Search results for "interpretation"

The Impact of the International Cooperation On Familial Hypercholesterolemia Screening and Treatment: Results from the ScreenPro FH Project

2019

Purpose of Review Familial hypercholesterolemia (FH) is often perceived and described as underdiagnosed and undertreated, though effective treatment of FH is available. Owing to the mentioned facts, it is ever more imperative to screen and treat FH patients. Subsequent to the identification of patients, the project focuses on the improvement of their prognoses. The ScreenPro FH project was established as a functional international network for the diagnosis, screening, and treatment of FH. Individual countries were assigned goals, e.g., to define the actual situation and available treatment. With “central support,” more centers and countries participated in the project. Subsequently, individ…

Per l'esegesi di Petr. Sat. 39.12

2006

Statistical inference in abstracts of 3 influential clinical pharmacology journals analysed using a text‐mining algorithm

2021

Aim To describe the trend in the prevalence of statistical inference in three influential clinical pharmacology journals METHODS: We applied a computer-based algorithm to abstracts of three clinical pharmacology journals published in 1976 to 2016 to identify statistical inference and its subtypes. Furthermore, we manually reviewed a random sample of 300 articles to access algorithm's performance in finding statistical inference in abstracts and as a screening tool for presence and absence of statistical inference in full text. Result The algorithm identified 59% (13,375/22,516 [mid p 95% CI, 59%-60%]) article abstracts with statistical inference. The percentage of abstracts with statistical…

Computer simulation of oxygen tension histograms--a possibility for interpretation of microelectrode measurements.

1972

Mit Sauerstoff-Mikroelektroden werden die lokalen Werte des Sauerstoffpartialdruckes im Mikrobereich der Organe gemessen und graphisch als Haufigkeitsverteilungen (Histogramme) dargestellt. Theoretisch wird der Einfluss der Kapillaranordnung (Gleich-, Gegenstromsystem und Kapillarnetzwerk) auf die Haufigkeitsverteilung der P02 Werte untersucht. Die fur zweidimensionale Modelle durchgefuhrte Analyse zeigt, dass Unterschiede in der Durchblutung, wie sie in den einzelnen Zweigen der Kapillarnetzwerke auftreten, einen starken Einfluss auf die Histogramme haben.

Two-stage adaptive designs with correlated test statistics.

2005

When performing a trial using an adaptive sequential design, it is usually assumed that the data for each stage come from different units; for example, patients. However, sometimes it is not possible to satisfy this condition or to check whether it is satisfied. In these cases, the test statistics and p-values of each stage may be dependent. In this paper we investigate the type I error of two-stage adaptive designs when the test statistics from the stages are assumed to be bivariate normal. Analytical considerations are performed under the restriction that the conditional error function is constant in the continuation region. We show that the decisions can become conservative as well as an…

Multivariate equivalence tests for use in pharmaceutical development.

2014

Statistical equivalence analyses are well-established parts of many studies in the biomedical sciences. Also in pharmaceutical development and manufacturing equivalence testing methods are required in order to statistically establish similarities between machines, process components, or complete processes. This article presents a choice of multivariate equivalence testing procedures for normally distributed data as generalizations of existing univariate methods. In all derived methods, variability is interpreted as nuisance parameter. The use of the proposed methods in pharmaceutical development is demonstrated with a comparative analysis of dissolution profiles.

Subjectivity as a Non-Textual Standard of Interpretation in the History of Philosophical Psychology

2008

Contemporary caution against anachronism in intellectual history, and the currently mo mentous theoretical emphasis on subjectivity in the philosophy of mind, are two prevailing conditions that set puzzling constraints for studies in the history of philosophical psychol ogy. The former urges against assuming ideas, motives, and concepts that are alien to the historical intellectual setting under study, and combined with the latter suggests caution in relying on our intuitions regarding subjectivity due to the historically contingent charac terizations it has attained in contemporary philosophy of mind. In the face of these condi tions, our paper raises a question of what we call non-textual…

Meeting the Discipline-Culture Framework of Physics Knowledge: A Teaching Experience in Italian Secondary School

2014

The paper deals with physics teaching/learning in high school. An investigation in three upper secondary school classes in Italy explored the reactions of students to a structuring lecture on optics within the discipline-culture (DC) framework that organises physics knowledge around four interrelated fundamental theories of light. The lecture presented optics as an unfolding conceptual discourse of physicists regarding the nature of light. Along with the knowledge constructed in a school course of a scientific lyceum, the students provided epistemological comments, displaying their perception of physics knowledge presented in the classroom. Students’ views and knowledge were investigated by…

¿Tiene arraigo en el cerebro la libertad?

2017

El artículo se propone, en primer lugar, ofrecer un nuevo concepto de naturaleza humana, más allá de la metafísica tradicional y de la interpretación naturalista de las actuales neurociencias, superando así la unilateral apropiación cientificista del concepto de naturaleza humana y defendiendo una biohermenéutica, que cuenta con la pluralidad de perspectivas para comprender la realidad humana, como en el dualismo epistémico habermasiano. En segundo lugar, se indaga si en el cerebro tiene arraigo la libertad en el sentido de «libre albedrío» y de «autonomía», teniendo en cuenta la posición de acreditados neurólogos y el estudio de las disposiciones naturales en la concepción kantiana de la a…

Sobre la noción de “forma de vida” en Wittgenstein

1970

En el artículo se analizan los pasajes más relevantes donde Wittgenstein emplea la expresión‘forma de vida’ (Lebensform), estableciendo conexiones entre sus diferentes sentidos. Acontinuación se exponen dos interpretaciones de esta noción –la orgánica y la cultural–, quealgunos autores consideran excluyentes entre sí, y se discute críticamente la unilateralidadde ambas interpretaciones y su status teórico. Finalmente, se propone una interpretaciónque permite compatibilizar trascendentalismo y naturalismo, habida cuenta de la funciónmetodológica que Wittgenstein atribuyó a la noción de ‘forma de vida’ en su análisisconceptual de las condiciones de la comprensión del lenguaje.