Search results for "interval"

showing 10 items of 1703 documents

Validation of STA-Liatest D-Di assay for exclusion of pulmonary embolism according to the latest Clinical and Laboratory Standard Institute/Food and …

2017

: Combined clinical pretest probability (PTP) and D-dimer testing have great diagnostic value for pulmonary embolism exclusion. To harmonize performance levels of D-dimer assays available on the market, the Clinical and Laboratory Standard Institute (CLSI) has published a guideline, endorsed by the US Food and Drug Administration (FDA). Such guideline specifies the ideal D-dimer assay characteristic and target population. This study was conducted following the CLSI guideline to upgrade the assay-intended use and obtain FDA clearance of STA-Liatest D-Di assay for pulmonary embolism exclusion in patient with low/moderate PTP. This was an international, multicenter, prospective nonrandomized, …

MalePediatricsmedicine.medical_specialtypulmonary embolism030204 cardiovascular system & hematologyFood and drug administrationFibrin Fibrinogen Degradation Products03 medical and health sciences0302 clinical medicinemedicineHumans030212 general & internal medicineProspective StudiesSTA-Liatest D-Dibusiness.industryUnited States Food and Drug AdministrationClinical and Laboratory Standard InstituteFood and Drug AdministrationHematologyGeneral MedicineGuidelineOriginal ArticlesMiddle Agedmedicine.diseaseThrombosisConfidence intervalUnited StatesPulmonary embolismPre- and post-test probabilityD-dimerEmergency medicineAmbulatoryBiological AssayFemalebusinessVenous thromboembolismBlood coagulationfibrinolysis : an international journal in haemostasis and thrombosis
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Comparing Long-Acting Antipsychotic Discontinuation Rates Under Ordinary Clinical Circumstances: A Survival Analysis from an Observational, Pragmatic…

2021

Background Recent guidelines suggested a wider use of long-acting injectable antipsychotics (LAI) than previously, but naturalistic data on the consequences of LAI use in terms of discontinuation rates and associated factors are still sparse, making it hard for clinicians to be informed on plausible treatment courses. Objective Our objective was to assess, under real-world clinical circumstances, LAI discontinuation rates over a period of 12 months after a first prescription, reasons for discontinuation, and associated factors. Methods The STAR Network ‘Depot Study’ was a naturalistic, multicentre, observational prospective study that enrolled subjects initiating a LAI without restrictions …

MalePediatricsrespectively)0302 clinical medicineDelayed-Action PreparationBrief Psychiatric Rating ScalePharmacology (medical)he STAR Network ‘Depot Study’ prospectively followed 394 subjects initiating treatment with long-acting injections (LAIs) of antipsychotics under naturalistic conditions for 12 months. LAI discontinuation was frequent in everyday clinical practice in ItalyOriginal Research ArticleProspective StudiesProspective cohort studytreatmentMental DisordersHazard ratiowhereas more than half of participants initiating risperidone LAI and olanzapine LAI discontinued during the 12 months of follow-up (51.4 and 62.5%Psychiatric Status Rating ScaleMiddle Agedside efectsPsychiatry and Mental healthItalyMental DisorderFemalehe STAR Network ‘Depot Study’ prospectively followed 394 subjects initiating treatment with long-acting injections (LAIs) of antipsychotics under naturalistic conditions for 12 months. LAI discontinuation was frequent in everyday clinical practice in Italy occurring in almost 40% of the entire sample; side efects participant refusal to continue LAIs and LAIs no longer being required were the most frequently reported reasons for discontinuation. Paliperidone LAI and aripiprazole LAI were the least discontinued medications (33.9 and 35.4% respectively) whereas more than half of participants initiating risperidone LAI and olanzapine LAI discontinued during the 12 months of follow-up (51.4 and 62.5% respectively). In multivariate analysis being prescribed olanzapine LAI and poor medication adherence at baseline were signifcantly associated with higher discontinuation risk.HumanAntipsychotic Agentsmedicine.drugPsychopathologyAdultmedicine.medical_specialtyDiscontinuationFollow-Up StudieMedication Adherence03 medical and health sciencesmedicineHumansPaliperidoneAdverse effectSettore MED/25 - Psichiatriadiscontinuation ratesPsychiatric Status Rating Scalesrespectively). In multivariate analysisbusiness.industryLong-Acting Antipsychoticlong-acting injectable antipsychoticsSurvival AnalysisConfidence intervalparticipant refusal to continue LAIs and LAIs no longer being required were the most frequently reported reasons for discontinuation. Paliperidone LAI and aripiprazole LAI were the least discontinued medications (33.9 and 35.4%030227 psychiatryDiscontinuationProspective StudieAntipsychotic Agentoccurring in almost 40% of the entire sampleDelayed-Action PreparationsNeurology (clinical)business030217 neurology & neurosurgerybeing prescribed olanzapine LAI and poor medication adherence at baseline were signifcantly associated with higher discontinuation riskFollow-Up Studies
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Seasonality of suicide: a multi-country multi-community observational study.

