Search results for "kami"
showing 10 items of 149 documents
Cmentarz Sapieżyński w Stanisławowie
2021
This article presents the history of one of the largest Polish cemeteries in the Eastern Borderlands. Thousands of Poles, including artists, poets, writers, sculptors, prominent politicians, local government officials and soldiers fighting for Polish independence in various uprisings, were buried in the Sapieżyński Cemetery during its 200-year-long history. The necropolis was closed down by the Soviet authorities in 1980, and the entire area was bulldozed. Crushed tombstones were transported outside the city, and a theater building and a hotel were developed on the site. The paper recreates the cemetery’s history and tells the life stories of the most prominent individuals who were laid to …
Plasma membrane and lysosomal localization of CB1 cannabinoid receptor are dependent on lipid rafts and regulated by anandamide in human breast cance…
2005
AbstractIn this report we show, by confocal analysis of indirect immunofluorescence, that the type-1 cannabinoid receptor (CB1R), which belongs to the family of G-protein-coupled receptors, is expressed on the plasma membrane in human breast cancer MDA-MB-231 cells. However, a substantial proportion of the receptor is present in lysosomes. We found that CB1R is associated with cholesterol- and sphyngolipid-enriched membrane domains (rafts). Cholesterol depletion by methyl-β-cyclodextrin (MCD) treatment strongly reduces the flotation of the protein on the raft-fractions (DRM) of sucrose density gradients suggesting that CB1 raft-association is cholesterol dependent. Interestingly binding of …
Evidence for a modulatory role of cannabinoids on the excitatory NANC neurotransmission in mouse colon
2007
Abstract It is well accepted that endogenous cannabinoids and CB1 receptors are involved in the regulation of smooth muscle contractility and intestinal motility, through a mechanism mainly related to reduction of acetylcholine release from cholinergic nerve endings. Because, few data exist on a possible modulatory action of the cannabinoid agents on the non-adrenergic non-cholinergic (NANC) excitatory and inhibitory neurotransmission, the aim of the present study was to investigate the effects of cannabinoid drugs on the NANC responses elicited by electrical field stimulation (EFS) in the circular muscle of mouse proximal colon. Colonic contractions were monitored as changes in endoluminal…
Cannabinoid CB1 receptors regulate neuronal TNF-α effects in experimental autoimmune encephalomyelitis.
2011
Abstract Cannabinoid CB1 receptors (CB1Rs) regulate the neurodegenerative damage of experimental autoimmune encephalomyelitis (EAE) and of multiple sclerosis (MS). The mechanism by which CB1R stimulation exerts protective effects is still unclear. Here we show that pharmacological activation of CB1Rs dampens the tumor necrosis factor α (TNFα)-mediated potentiation of striatal spontaneous glutamate-mediated excitatory postsynaptic currents (EPSCs), which is believed to cogently contribute to the inflammation-induced neurodegenerative damage observed in EAE mice. Furthermore, mice lacking CB1Rs showed a more severe clinical course and, in parallel, exacerbated alterations of sEPSC duration af…
Anandamide-induced apoptosis in Chang liver cells involves ceramide and JNK/AP-1 pathway
2006
In the present study we demonstrate that anandamide, the most important endogenous cannabinoid, markedly induced apoptosis in Chang liver cells, an immortalized non-tumor cell line derived from normal liver tissue, while it induced only modest effects in a number of hepatoma cell lines. The apoptotic effect was reduced by methyl-beta-cyclodextrin, a membrane cholesterol depletor, suggesting an interaction between anandamide and the membrane microdomains named lipid rafts. Anandamide effects were mediated by the production of ceramide, as demonstrated by experiments performed with the sphingomyelinase inhibitor, desipramine, or with the sphingomyelinase activator, melittin. This conclusion w…
