Search results for "isoxazole"

showing 10 items of 100 documents

CCDC 963005: Experimental Crystal Structure Determination

2013

Related Article: Roberta Ettari, Lucia Tamborini, Ilenia C. Angelo, Silvana Grasso, Tanja Schirmeister, Leonardo Lo Presti, Carlo De Micheli, Andrea Pinto, Paola Conti|2013|ChemMedChem|8|2070|doi:10.1002/cmdc.201300390

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(3aS6aS)-t-Butyl-3-bromo-66a-dihydro-3aH-pyrrolo[34-d]isoxazole-5(4H)-carboxylateExperimental 3D Coordinates
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CCDC 999257: Experimental Crystal Structure Determination

2014

Related Article: Kirsi Salorinne, Tanja Lahtinen, Varpu Marjomäki, Hannu Häkkinen|2014|CrystEngComm|16|9001|doi:10.1039/C4CE01152J

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters5-(3-(26-Dimethyl-4-(5-methyl-124-oxadiazol-3-yl)phenoxy)propyl)isoxazole-3-carboxylic acid dimethyl sulfoxide solvateExperimental 3D Coordinates
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CCDC 999256: Experimental Crystal Structure Determination

2014

Related Article: Kirsi Salorinne, Tanja Lahtinen, Varpu Marjomäki, Hannu Häkkinen|2014|CrystEngComm|16|9001|doi:10.1039/C4CE01152J

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters5-(3-(26-Dimethyl-4-(5-methyl-124-oxadiazol-3-yl)phenoxy)propyl)isoxazole-3-carboxylic acid ethanol solvateExperimental 3D Coordinates
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CCDC 148163: Experimental Crystal Structure Determination

2001

Related Article: M.Carda, R.Portoles, J.Murga, S.Uriel, J.A.Marco, L.R.Domingo, R.J.Zaragoza, H.Roper|2000|J.Org.Chem.|65|7000|doi:10.1021/jo0009651

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersDimethyl (3aS)-3a-((4R)-22-dimethyl-13-dioxolan-4-yl)-66-dimethyl-3a4-dihydro(13)oxazolo(34-b)isoxazole-23-dicarboxylateExperimental 3D Coordinates
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CCDC 148164: Experimental Crystal Structure Determination

2001

Related Article: M.Carda, R.Portoles, J.Murga, S.Uriel, J.A.Marco, L.R.Domingo, R.J.Zaragoza, H.Roper|2000|J.Org.Chem.|65|7000|doi:10.1021/jo0009651

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersEthyl (3aS)-3a-((4R)-22-dimethyl-13-dioxolan-4-yl)-66-dimethyl-3a4-dihydro(13)oxazolo(34-b)isoxazole-3-carboxylateExperimental 3D Coordinates
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CCDC 999254: Experimental Crystal Structure Determination

2014

Related Article: Kirsi Salorinne, Tanja Lahtinen, Varpu Marjomäki, Hannu Häkkinen|2014|CrystEngComm|16|9001|doi:10.1039/C4CE01152J

Space GroupCrystallographyCrystal SystemCrystal StructureEthyl 5-(3-(26-dimethyl-4-(5-methyl-124-oxadiazol-3-yl)phenoxy)propyl)isoxazole-3-carboxylateCell ParametersExperimental 3D Coordinates
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CCDC 999255: Experimental Crystal Structure Determination

2014

Related Article: Kirsi Salorinne, Tanja Lahtinen, Varpu Marjomäki, Hannu Häkkinen|2014|CrystEngComm|16|9001|doi:10.1039/C4CE01152J

Space GroupCrystallographyCrystal SystemCrystal StructureEthyl 5-(3-(26-dimethyl-4-(5-methyl-124-oxadiazol-3-yl)phenoxy)propyl)isoxazole-3-carboxylateCell ParametersExperimental 3D Coordinates
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Mononuclear heterocyclic rearrangements—vi

