Search results for "joining"

showing 10 items of 37 documents

Review on mechanical joining by plastic deformation

2022

Mechanical joining technologies are increasingly used in multi-material lightweight constructions and offer opportunities to create versatile joining processes due to their low heat input, robustness to metallurgical incompatibilities and various process variants. They can be categorised into technologies which require an auxiliary joining element, or do not require an auxiliary joining element. A typical example for a mechanical joining process with auxiliary joining element is self-piercing riveting. A wide range of processes exist which are not requiring an auxiliary joining element. This allows both point-shaped (e.g., by clinching) and line-shaped (e.g., friction stir welding) joints t…

Mechanical joiningVersatilityClinchingPin-joiningMechanics of MaterialsMechanical EngineeringSelf-piercing rivetingChemical Engineering (miscellaneous)Joining processesEngineering (miscellaneous)Journal of Advanced Joining Processes
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Phylogeography and demographic inference in Nacella (Patinigera) concinna (Strebel, 1908) in the western Antarctic Peninsula

2011

10 pages; International audience; Endemic to Antarctic ecosystems, the limpet Nacella (Patinigera) concinna (Strebel, 1908) is an abundant and dominant marine benthic invertebrate of the intertidal and shallow subtidal zone. In order to examine the phylogeographic pattern and historical demography of the species along the western Antarctic Peninsula, we amplified 663 bp of the mitochondrial DNA cytochrome oxidase subunit I of 161 N. concinna specimens from five localities, as well as two specimens from South Georgia and Sub-Antarctic Marion Island. As two different morphotypes, one characterized by an elevated shell in the intertidal and the other by a flat one in the subtidal, have been re…

Median-joining network0106 biological sciencesNacellaRange (biology)PopulationIntertidal zoneBiology[SDV.BID.SPT]Life Sciences [q-bio]/Biodiversity/Systematics Phylogenetics and taxonomyOceanography010603 evolutionary biology01 natural sciencesCOI14. Life underwaterSouthern OceaneducationBottleneck effectGenetic diversityeducation.field_of_study[SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE]Nacella concinnaEcology010604 marine biology & hydrobiologyLimpetElliptic FourieranalysisFounder effectbiology.organism_classification[SDV.BA.ZI]Life Sciences [q-bio]/Animal biology/Invertebrate Zoology[ SDV.GEN.GPO ] Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE]PhylogeographyOceanographyGenetic structureAntarcticaGenetic structure[ SDV.BID.SPT ] Life Sciences [q-bio]/Biodiversity/Systematics Phylogenetics and taxonomyDeep Sea Research Part II: Topical Studies in Oceanography
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Molecular fingerprinting evidence (ISSR, Inter-Simple Sequence Repeats) for a wild status of Olea europaea L. (Oleaceae) in the Eurosiberian North of…

2001

Summary Although the olive tree ( Olea europaea L.) is one of the best indicators of the Mediterranean region, there exist some isolated populations of this species in the Eurosiberian North of the Iberian Peninsula. To elucidate the wild or feral status of these populations, we studied a total of 46 populations of the Olea europaea complex. mat K sequences and Inter-Simple Sequence Repeats (ISSR) variation were analysed to infer relationships among the six subspecies of the Olea europaea complex and within O. europaea subsp. europaea. Based on mat K. sequences, populations of sspp. europaea (Mediterranean basin), cerasiformis (Madeira), guanchica (Canary Islands), maroccana (Agadir Mountai…

Mediterranean climateEcologybiologyBiogeographyUPGMAPlant ScienceSubspeciesbiology.organism_classificationMediterranean BasinOleaOleaceaeBotanyNeighbor joiningEcology Evolution Behavior and SystematicsFlora
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TOWARD A DESIGN METHOD FOR METAL-COMPOSITE CO-CURED JOINT BASED ON THE G-SIFs

2013

Abstract In this work, a systematic study of the singular stress field in the zone where the interface intersects the free edge surfaces of bonded metal-composite co-cured joints, has been performed. The obtained theoretical, numerical and experimental results have permitted to detect the relationships between the joint configuration and the singular stress field, as well as to implement a new design method based on the so called generalised stress intensity factors. Such a proposed method allows the user to predict the static strength of a generic metal-composite co-cured joint, vs. the main influence parameters as the elastic modulus of the coupled materials, the overlap length, the taper…

Polymer-matrix composites (PMCs)Work (thermodynamics)Materials sciencebusiness.industryMechanical EngineeringComposite numberStructural engineeringIndustrial and Manufacturing EngineeringJoints/joiningStress fieldAnalytical modelingSettore ING-IND/14 - Progettazione Meccanica E Costruzione Di MacchineLap jointMechanics of MaterialsCeramics and CompositesStrengthComposite materialbusinessElastic modulusJoint (geology)Stress intensity factorReliability (statistics)
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Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes.

