Search results for "interval"
showing 10 items of 1703 documents
A study of temporal estimation from the perspective of the Mental Clock Model.
2009
M. Cardaci's (2000) Mental Clock Model maintains that a task requiring a low mental workload is associated with an acceleration of perceived time, whereas a task requiring a high mental workload is associated with a deceleration. The authors examined the predictions of this model in a musical listening condition in which musical pieces were audible in several structural complexities. To measure the effects of musical complexity on time estimation, the authors used retrospective and prospective time-estimation paradigms. For the retrospective paradigm, the authors invited participants to listen to a musical piece and then estimate its duration. For the prospective paradigm, the authors invit…
Weighted-Average Least Squares (WALS): Confidence and Prediction Intervals
2022
We extend the results of De Luca et al. (2021) to inference for linear regression models based on weighted-average least squares (WALS), a frequentist model averaging approach with a Bayesian flavor. We concentrate on inference about a single focus parameter, interpreted as the causal effect of a policy or intervention, in the presence of a potentially large number of auxiliary parameters representing the nuisance component of the model. In our Monte Carlo simulations we compare the performance of WALS with that of several competing estimators, including the unrestricted least-squares estimator (with all auxiliary regressors) and the restricted least-squares estimator (with no auxiliary reg…
In-process tool-failure detection by means of AR models
1997
The present paper proposes a cutting tool breaking and chipping detection system for continuous and interrupted cutting, based on the analysis of the cutting force componentsFx andFy. A multifactorial experimental design has been carried out, to take account of the variability of the force signal. An adaptive signal processing algorithm is proposed, which detects catastrophic failure when at least one component deviates outside an estimated oscillation band for a time duration longer than a prefixed interval. The algorithm has been implemented on a four-microprocessor transputer board. Several tests confirmed the validity of the approach for detecting breaking and chipping phenomena in a fe…
Mutual Information Analysis of Brain-Heart Interactions in Epileptic Children
2021
In this work we apply the network physiology paradigm to retrieve information from central and autonomic nervous systems before focal epileptic seizure, represented respectively by electroencephalogram (EEG) signals and R-R intervals (RRI), and investigate on the presence and strength of brain-heart interactions by computing mutual information (MI) measures. Statistical significance of MI values was tested through surrogate time series generated with the random shuffle approach. Our results suggest that the proposed method for aligning signals representing brain and heart activity measured with different sampling rates, is capable of revealing coupling between RRI representing heart system,…
Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: Identification of two naturally occurring receptor variants and …
1996
A statistically significant association between a silent mutation (102T/C) in the serotonin-2A (5-HT2A) receptor gene and schizophrenia has recently been reported in a sample of Japanese patients and healthy controls. This finding suggests that genetic predisposition to schizophrenia may be affected by a functional 5-HT2A receptor variant that is in linkage disequilibrium with 102T/C. In the present study, we have sought to identify genetic variation in the 5-HT2A receptor gene by screening genomic DNA samples from 91 unrelated subjects comprising 45 patients with schizophrenia and 46 healthy controls by using single-strand conformation analysis. We have identified four nucleotide sequence …
Ten-year follow-up on efficacy, immunogenicity and safety of two doses of a combined measles-mumps-rubella-varicella vaccine or one dose of monovalen…
2020
Abstract Background We assessed the 10-year efficacy, immunogenicity and safety of two doses of a combined measles-mumps-rubella-varicella vaccine (MMRV) or one dose of a monovalent varicella vaccine (V) in children from Czech Republic, Lithuania, Poland, Romania and Slovakia. Methods This was a phase IIIB follow-up of an observer-blind, randomized, controlled trial (NCT00226499). In phase A, healthy children aged 12–22 months from 10 European countries were randomized in a 3:3:1 ratio to receive two doses of MMRV (MMRV group), one dose of MMR followed by one dose of V (MMR + V group), or two doses of MMR (MMR; control group), 42 days apart. Vaccine efficacy (VE) against varicella (confirme…
Anxiety and Covert Changes of Attention Control
1986
Publisher Summary This chapter presents a research paradigm, which allows the study of covert attentional processes in threatening situations and explores their relationship to the subjective experience of anxiety. These processes mediate changes of attention control beyond awareness by influencing the selective organization of behavior. The contingent negative variation (CNV) is a surface-negative slow potential that arises in the interstimulus interval of a forewarned reaction time task, where a warning signal (S1) precedes an imperative stimulus (S2), to which an overt motor response is required. If the interstimulus interval is shorter than approximately 3 seconds, CNV appears as a cont…
Predicting school students’ physical activity intentions in leisure-time and school recess contexts: Testing an integrated model based on self-determ…
2021
BackgroundIdentifying psychological correlates of children's physical activity intentions may signpost potentially modifiable targets for interventions aimed at promoting physical activity participation. School recess and leisure-time outside of school are appropriate contexts in which such interventions may be delivered. However, few studies have identified correlates of physical activity intentions in these environments. Examining correlates in these contexts may provide formative evidence on which to base interventions to promote physical activity.PurposeThe current study adopted an integrated theoretical model to test relations between motivational constructs from self-determination the…
What links BRAF to the heart function? new insights from the cardiotoxicity of BRAF inhibitors in cancer treatment
2015
The RAS-related signalling cascade has a fundamental role in cell. It activates differentiation and survival. It is particularly important one of its molecules, B-RAF. B-RAF has been a central point for research, especially in melanoma. Indeed, it lacked effective therapeutic weapons since the early years of its study. Molecules targeting B-RAF have been developed. Nowadays, two classes of molecules are approved by FDA. Multi-target molecules, such as Sorafenib and Regorafenib, and selective molecules, such as Vemurafenib and Dabrafenib. Many other molecules are still under investigation. Most of them are studied in phase 1 trials. Clinical studies correlate B-RAF inhibitors and QT prolonga…