Search results for "ion channel"

Yeast cultures with UCP1 uncoupling activity as a heating device

2009

7 páginas, 5 figuras, 3 tablas -- PAGS nros. 300-306

High‐Speed Channel Simulators

2011

Conceptual design of the TRACE detector readout using a compact, dead time-less analog memory ASIC

2015

[EN] The new TRacking Array for light Charged particle Ejectiles (TRACE) detector system requires monitorization and sampling of all pulses in a large number of channels with very strict space and power consumption restrictions for the front-end electronics and cabling. Its readout system is to be based on analog memory ASICs with 64 channels each that sample a View the MathML source window of the waveform of any valid pulses at 200 MHz while discarding any other signals and are read out at 50 MHz with external ADC digitization. For this purpose, a new, compact analog memory architecture is described that allows pulse capture with zero dead time in any channel while vastly reducing the tota…

Scaling properties of topologically random channel networks

1996

Abstract The analysis deals with the scaling properties of infinite topologically random channel networks (ITRNs) fast introduced by Shreve (1967, J. Geol. , 75: 179–186) to model the branching structure of rivers as a random process. The expected configuration of ITRNs displays scaling behaviour only asymptotically, when the ruler (or ‘yardstick’) length is reduced to a very small extent. The random model can also reproduce scaling behaviour at larger ruler lengths if network magnitude and diameter are functionally related according to a reported deterministic rule. This indicates that subsets of rrRNs can be scaling and, although rrRNs are asymptotically plane-filling due to the law of la…

Activation of TRPC6 calcium channels by diacylglycerol (DAG)-containing arachidonic acid: A comparative study with DAG-containing docosahexaenoic acid

2006

We synthesized a diacylglycerol (DAG)-containing arachidonic acid, i.e., 1-stearoyl-2-arachidonyl-sn-glycerol (SAG), and studied its implication in the modulation of canonical transient receptor potential sub-type 6 (TRPC6) channels in stably-transfected HEK-293 cells. SAG induced the influx of Ca(2+), and also of other bivalent cations like Ba(2+) and Sr(2+), in these cells. SAG-evoked Ca(2+) influx was not due to its metabolites as inhibitors of DAG-lipase (RHC80267) and DAG-kinase (R50922) failed to inhibit the response of the same. To emphasise that SAG exerts its action via its DAG configuration, but not due to the presence of stearic acid at sn-1 position, we synthesized 1-palmitoyl-2…

Pore entrance effects on the electrical potential distribution in charged porous membranes and ion channels

2007

Abstract Models for the electrical potential distribution in the interfacial region between a fixed charge membrane and an electrolyte solution have traditionally employed the Donnan equilibrium formalism that assumes discontinuous changes in concentrations and electric potential. In the case of the charged capillary membrane model, we propose to check rigorously the validity of this approach by solving the linearized Poisson–Boltzmann equation for the diffuse electrical double layer at the membrane|solution interface. The comparison of the resulting axial distribution for the electric potential with the Donnan potential drop shows that the discontinuous approach is only valid for membrane …

DNA-binding activities of compounds acting as enzyme inhibitors, ion channel blockers and receptor binders.

2021

The DNA-binding activities of compounds used as remedies can display DNA-protection, but also damaging effects in biological systems. The current review compiles literature data on DNA-binding activities of drugs widely used as remedies with different therapeutic indications. The compounds are classified according their mechanism of action: enzyme inhibitors, ion channel inhibitors, inhibitors of viral RNA replication and HIV protease and receptor agonists. DNA binding was reported for such widely used drugs as paracetamol, aspirin, metformin, statins and many others. The capability of the drug to bind DNA is sometimes coupled to genotoxic effects, but in some cases - to genome protection. …

The euro area sovereign debt crisis: Can contagion spread from the periphery to the core?

2014

Abstract We examine the determinants of joint default risk of euro area countries during 2007–2011. To accomplish this, we recover joint default probabilities from individual CDS contracts. In contrast to earlier theoretical studies, we find that financial linkages are an active contagion transmission channel only in the case of the troubled periphery euro area economies. During the current sovereign debt crisis, real economy linkages play a more important role in transmitting shocks from the euro area periphery towards its core. Countries that have stronger trade interconnections with troubled economies tend to have a higher expected joint default risk.

The effects of monetary policy on income and wealth inequality in the U.S. Exploring different channels

2020

We assess the effects of monetary policy shocks on income and wealth inequality through direct inequality measures and by analyzing several transmission channels explored in recent literature. Furthermore, we analyze two additional channels: the Housing and the Fiscal channels. The methodology adopted is a Bayesian proxy SVAR using a high-frequency identification based on the external instruments approach. Our own policy shocks are constructed for this purpose. The results show that an expansionary monetary policy shock does not have a significant effect on income inequality due to the existence of opposite channels, whereas it increases wealth inequality mainly through the portfolio channe…

Finance, globalisation, technology and inequality: Do nonlinearities matter?

2021

Abstract Relying on data for 90 economies over 1970-2015 and panel estimation techniques, we investigate how financial development, globalisation and technology affect income inequality. Our findings reveal significant nonlinearities, consistent with either Ushaped or inverted-U shaped relationships. As such, depending on whether a certain threshold value is achieved, the same determinants of income distribution exert opposite effects in different countries. Globalisation is associated with increasing inequality in most advanced economies, but with falling disparities for the large majority of emerging economies. Technology and financial development lead to increasing inequality for most em…