Search results for "intolerance"
showing 7 items of 137 documents
Nenoteiktības nenoturības saistība ar elektrodermālās aktivitātes rādītājiem
2019
Darba mērķis bija noskaidrot, kāda saistība pastāv starp indivīda nenoteiktības nenoturību un elektrodermālo aktivitāti1) noteiktā un nenoteiktā situācijā, 2) neitrālu un negatīvu audiālo stimulu gadījumā, 3) gaidot situācijas iznākumu un pēc tās. Pētījumā piedalījās 25 dalībnieki, ar vidējo vecumu M = 24,62, SD = 4,42 gadi. Tika demonstrēta attēlu un skaņas signālu sērija, paralēli mērot elektrodermālo aktivitāti. Tika izmantota Nenoteiktības nenoturības 12 pantu skalu un DASS-21. Nenoteiktības nenoturības 12 pantu skalas iekšējā saskaņotība bija laba, bet konverģentā validitāte bija vāja. Tika secināts, ka indivīdiem ar augstāku nenoteiktības nenoturību, bija lielāka elektrodermālā aktivi…
Betatrophin Levels Are Related to the Early Histological Findings in Nonalcoholic Fatty Liver Disease
2021
Betatrophin, a liver hormone, regulates glucose and lipid metabolism. We investigated the betatrophin levels in nonalcoholic fatty liver disease (NAFLD) and searched for any relationship with histological severity and metabolic parameters. Fifty males with NAFLD [Nonalcoholic Steatohepatitis (NASH) (n = 32)
High-Fat Diet Induces Pre-Diabetes and Distinct Sex-Specific Metabolic Alterations in Negr1-Deficient Mice
2021
In the large GWAS studies, NEGR1 gene has been one of the most significant gene loci for body mass phenotype. The purpose of the current study was to clarify the role of NEGR1 in the maintenance of systemic metabolism, including glucose homeostasis, by using both male and female Negr1−/− mice receiving a standard or high fat diet (HFD). We found that 6 weeks of HFD leads to higher levels of blood glucose in Negr1−/− mice. In the glucose tolerance test, HFD induced phenotype difference only in male mice
Increased dosage of Ink4/Arf protects against glucose intolerance and insulin resistance associated with aging
2013
Recent genome-wide association studies have linked type-2 diabetes mellitus to a genomic region in chromosome 9p21 near the Ink4/Arf locus, which encodes tumor suppressors that are up-regulated in a variety of mammalian organs during aging. However, it is unclear whether the susceptibility to type-2 diabetes is associated with altered expression of the Ink4/Arf locus. In the present study, we investigated the role of Ink4/Arf in age-dependent alterations of insulin and glucose homeostasis using Super-Ink4/Arf mice which bear an extra copy of the entire Ink4/Arf locus. We find that, in contrast to age-matched wild-type controls, Super-Ink4/Arf mice do not develop glucose intolerance with agi…
Krūmiņa-Koņkova, Solveiga; Ruiz-Pereira, Sebastian; Peterson, Voltair Alvarado; Mazlovskis, Arnis; Leitlande, Gita; Mieriņa, Inta; Stašulāne, Anita;O…
2022
Reliģiski-filozofiski raksti XXXII ir par telpas pieredzēšanu: par to, kā mēs izdzīvojam sevi vietā, kurā esam, un kā mēs izjūtam sevi šajā savā vietā vai vietā, kura tā arī nav kļuvusi vai nekad nebūtu varējusi kļūt par mūsu dzīves pasauli. Kā veidojas šī savas vietas izjūta? Vai vieta, kurā mēs dzīvojam, vienmēr ir mājas? Vai šo vietas izjūtu veido mūsu individuālā pieredze vai varbūt tā ir vairāk atkarīga no kādām kolektīvām prasībām? Varbūt to nosaka mūsu piederība tradīcijām, kurās esam audzināti un kuras arī saucam par savām, bet varbūt tieši mūsu vietas pieredze ir tā, kas nosaka to, kādai tradīcijai mēs izvēlamies piederēt vai kuras veidošanā piedalāmies? Par tradīcijas iesakņošanos…
When other rules defend dissidents : the situation of Protestants and Orthodox Christians in the Polish - Lithuanian Commonwealth of the Saxon era
2018
The article address the problem of limiting the rights of Protestants and other non-Catholic Christian denominations during the reigns of two kings from the Wettin dynasty - King Augustus II (1697-1733). The process started as early as the second half of the 17th century, but it was fully accomplished in the years 1717-1736. In the article the author discussed the resolutions of the sejms and other legal acts introduced at that time, the aim of which was to eliminate dissenters from public life. The Polish monarchs were inert towards the process. It was the rulers of non - Catholic European states (Prussia, Russia and Great Britain) that helped Protestants an Orthodox Christans in Poland
Intolerance of Uncertainty and Risk Perception during the COVID-19 Pandemic: The Mediating Role of Fear of COVID-19
2022
The COVID-19 pandemic, a period of uncertainty and risk, has presented a threat to people’s physical and mental health worldwide. Previous research has shown that pandemic-related uncertainty can contribute to individuals’ psychological distress and coping responses. Therefore, the aim of this study was to investigate the relationship between intolerance of uncertainty and risk perception (i.e., individual’s perceived likelihood of becoming infected both for themselves and people in one’s own country and perceived severity of the infection), and the mediating role of fear of COVID-19. This two-wave longitudinal study (T1 = April 2020; T2 = May 2020) involved 486 youn…