2020

Aims We aimed to investigate the heterogeneity of seasonal suicide patterns among multiple geographically, demographically and socioeconomically diverse populations. Methods Weekly time-series data of suicide counts for 354 communities in 12 countries during 1986–2016 were analysed. Two-stage analysis was performed. In the first stage, a generalised linear model, including cyclic splines, was used to estimate seasonal patterns of suicide for each community. In the second stage, the community-specific seasonal patterns were combined for each country using meta-regression. In addition, the community-specific seasonal patterns were regressed onto community-level socioeconomic, demographic and …

MalePeriodicityHot TemperatureEpidemiologyClimate610 Medicine & healthTrough (economics)Suicide preventionsocioeconomicSocioeconomic360 Social problems & social servicesSeasonal suicide patternsmedicineHumansSex Distribution610 Medicine & healthSocioeconomic statusseasonalityPublic Health Environmental and Occupational HealthOriginal ArticlesSeasonalitymedicine.diseaseConfidence intervalCold TemperaturePsychiatry and Mental healthSuicideGeographySocioeconomic FactorsClimate; heterogeneity; seasonality; socioeconomic; suicide; Cold Temperature; Female; Hot Temperature; Humans; Male; Periodicity; Sex Distribution; Socioeconomic Factors; Suicide; SeasonsRelative riskObservational studyFemaleSeasonsheterogeneity360 Social problems & social servicesDemographyMulti country
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The effects of age at menarche and first sexual intercourse on reproductive and behavioural outcomes:A Mendelian randomization study

2020

SummaryThere is substantial variation in the timing of significant reproductive life events such as menarche and first sexual intercourse. Life history theory explains this variation as an adaptive response to the developmental environment. In environments characterized by harsh conditions, adopting a fast life history strategy may increase fitness. In line with this, there is evidence demonstrating that greater childhood adversity is associated with earlier age at menarche. Here we applied Mendelian randomization (MR) methods to investigate whether there is a causal effect of variation in age at menarche and age at first sexual intercourse on outcomes related to reproduction, education and…

MalePhysiologySocial SciencesFamilies0302 clinical medicineEndocrinologyMathematical and Statistical TechniquesSociologyReproductive PhysiologyPregnancyCopulationMedicine and Health SciencesPsychology030212 general & internal medicineChildrenLife History Traitsmedia_common0303 health sciencesMultidisciplinaryAlcohol ConsumptionReproductionStatisticsQAge FactorsCoitusRGenomicsMetaanalysisMiddle AgedCausalityPhysical SciencesMenarcheEducational StatusMedicineFemaleReproductionPsychologyResearch Articlemedia_common.quotation_subjectScienceAffect (psychology)Research and Analysis MethodsLife history theoryEducation03 medical and health sciencesRisk-TakingMendelian randomizationmedicineGenome-Wide Association StudiesGeneticsHumansSocial determinants of healthStatistical MethodsMenstrual CycleEducational Attainment030304 developmental biologyNutritionMenarchePregnancyBehaviorEndocrine PhysiologyBiology and Life SciencesComputational BiologyHuman GeneticsMendelian Randomization Analysismedicine.diseaseGenome AnalysisConfidence intervalEducational attainmentUnited KingdomDietSexual intercourseAge GroupsPeople and PlacesPopulation GroupingsMathematicsDemography
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Physical activity levels in adults and elderly from triaxial and uniaxial accelerometry. The Tromsø study

2019

Introduction - Surveillance of physical activity at the population level increases the knowledge on levels and trends of physical activity, which may support public health initiatives to promote physical activity. Physical activity assessed by accelerometry is challenged by varying data processing procedures, which influences the outcome. We aimed to describe the levels and prevalence estimates of physical activity, and to examine how triaxial and uniaxial accelerometry data influences these estimates, in a large population-based cohort of Norwegian adults. Methods - This cross-sectional study included 5918 women and men aged 40–84 years who participated in the seventh wave of the Tromsø St…

