Search results for "iran"

showing 10 items of 347 documents

New Frontiers in the Treatment of Homozygous Familial Hypercholesterolemia.

2021

: Homozygous familial hypercholesterolemia (HoFH) is a rare genetic disorder. The most common cause is a mutation in both alleles of the gene encoding for the low-density lipoprotein (LDL) receptor, although other causative mutations have been identified. Complications of atherosclerotic cardiovascular disease are common in these patients; therefore, reducing the elevated LDL-cholesterol burden is critical in their management. Conventionally, this is achieved by patients initiating lipid-lowering therapy, but this can present challenges in clinical practice. Fortunately, novel therapeutic strategies have enabled promising innovations in HoFH treatment. This review highlights recent and ongo…

Settore MED/09 - Medicina InternaGenetic enhancementHomozygous familial hypercholesterolemiaFamilial hypercholesterolemiaInclisiranBioinformaticsmedicine.disease_causeBenzimidazolePCSK9Hyperlipoproteinemia Type IIchemistry.chemical_compoundGene therapyAnticholesteremic AgentmedicineAngiopoietin-like 3HumansLow-density lipoprotein cholesterolAlleleAngiopoietin-like 3; Gene therapy; Gene-editing; Homozygous familial hypercholesterolemia; Inclisiran; Lomitapide; Low-density lipoprotein cholesterol; PCSK9MutationGene-editingAtherosclerotic cardiovascular diseasebusiness.industryPCSK9Anticholesteremic AgentsHomozygoteGenetic disorderGeneral MedicineCholesterol LDLmedicine.diseaseLomitapideLomitapidechemistrylipids (amino acids peptides and proteins)BenzimidazolesCardiology and Cardiovascular MedicinebusinessHumanHeart failure clinics
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Genetic relatedness among isolates of Shigella sonnei carrying class 2 integrons in Tehran, Iran, 2002–2003

2007

Abstract Background Shigella spp. are major cause of diarrhoeal disease in both developing and developed countries. Shigella sonnei is the serogroup of Shigella most frequently responsible for sporadic and epidemic enteritis in developed countries. In recent years the emergence and spread of S. sonnei biotype g carrying class 2 integron have been frequently reported in many countries. Recently, S. sonnei has been reported as the prevalent serogroup of Shigella in Iran. The present study was carried out to investigate phenotypic and genetic characteristics of Shigella sonnei isolates identified in the years 2002 and 2003 in Tehran, Iran. Methods Biotyping, drug susceptibility testing, pulsed…

Shigellosismedicine.medical_specialtySettore MED/07 - Microbiologia E Microbiologia ClinicaEndemic DiseasesGenotypeShigella sonneiBiologyIranmedicine.disease_causeIntegronSettore MED/42 - Igiene Generale E ApplicataEnteritisMicrobiologyIntegronslcsh:Infectious and parasitic diseasesMedical microbiologyGenotypeDrug Resistance BacterialmedicinePrevalenceHumansShigella sonneiShigellalcsh:RC109-216Shigella enteritis IranDysentery Bacillarybiochemical phenomena metabolism and nutritionmedicine.diseasebacterial infections and mycosesPhenotypeInfectious DiseasesParasitologybiology.proteinbacteriaResearch ArticleBMC Infectious Diseases
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El totus orbis y el ius gentium en Francisco de Vitoria: el equilibrio entre tradición e innovación

2017

Resumen: El artículo examina dos conceptos centrales en la doctrina internacional de Vitoria: la idea de orbe como comunidad universal de todos los hombres y de todos los pueblos unidos por el vínculo de la común naturaleza humana, y el ius gentium como Derecho universal de la humanidad que rige en todo el orbe. El trabajo destaca el equilibrio entre tradición (universalismo cosmopolita de raíces estoicas y cristianas y iusnaturalismo clásico) e innovación (ideas de derechos naturales, de igualdad e independencia de todos los pueblos y concepción de la comunidad internacional como una comunidad jurídica) y la antropología no individualista que subyace a la doctrina internacional de Vitoria.…

SobiraniaDret naturalDrets humans
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La sobirania feminista en l'època del neoliberalisme

2019

El feminisme sempre ha estat un moviment rupturista i revolucionari i s’ha convertit els darrers anys, a l’àmbit local i mundial, en un important mur de contenció de les polítiques regressives, autoritàries i destructores, impulsades pel neoliberalisme i les seues derivades xenòfobes, racistes, teocràtiques i patriarcals. Alhora ha sigut i és un poderós moviment d’apoderament de les dones i amb elles els sectors socials més avançats. I ho ha fet basant-se més en valors que en estructures organitzatives.