1974

Publisher Summary This chapter discusses the mononuclear heterocyclic rearrangements. The chapter discusses the ring conversion of type 1→2 characterized by nucleophilic attack from a Z atom on a sp 2 -nitrogen atom with displacement of an atom. On this basis, the known ring conversions are tabulated. Taking into account the reactivities observed in the rearrangements, results are presented for 1,2,4-oxadiazole, isoxazole, and 1,2,5-oxadiazole. The sequence involving an oxime group in the side chain is discussed. The chapter presents several attempts for inducing rearrangements in which the reaction center of the starting ring is an atom other than nitrogen. Rearrangement of arylhydrazones …

StereochemistryOrganic ChemistryAtom (order theory)OximeRing (chemistry)Biochemistrychemistry.chemical_compoundchemistryNucleophileDrug DiscoverySide chainIsoxazoleBenzeneIsomerizationTetrahedron
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Heterocycle-containing retinoids. Discovery of a novel isoxazole arotinoid possessing potent apoptotic activity in multidrug and drug-induced apoptos…

2001

In a search for retinoic acid (RA) receptor ligands endowed with potent apoptotic activity, a series of novel arotinoids were prepared. Because the stereochemistry of the C9-alkenyl portion of natural 9-cis-RA and the olefinic moiety of the previously synthesized isoxazole retinoid 4 seems to have particular importance for their apoptotic activity, novel retinoid analogues with a restricted or, vice versa, a larger flexibility in this region were designed and prepared. The new compounds were evaluated in vitro for their ability to activate natural retinoid receptors and for their differentiation-inducing activity. Cytotoxic and apoptotic activities were, in addition, evaluated. In general, …

Transcriptional ActivationProgrammed cell deathTetrahydronaphthalenesmedicine.drug_classReceptors Retinoic AcidRetinoic acidAntineoplastic AgentsApoptosisBenzoateschemistry.chemical_compoundInhibitory Concentration 50RetinoidsDrug DiscoverymedicineTumor Cells CulturedHumansRetinoidIsoxazoleCytotoxicityReceptorCell DifferentiationIsoxazolesIn vitroDrug Resistance MultipleBiochemistrychemistryApoptosisDrug Resistance NeoplasmMolecular MedicineDrug Screening Assays AntitumorCell DivisionJournal of medicinal chemistry
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Leaching of glyphosate and AMPA under two soil management practices in Burgundy vineyards (Vosne-Romanée, 21-France)

2005

Some drinking water reservoirs under the vineyards of Burgundy are contaminated with herbicides. Thus the effectiveness of alternative soil management practices, such as grass cover, for reducing the leaching of glyphosate and its metabolite, AMPA, through soils was studied. The leaching of both molecules was studied in structured soil columns under outdoor conditions for 1 year. The soil was managed under two vineyard soil practices: a chemically treated bare calcosol, and a vegetated calcosol. After 680 mm of rainfall, the vegetated calcosol leachates contained lower amounts of glyphosate and AMPA (0.02% and 0.03%, respectively) than the bare calcosol leachates (0.06% and 0.15%, respectiv…

[SDE] Environmental SciencesHealth Toxicology and Mutagenesis010501 environmental sciencesToxicology01 natural sciences[ SDE ] Environmental SciencesSoil managementchemistry.chemical_compoundSoilAMPASoil PollutantsVitisLeaching (agriculture)Water pollutionComputingMilieux_MISCELLANEOUS2. Zero hungerAgriculture04 agricultural and veterinary sciencesGeneral MedicinePollutionSoil contaminationSTRUCTURED SOIL COLUMN6. Clean waterGlyphosate[SDE]Environmental SciencesFrancePorosityEnvironmental MonitoringGRASS COVERGlycineGLYPHOSATEPoaceaecomplex mixturesWater MovementsHumansalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid0105 earth and related environmental sciencesCambisolHerbicides15. Life on land[SDE.ES]Environmental Sciences/Environmental and SocietyTRANSPORTAgronomychemistrySoil water040103 agronomy & agriculture0401 agriculture forestry and fisheriesEnvironmental scienceGroundwaterWater Pollutants Chemical
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