evaluating the value …