Być kamieniem w mozaice, czyli o wartości własnej człowieka w pismach Edyty Stein (św. Teresy Benedykty od Krzyża)
2017
To describe important spiritual and philosophical issues Edith Stein used a symbol. The reason was her aesthetical sensitivity, but also, to some extent, her method of the phenomenological view. The definitions of the symbol used by the philosopher in the writings were introduced in the beginning. However, the main purpose of this article is the analysis of the symbolic stone. Recalling the context in the writings of Edith Stein and other texts that influenced her, one can find out that through these images she gets to the essence of all important aspects of the human being. Analyzing the symbol was tire attempt to show the extended reflection over the self-value of the woman, and then of a…
Neutral-current atmospheric neutrino flux measurement using neutrino-proton elastic scattering in Super-Kamiokande
2003
Recent results show that atmospheric $\nu_\mu$ oscillate with $\delta m^2 \simeq 3 \times 10^{-3}$ eV$^2$ and $\sin^2{2\theta_{atm}} \simeq 1$, and that conversion into $\nu_e$ is strongly disfavored. The Super-Kamiokande (SK) collaboration, using a combination of three techniques, reports that their data favor $\nu_\mu \to \nu_\tau$ over $\nu_\mu \to \nu_{sterile}$. This distinction is extremely important for both four-neutrino models and cosmology. We propose that neutrino-proton elastic scattering ($\nu + p \to \nu + p$) in water \v{C}erenkov detectors can also distinguish between active and sterile oscillations. This was not previously recognized as a useful channel since only about 2% …
Simultaneous measurement of the muon neutrino charged-current cross section on oxygen and carbon without pions in the final state at T2K
2020
Authors: K. Abe,56 N. Akhlaq,45 R. Akutsu,57 A. Ali,32 C. Alt,11 C. Andreopoulos,54,34 L. Anthony,21 M. Antonova,19 S. Aoki,31 A. Ariga,2 T. Arihara,59 Y. Asada,69 Y. Ashida,32 E. T. Atkin,21 Y. Awataguchi,59 S. Ban,32 M. Barbi,46 G. J. Barker,66 G. Barr,42 D. Barrow,42 M. Batkiewicz-Kwasniak,15 A. Beloshapkin,26 F. Bench,34 V. Berardi,22 L. Berns,58 S. Bhadra,70 S. Bienstock,53 S. Bolognesi,6 T. Bonus,68 B. Bourguille,18 S. B. Boyd,66 A. Bravar,13 D. Bravo Berguño,1 C. Bronner,56 S. Bron,13 A. Bubak,51 M. Buizza Avanzini ,10 T. Campbell,7 S. Cao,16 S. L. Cartwright,50 M. G. Catanesi,22 A. Cervera,19 D. Cherdack,17 N. Chikuma,55 G. Christodoulou,12 M. Cicerchia,24,† J. Coleman,34 G. Collazu…
Characterization of nuclear effects in muon-neutrino scattering on hydrocarbon with a measurement of final-state kinematics and correlations in charg…
2018
This paper reports measurements of final-state proton multiplicity, muon and proton kinematics, and their correlations in charged-current pionless neutrino interactions, measured by the T2K ND280 near detector in its plastic scintillator (C$_8$H$_8$) target. The data were taken between years 2010 and 2013, corresponding to approximately 6$\times10^{20}$ protons on target. Thanks to their exploration of the proton kinematics and of kinematic imbalances between the proton and muon kinematics, the results offer a novel probe of the nuclear-medium effects most pertinent to the (sub-)GeV neutrino-nucleus interactions that are used in accelerator-based long-baseline neutrino oscillation measureme…
Istutuspäällikkö Gaddin julkiset matkaraportit 1763–1765
2022
Artikkelissa tarkastellaan Inrikes Tidningarissa julkaistuja raportteja Pehr Adrian Gaddin (1727–1797) matkoista Suomessa vuosina 1763–1765. Tekstit sekä rikastavat käsitystä Gaddin toiminnasta istutuspäällikkönä että antavat esimerkin mahdollisesta julkisuuden käytöstä vapaudenajan lopun Ruotsissa.