MalePopulation levelPhysiologyCross-sectional studySocial SciencesWalkingBody Mass Index0302 clinical medicineSociologyAccelerometryMedicine and Health SciencesMedicinePublic and Occupational Health030212 general & internal medicineSport and Fitness SciencesData ProcessingSchoolsMultidisciplinaryVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801IdrottsvetenskapNorwayQRMiddle AgedSports Science3. Good healthPhysiological ParametersCohortEngineering and TechnologyMedicineFemaleInformation TechnologyResearch ArticleComputer and Information Sciencesmedicine.medical_specialtySciencePhysical activityEducationWearable Electronic Devices03 medical and health sciencesAge DistributionHumansSports and Exercise MedicineExercise physiologyExerciseEducational AttainmentAgedSedentary timeBiological Locomotionbusiness.industryBody WeightBiology and Life SciencesPhysical Activity030229 sport sciencesConfidence intervalCross-Sectional StudiesPhysical FitnessPhysical therapySedentary BehaviorElectronicsAccelerometersVDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801businessBody mass indexhuman activities
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Systolic Blood Pressure Variation and Mean Heart Rate Is Associated With Cognitive Dysfunction in Patients With High Cardiovascular Risk

2015

Abstract— Elevated systolic blood pressure (SBP) correlates to cognitive decline and incident dementia. The effects of heart rate (HR), visit to visit HR variation, and visit to visit SBP variation are less well established. Patients without preexisting cognitive dysfunction (N=24 593) were evaluated according to mean SBP, SBP visit to visit variation (coefficient of variation [standard deviation/mean×100%], CV), mean HR, and visit to visit HR variation (HR-CV) in the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial and the Telmisartan Randomized Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease. Cognitive function was assessed with min…

MalePredictive Value of TestAngiotensin-Converting Enzyme InhibitorsBlood PressureBenzimidazoleBenzoatesRamiprilRetrospective StudieHeart RateRisk FactorsCardiovascular DiseaseTelmisartanCognitive declineMultivariate AnalysiRandomized Controlled Trials as TopicAged 80 and overmedicine.diagnostic_testIncidenceMiddle AgedstrokeAntihypertensive Agentmyocardial infarctionCardiovascular DiseasesHypertensionCardiologyDrug Therapy CombinationFemaleHumanmedicine.drugRamiprilmedicine.medical_specialtyBenzoateFollow-Up StudieCognition DisorderPredictive Value of TestsInternal medicineHeart rateInternal MedicinemedicineHumansDementiaAntihypertensive AgentsAgedRetrospective StudiesMini–Mental State Examinationbusiness.industryRisk FactorAngiotensin-Converting Enzyme InhibitorOdds ratiomedicine.diseaseConfidence intervalBlood pressureMultivariate AnalysisPhysical therapyBenzimidazolesCognition DisordersbusinessFollow-Up StudiesHypertension
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Norwegian version of the Nutritional Form for the Elderly: sufficient psychometric properties for performing institutional screening of elderly patie…

2009

The objective of this study was to test if the Norwegian version of the nutritional screening instrument entitled Nutritional Form for the Elderly (NUFFE-NO) demonstrates sufficient evidence of reliability and validity, including sensitivity and specificity, when applied to a select group of elderly hospital patients. The hypothesis was that NUFFE-NO has sufficient psychometric properties to be used as a screening instrument. The model used for the testing procedure was designed to test reliability (homogeneity and stability) and validity (criterion-related, concurrent validity, and construct validity) including sensitivity and specificity in a cross-sectional study. One-hundred fifty-eight…

MalePsychometricsCross-sectional studyEndocrinology Diabetes and MetabolismtverrsnittkartleggingEndocrinologySurveys and QuestionnairesMedicineernæringsstatusdrikkeAged 80 and overmåltidNutrition and DieteticsNorwayunderernæringtestingTest (assessment)NUFFE-NOFemalemedicine.medical_specialtyPsychometricsConcurrent validityNorgeDiet SurveysNutritional Form For the ElderlyforebyggingsykehusmatCronbach's alphatverrsnittstudieeldreHumansGeriatric AssessmentAgedpasientsikkerhetReceiver operating characteristiclivskvalitetbusiness.industryscreeningrisikoConstruct validityReproducibility of ResultsHealth SurveysConfidence intervalinstitusjonhelseCross-Sectional StudiesNutrition AssessmenternæringskartleggingPhysical therapyvalideringbusinessernæringNutrition research (New York, N.Y.)
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Reliability and Validity Study of the Finnish Adaptation of Scoliosis Research Society Questionnaire Version SRS-30

