Search results for "ion channel"

Arginine-rich peptides are blockers of VR-1 channels with analgesic activity

2000

Vanilloid receptors (VRs) play a fundamental role in the transduction of peripheral tissue injury and/or inflammation responses. Molecules that antagonize VR channel activity may act as selective and potent analgesics. We report that synthetic arginine-rich hexapeptides block heterologously expressed VR-1 channels with submicromolar efficacy in a weak voltage-dependent manner, consistent with a binding site located near/at the entryway of the aqueous pore. Dynorphins, natural arginine-rich peptides, also blocked VR-1 activity with micromolar affinity. Notably, synthetic and natural arginine-rich peptides attenuated the ocular irritation produced by topical capsaicin application onto the eye…

Distal Arthrogryposis type 5 in an Italian family due to an autosomal dominant gain-of-function mutation of the PIEZO2 gene

2022

Abstract Background Arthrogryposis multiplex congenita (AMC) is a group of clinically and etiologically heterogeneous conditions, characterized by prenatal onset contractures affecting two or more joints. Its incidence is about 1 in 3000 live births. AMC may be distinguished into amyoplasia, distal and syndromic arthrogryposis. Distal arthrogryposis (DA) predominantly affects hands and feet. It is currently divided into more than ten subtypes (DA1, DA2A/B, DA3–10), based on clinical manifestations, gene mutations and inheritance pattern. Among them, only a few patients with DA5 have been reported. It is associated to a gain-of-function pathogenic variant of the PIEZO2 gene, encoding for an …

Modelling and Analysis of Nonstationary Vehicle-to-Infrastructure Channels with Time-Variant Angles of Arrival

2018

In mobile radio channel modelling, it is generally assumed that the angles of arrival (AOAs) are independent of time. This assumption does not in general agree with real-world channels in which the AOAs vary with the position of a moving receiver. In this paper, we first present a mathematical model for the time-variant AOAs. This model serves as the basis for the development of two nonstationary multipath fading channels models for vehicle-to-infrastructure communications. The statistical properties of both channel models are analysed with emphasis on the time-dependent autocorrelation function (ACF), time-dependent mean Doppler shift, time-dependent Doppler spread, and the Wigner-Ville sp…

Statistical modeling, simulation, and experimental verification of wideband indoor mobile radio channel

2018

This paper focuses on the modeling, simulation, and experimental verification of wideband single-input single-output (SISO) mobile fading channels for indoor propagation environments. The indoor reference channel model is derived from a geometrical rectangle scattering model, which consists of an infinite number of scatterers. It is assumed that the scatterers are exponentially distributed over the two-dimensional (2D) horizontal plane of a rectangular room. Analytical expressions are derived for the probability density function (PDF) of the angle of arrival (AOA), the PDF of the propagation path length, the power delay profile (PDP), and the frequency correlation function (FCF). An efficie…

Correction to “A generalized single-channel method for retrieving land surface temperature from remote sensing data” by Juan C. Jiménez-Muñoz and Jos…

2004

A generalized single‐channel method for retrieving land surface temperature from remote sensing data

2003

[1] Many papers have developed algorithms to retrieve land surface temperature from at-sensor and land surface emissivity data. These algorithms have been specified for different thermal sensors on board satellites, i.e., the algorithm used for one thermal sensor (or a combination of thermal sensors) cannot be used for other thermal sensor. The main goal of this paper is to propose a generalized single-channel algorithm that only uses the total atmospheric water vapour content and the channel effective wavelength (assuming that emissivity is known), and can be applied to thermal sensors characterized with a FWHM (Full-Width Half-Maximum) of around 1 μm actually operative on board satellites…

Operational considerations to improve total ozone measurements with a Microtops II ozone monitor

2012

A Microtops II "ozone monitor" with UV channels centered at 305.5, 312.5, and 320 nm has been used routinely in six experimental campaigns carried out in several geographic locations and seasons, covering latitudes from 35 to 68° N during the last ten years (2001–2011). The total ozone content is retrieved by Microtops II by using different combinations (Channel I, 305.5/312.5 nm; Channel II, 312.5/320 nm; and Channel III, 305.5/312.5/320 nm) of the signals at the three ultraviolet wavelengths. The long-term performance of the total ozone content determination has been studied taking into account the sensitivities to the calibration, airmass, temperature and aerosols. When a calibration was…

Doppler Estimation and Correction for JANUS Underwater Communications

2020

In recent years, underwater communications have seen a growing interest pushed by marine research, oceanography, marine commercial operations, offshore oil industry and defense applications. Generally, underwater communications employ audio signals which can propagate relatively far but are also significantly affected by Doppler distortions. In fact, physical properties of the water and spatial changes due to tides, currents and waves can cause channel variations or unwanted movements of the transmitter or receiver. This study shows how to compensate for the Doppler effect in transmission employing the JANUS standard, a popular modulation scheme for underwater communication. Differently for…

A Two-Dimensional Autoregressive Model for MIMO Wideband Mobile Radio Channels

2008

In this work, we propose the multichannel two- dimensional (2D) autoregressive (AR) model for multiple-input multiple-output (MIMO) wideband mobile wireless channels. The parameters of the proposed model can be estimated from the real- world measurement data. For this purpose, we suggest using a straightforward extension of the prediction error minimization (PEM) algorithm. We also address the problem of possible instability of the multichannel 2D AR model. A model stabilization procedure based on numerical optimization techniques is proposed. The performance of the multichannel 2D AR model has been evaluated based on the synthetic data generated using two different channel simulators.

Level-crossing rate and average duration of fades of non-stationary multipath fading channels

2017

The level-crossing rate (LCR) and average duration of fades (ADF) are important statistical quantities describing the fading behaviour of mobile radio channels. To date, these quantities have only been analysed under the assumption that the mobile radio channel is wide-sense stationary, which is generally not the case in practice. In this paper, we propose a concept for the analysis of the LCR and ADF of non-stationary channels. Rice's standard formula for the derivation of the LCR of wide-sense stationary processes is extended to a more general formula enabling the computation of the instantaneous LCR of non-stationary processes. The application of the new concept results in closed-form ex…