Search results for "iom"
showing 10 items of 14211 documents
Thiazole Analogues of the Marine Alkaloid Nortopsentin as Inhibitors of Bacterial Biofilm Formation
2020
Anti-virulence strategy is currently considered a promising approach to overcome the global threat of the antibiotic resistance. Among different bacterial virulence factors, the biofilm formation is recognized as one of the most relevant. Considering the high and growing percentage of multi-drug resistant infections that are biofilm-mediated, new therapeutic agents capable of counteracting the formation of biofilms are urgently required. In this scenario, a new series of 18 thiazole derivatives was efficiently synthesized and evaluated for its ability to inhibit biofilm formation against the Gram-positive bacterial reference strains Staphylococcus aureus ATCC 25923 and S. aureus ATCC 6538 a…
Carboxylate catalyzed isomerization of β,γ‐unsaturated N-acetylcysteamine thioesters
2022
We demonstrate herein the capacity of simple carboxylate salts – tetrametylammonium and tetramethylguanidinium pivalate – to act as catalysts in the isomerization of β,γ-unsaturated thioesters to α,β-unsaturated thioesters. The carboxylate catalysts gave reaction rates comparable to those obtained with DBU, but with fewer side reactions. The reaction exhibits a normal secondary kinetic isotope effect ( k 1H / k 1D = 1.065±0.026) with a β,γ−deuterated substrate. Computational analysis of the mechanism provides a similar value ( k 1H / k 1D = 1.05) with a mechanism where γ-reprotonation of the enolate intermediate is rate determining. peerReviewed
Miksi julkaista ulkomailla?
2014
Improving statistical classification methods and ecological status assessment for river macroinvertebrates
2016
Aquatic ecosystems are facing a growing number of human-induced stressors and the need to implement more biomonitoring to assess the ecological status of water bodies is eminent. This dissertation aims at providing tools to reduce the costs and improve the accuracy of freshwater benthic macroinvertebrate biomonitoring. To improve the cost-e ciency, we consider automated classi cation and develop a novel classi er suitable for complex macroinvertebrate image data. To enhance the accuracy of macroinvertebrate biomonitoring, we study the statistical properties of the Percent Model A nity index crucial to current Finnish biomonitoring and the factors a ecting these statistics. Finally, we perfo…
Unlocking mixed oxides with unprecedented stoichiometries from heterometallic metalorganic frameworks for the catalytic hydrogenation of CO 2
2021
[EN] Their complex surface chemistry and high oxygen lattice mobilities place mixed-metal oxides among the most important families of materials. Modulation of stoichiometry in mixed-metal oxides has been shown to be a very powerful tool for tuning optical and catalytic properties. However, accessing different stoichiometries is not always synthetically possible. Here, we show that the thermal decomposition of the recently reported metal-organic framework MUV-101(Fe, Ti) results in the formation of carbon-supported titanomaghemite nanoparticles with an unprecedented Fe/Ti ratio close to 2, not achievable by soft-chemistry routes. The resulting titanomaghemite phase displays outstanding catal…
Calcium mediated polyelectrolyte adsorption on like-charged surfaces.
2011
International audience; Monte Carlo simulations within the primitive model of calcium-mediated adsorption of linear and comb polyelectrolytes onto like-charged surfaces are described, focusing on the effect of calcium and polyion concentrations as well as on the ion pairing between polymers and calcium ions. We use a combination of Monte Carlo simulations and experimental data from titration and calcium binding to quantify the ion pairing. The polymer adsorption is shown to occur as a result of surface overcharging by Ca2+ and ion pairing between charged monomers and Ca2+. In agreement with experimental observations, the simulations predict that the polymer adsorption isotherm goes through …
Implementation of Computer Assisted Experimental Work in Analytical Chemistry Laboratory Teaching
2019
[EN] Computer-Assisted Experimental Work (CAEW) consists in the incorporation of computer-connected apparatus in the laboratory. This is a new insight into teaching of Classical Analytical Chemistry, wherein the experiments are usually manually conducted. However, it does not represent a complete break with traditional methodology, as the design and goal of the experiment are essentially the same. In this work, we present the implementation of CAEW to a practical included in the Laboratory part of “Analytical Chemistry IV”, taught at the fourth academic year of the Degree in Chemistry: “Potentiometric titration of a mixture of iodure and chlorure with silver”. Three couples of students used…
Biometristen todennusmenetelmien tietoturva ja käytettävyys – sormenjälki ja silmän iiris biometrisinä tunnisteina
2016
Ihmiset joutuvat päivittäin todentamaan identiteettinsä erilaisin keinon saadakseen pääsyn esimerkiksi johonkin palveluun tai laitteeseen. Perinteisten, esimerkiksi käyttäjänimeen ja salasanaan tai ulkoisesti generoitavaan koodiin perustuvien todennusmenetelmien lisäksi erilaiset käyttäjän luonnollisiin piirteisiin perustuvat biometriset todennusmenetelmät ovat kasvattaneet suosiotaan viime vuosina. Biometriaa hyödynnetään esimerkiksi korkean turvatason kulunvalvonnassa, valtioiden rajavalvonnassa ja yksityishenkilöiden matkapuhelimissa. Tietoturvan ja käytettävyyden näkökulmat ovat tärkeitä, jotta voidaan luoda biometrisia todennusjärjestelmiä, joissa saavutetaan tyydyttävä turvataso ja sä…