2020

Background: Naturally occurring variation in Membrane-bound O-acyltransferase domain-containing 7 (MBOAT7), encoding for an enzyme involved in phosphatidylinositol acyl-chain remodelling, has been associated with fatty liver and hepatic disorders. Here, we examined the relationship between hepatic Mboat7 down-regulation and fat accumulation. Methods: Hepatic MBOAT7 expression was surveyed in 119 obese individuals and in experimental models. MBOAT7 was acutely silenced by antisense oligonucleotides in C57Bl/6 mice, and by CRISPR/Cas9 in HepG2 hepatocytes. Findings: In obese individuals, hepatic MBOAT7 mRNA decreased from normal liver to steatohepatitis, independently of diabetes, inflammatio…

Research paperTGFβ Transforming Growth Factor BetaIntracellular SpaceCRISPR Clustered Regularly Interspaced Short Palindromic RepeatshHEPS Human HepatocytesMice0302 clinical medicineLPIAT1DAG Diacylglyceroli.p. Intraperitonealmedia_commonFatty AcidsGeneral Medicine3. Good health030220 oncology & carcinogenesisHOMA-IR homeostasis Model Assessment of Insulin ResistanceMPO morpholinolcsh:Medicine (General)medicine.medical_specialtyPE Phosphatidyl-EthanolamineNashGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciencesTNFα tumor Necrosis Factor AlphaLDL Low Density LipoproteinsHyperinsulinismNAFLDSD Standard Dietmedia_common.cataloged_instanceHumansCPT1 Carnitine Palmitoyltransferase IPhosphatidylinositolGene SilencingEuropean unionVLDL Very Low Density Lipoproteinlcsh:RhHSC Human Hepatic Stellate Cellsmedicine.diseaseLipid MetabolismOA Oleic AcidCI Confidence IntervalMboat7 Membrane bound O-acyltransferase domain containing 7MCD methionine choline deficient diet030104 developmental biologyEndocrinologychemistryCDP Cytidine-DiphosphateFOXO1 Forkhead Box protein O1NAFLD nonalcoholic fatty liver diseaseSteatohepatitisBMI Body Mass IndexCL CardiolipinAcyltransferases0301 basic medicineAlcoholic liver diseaseCXCL10 C-X-C Motif Chemokine 10lcsh:Medicinechemistry.chemical_compoundNon-alcoholic Fatty Liver DiseaseIFG Impaired Fasting GlucoseAPOB Apolipoprotein BNonalcoholic fatty liver diseasePIP Phosphatidyl-Inositol-PhosphateSteatohepatitisqRT-PCR quantitative Real Time Polymerase Chain ReactionMice Knockoutlcsh:R5-920ORO Oil Red O StainingPI PhosphatidylinositolFatty liverTM6SF2 Transmembrane 6 Superfamily Member 2PhospholipidTAG TriglyceridesNASH Nonalcoholic SteatohepatitisLipogenesisLPA Lyso-Phosphatidic AcidPhosphatidylinositolSignal TransductionPS Phosphatidyl-SerinePA Palmitic AcidALD alcoholic liver diseasePC Phosphatidylcholinei.v. IntravenousFATP1 Fatty Acid Transport Protein 1Models BiologicalInternal medicinemedicineAnimalsNonalcoholic fatty liver diseasePPARα Peroxisome Proliferator-Activated Receptor alphaObesityG3P Glyceraldehyde-3-PhosphateSREBP1c Sterol Regulatory Element-Binding Protein 1HDL High Density Lipoproteinsbusiness.industryPI3K Phosphatidylinositol 3 KinaseMembrane ProteinsNHEJ Non-Homologues End JoiningPNPLA3 Patatin-like Phospholipase Domain-containing-3MTTP Microsomal Triglyceride Transfer ProteinLPIAT1 Lysophosphatidylinositol Acyltransferase 1TMC4 Transmembrane Channel-Like 4Disease Models AnimalGene Expression RegulationHepatocytesFOXA2 Forkhead Box A2mTOR mammalian target of RapamycinSteatosisInsulin ResistancebusinessPG Phosphatidyl-GlycerolFABP1 Fatty Acid-Binding Protein 1 FAS Fatty Acid SynthaseT2DM Type 2 Diabetes MellitusEBioMedicine
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Experimental study of SPR-bonded joints CFRP-AA2024-T6

2012

Settore ING-IND/14 - Progettazione Meccanica E Costruzione Di MacchineJoining SPR hybridSettore ING-IND/16 - Tecnologie E Sistemi Di Lavorazione
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Influence of the distance between rivets in self-piercing riveting bonded joints made of carbon fiber panels and AA2024 blanks

2012

Abstract The increasing use of new materials alternative to steel in manufacturing industry has led to a greater emphasis on the improvement and the development of specific joining approaches allowing to get effective mechanical properties even when different materials are joined together. It should be observed that often the traditional welding techniques show several limitations as aluminum or magnesium alloys are used, and, what is more, they are not compatible with composite materials. The development of structures made of these materials has renewed the use of mechanical fastening operations. The present paper investigates the influence of the distance between rivets in self-piercing r…

Settore ING-IND/14 - Progettazione Meccanica E Costruzione Di MacchineMaterials scienceCarbon fiber compositelawCombined useRivetNew materialsAdhesiveWeldingComposite materialSPR bonding joiningSettore ING-IND/16 - Tecnologie E Sistemi Di Lavorazionelaw.inventionMaterials & Design
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Fatigue characterization of hybrid joints CFRP-aluminum obtained by Self-Pierce Riveting (SPR)

2012

Settore ING-IND/14 - Progettazione Meccanica E Costruzione Di MacchineSettore ING-IND/16 - Tecnologie E Sistemi Di LavorazioneSPR joining hybrid joints
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Numerical Simulation of Lightweight Alloys Alternative Joining Techniques

2008

Settore ING-IND/16 - Tecnologie E Sistemi Di LavorazioneJoining FEM
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R-Rescovitine (Seliciclib) inhibits DNA damage-induced Cyclin A1 up-regulation and hinders non-homologous end joining: a rationale for therapeutic co…

2011

Settore MED/06 - Oncologia Medicahinders non-homologous end joiningtherapeutic combinationR_Rescovitine inhibits DNA damage-induced Cyclin A1 up-regulation
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