SobiraniaUNESCO::SOCIOLOGÍApatriarcatextrema dreta:SOCIOLOGÍA [UNESCO]feminisme
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First data on the taxonomic diversity of the Portulaca oleracea aggregate (Portulacaceae) in Iran

2017

The review of specimens from Iran belonging to the Portulaca oleracea L. aggregate resulted in the recognition of six microspecies: P. cypria Danin, P. granulatostellulata (Poelln.) Ricceri & Arrigoni, P. nitida (Danin & H.G.Baker) Ricceri & Arrigoni, P. rausii Danin, P. socotrana Domina & Raimondo, and P. trituberculata Danin, Domina & Raimondo, all reported for the first time for the flora of Iran. The identification was based on the microscopic study of seeds. It is noted that P. oleracea is not confirmed for Iran. Distribution data and an identification key for Portulaca microspecies in Iran are presented.

SocotranaMiddle eastSettore BIO/02 - Botanica SistematicaIdentification keyPlant ScienceBiologyPortulacaIranbiology.organism_classificationPurslaneFloristic investigationIranmicromorphologypurslaneMiddle EastBotanySettore BIO/03 - Botanica Ambientale E ApplicataMicromorphologyPortulacaceaeFloristic investigation
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CCDC 1543288: Experimental Crystal Structure Determination

2017

Related Article: J. Vigier, C. François, S. Pourchet, G. Boni, L. Plasseraud, V. Placet, S. Fontaine, H. Cattey|2017|Acta Crystallogr.,Sect.E:Cryst.Commun.|73|694|doi:10.1107/S2056989017005370

Space GroupCrystallography2-({3-methoxy-4-[(oxiran-2-yl)methoxy]phenyl}methyl)oxiraneCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1427361: Experimental Crystal Structure Determination

2015

Related Article: Felicitas Lips, James C. Fettinger, Akseli Mansikkamäki, Heikki M. Tuononen, and Philip P. Power|2014|J.Am.Chem.Soc.|136|634|doi:10.1021/ja411951y

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters11-bis((22''66''-tetraisopropyl-11':3'1''-terphenyl-2'-yl)sulfanyl)silirane toluene solvateExperimental 3D Coordinates
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CCDC 977799: Experimental Crystal Structure Determination

2015

Related Article: Ming W. Shi, Alexandre N. Sobolev, Tanja Schirmeister, Bernd Engels, Thomas C. Schmidt, Peter Luger, Stefan Mebs, Birger Dittrich, Yu-Sheng Chen, Joanna M. Bąk, Dylan Jayatilaka, Charles S. Bond, Michael J. Turner, Scott G. Stewart, Mark A. Spackman and Simon Grabowsky|2015|New J.Chem.|39|1628|doi:10.1039/C4NJ01503G

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters3-((4-methyl-1-((3-methylbutyl)amino)-1-oxopentan-2-yl)carbamoyl)oxirane-2-carboxylic acidExperimental 3D Coordinates
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CCDC 892598: Experimental Crystal Structure Determination

2013

Related Article: C.Lohoelter, D.Schollmeyer, S.R.Waldvogel|2012|Eur.J.Org.Chem.|2012|6364|doi:10.1002/ejoc.201200970

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersMethyl 5'9'13'-trimethyldispiro[oxirane-214'-tetracyclo[11.2.1.0^110^.0^49^]hexadecane-15'2''-oxirane]-5'-carboxylateExperimental 3D Coordinates
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CCDC 1498219: Experimental Crystal Structure Determination

2017

Related Article: Ming W. Shi, Scott G. Stewart, Alexandre N. Sobolev, Birger Dittrich, Tanja Schirmeister, Peter Luger, Malte Hesse, Yu-Sheng Chen, Peter R. Spackman,Mark A. Spackman, Simon Grabowsky|2017|J.Phys.Org.Chem.|30|e3683|doi:10.1002/poc.3683

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parametersethyl (2R3R)-3-((S)-1-((benzyloxy)carbonyl)phenylalanyl)oxirane-2-carboxylateExperimental 3D Coordinates
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