2017

Study design A prospective clinical study to test and adapt a Finnish version of the Scoliosis Research Society 30 (SRS-30) questionnaire. Objective The aim of this study was to perform cross-cultural adaptation and evaluate the validity of the adapted Finnish version of the SRS-30 questionnaire. Summary of background data The SRS-30 questionnaire has proved to be a valid instrument in evaluating health-related quality of life (HRQoL) in adolescent and adult population with spine deformities in the United States. Multinational availability requires cross-cultural and linguistic adaptation and validation of the instrument. Methods The SRS-30 was translated into Finnish using accepted methods…

MalePsychometricsIntraclass correlationRAND-36translationskolioosielämänlaatupatient outcome instrument0302 clinical medicineQuality of lifeScoliosis Research SocietySurveys and QuestionnairesMedicineHealth Status IndicatorsOrthopedics and Sports MedicineProspective StudiesOswestry disability indexFinlandreliabiliteetti030222 orthopedicsHealth Policyta3141Middle AgedOswestry Disability IndexScoliosisvalidointiCohortFemaleSpinal Diseasescross-cultural adaptationCross-Cultural Comparisonmedicine.medical_specialtyPsychometricsVisual analogue scalekyselytutkimusScoliosisHRQoL03 medical and health sciencesCronbach's alphaHumansSRS-30Agedreliabilitybusiness.industryadult spinal deformityFinnishPublic Health Environmental and Occupational HealthReproducibility of ResultsTranslatingmedicine.diseaseConfidence intervalvaliditeettiPhysical therapyQuality of LifeNeurology (clinical)business030217 neurology & neurosurgerySpine
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Correlates of mortality in elderly COPD patients: focus on health-related quality of life

2009

BACKGROUND AND OBJECTIVE: The Saint George Respiratory Questionnaire (SGRQ) is widely used as a measure of health-related quality of life (HRQL) in patients with COPD. This study tested whether the SGRQ predicts the survival of patients with COPD. METHODS: The study recruited 238 patients with COPD who were participants in the multicentre Salute Respiratoria nell'Anziano (Sa.R.A.) study. Patients' sociodemographic, clinical and functional characteristics were assessed and the association between the SGRQ and mortality, corrected for potential confounders, was estimated. RESULTS: The mean age of study participants was 72.6 years. Over the 5-year observation period there were 88 deaths. After…

MalePulmonary and Respiratory MedicinePediatricsmedicine.medical_specialtyCopd patientsSettore MED/10 - Malattie Dell'Apparato RespiratorioRisk AssessmentSeverity of Illness IndexPulmonary Disease Chronic ObstructiveQuality of lifePredictive Value of TestsSurveys and QuestionnairesHumansMedicineAgedProportional Hazards ModelsHealth related quality of lifeCOPDbusiness.industryHazard ratioConfoundingPrognosismedicine.diseaseHealth SurveysCOPD mortality health-related quality of life.Confidence intervalItalyQuality of LifeFemalebusinessLower mortality
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Pooled safety analysis of the fixed-dose combination of indacaterol and glycopyrronium (QVA149), its monocomponents, and tiotropium versus placebo in…

2014

BACKGROUND: To further assess the safety profile of the fixed-dose combination of indacaterol and glycopyrronium (QVA149) and its monocomponents; we investigated the impact of individual patient-level factors and time by integrating the patient-level safety data from the QVA149 clinical programme with relevant information from the independent indacaterol and glycopyrronium safety databases.METHODS: Data from 11,404 patients with chronic obstructive pulmonary disease (COPD) were pooled from 14 clinical studies of QVA149, indacaterol and glycopyrronium of ≥3 month's duration with at least two of the treatment groups: QVA149 110/50 μg, glycopyrronium 50 μg, indacaterol 150 μg, placebo or tiotr…

MalePulmonary and Respiratory Medicinemedicine.medical_specialtyFixed-dose combinationScopolamine DerivativesQuinolonesPlaceboPooled analysisPulmonary Disease Chronic ObstructiveRisk FactorsInternal medicinemedicineHumansTiotropium BromideIndacaterolAgedCOPDbusiness.industryTiotropiumHazard ratioQVA149Middle Agedmedicine.diseaseGlycopyrrolateConfidence intervalBronchodilator AgentsDrug CombinationsTreatment OutcomeAnesthesiaIndansIndacaterolDrug Therapy CombinationFemaleGlycopyrroniumSafetybusinessBody mass indexMacemedicine.drugRespiratory Medicine
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