Search results for "kakeksia"
showing 3 items of 3 documents
Activin-A, myostatin and interleukin-6 in cancer associated cachexia
2017
Cachexia is a muscle wasting condition associated with multiple different chronic illnesses, such as cancer, diabetes and AIDS. In cancer, approximately 80% of patients with advanced disease have symptoms of muscle wasting, and around 25% of cancer mortality concerns cachexia. Elevated serum levels of different cytokines and TGF-β protein family members, such as Interleukin-6, Myostatin and Activin-A, have been observed in cachetic patients and test animals. However, the mechanistic role and the relative contribution of these molecules to muscle loss in the syndrome have not yet been fully elucidated. In this thesis, the gene-expression levels of Activin-A, Myostatin and Interleukin-6 was a…
Exercise medicine for cancer cachexia: targeted exercise to counteract mechanisms and treatment side effects.
2022
Abstract Purpose Cancer-induced muscle wasting (i.e., cancer cachexia, CC) is a common and devastating syndrome that results in the death of more than 1 in 5 patients. Although primarily a result of elevated inflammation, there are multiple mechanisms that complement and amplify one another. Research on the use of exercise to manage CC is still limited, while exercise for CC management has been recently discouraged. Moreover, there is a lack of understanding that exercise is not a single medicine, but mode, type, dosage, and timing (exercise prescription) have distinct health outcomes. The purpose of this review was to examine the effects of these modes and subtypes to identify the most opt…
Kakeksian mekanismit ja hoito
2022
Kakeksia on sairauden aiheuttama tila, jossa paino sekä luurankolihaksen ja rasvakudoksen määrä vähenevät ja toimintakyky heikkenee, eikä näitä oireita voida täysin kumota ravitsemuksen tuella. Kakeksiaa esiintyy erityisesti syöpäsairauksien yhteydessä. Se heikentää elämänlaatua, lisää kuolleisuutta ja hankaloittaa perustaudin hoitovasteen saavuttamista. Kakeksian patofysiologia tunnetaan vain osittain. Tärkeimpiä mekanismeja ovat yleistynyt tulehdusvaste, luurankolihaksen surkastuminen, rasvakudoksen aineenvaihdunnan muutokset ja hormonaalisen toiminnan häiriintyminen. Yksittäisiin tekijöihin vaikuttavat lääkitykset eivät tilan monitekijäisen patofysiologian vuoksi tehoa riittävästi, eikä …