Search results for "kasvaimet"

Esriinin merkitys syövässä

2014

Tutkimukseni selvittää esriinin tehtäviä ja säätelyä erityisesti syövän kannalta. Esriini kuuluu ERM-proteiiniperheeseen (esriini/radiksiini/moesiini). Nämä proteiinit tarttuvat toisaalta solun aktiinitukirankaan, toisaalta solukalvon reseptoreihin. Esriini vaikuttaa solutukirangan järjestäytymiseen ja solun kortikaalisiin muodonmuutoksiin. Voimistunut esriinin ekspressio korreloi tiettyjen syöpätyyppien maligniteettiin ja erityisesti metastointikykyyn. Esriinin tiedetään esimerkiksi olevan välttämätön osteosarkooman metastaasissa. Tutkimuksen tavoitteena oli selvittää Src-kinaasin katalysoiman fosforyloinnin merkitystä esriinin toiminnalle syöpään liittyvissä ilmiöissä, esim. invaasiossa j…

Development of DNA aptamers for visualization of glial brain tumors and detection of circulating tumor cells

2023

Here, we present DNA aptamers capable of specific binding to glial tumor cells in vitro, ex vivo, and in vivo for visualization diagnostics of central nervous system tumors. We selected the aptamers binding specifically to the postoperative human glial primary tumors and not to the healthy brain cells and meningioma, using a modified process of systematic evolution of ligands by exponential enrichment to cells; sequenced and analyzed ssDNA pools using bioinformatic tools and identified the best aptamers by their binding abilities; determined three-dimensional structures of lead aptamers (Gli-55 and Gli-233) with small-angle X-ray scattering and molecular modeling; isolated and identified mo…

Effects of the cancer and muscle growth on lipid metabolism in adipose tissue and skeletal muscle

2017

Tertiary lymphoid structures in pulmonary metastases of microsatellite stable colorectal cancer

2023

Tertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates located at sites of chronic inflammation and recognized as prognosticators in several cancers. We aimed to analyse the prognostic effect of TLSs in colorectal cancer (CRC) pulmonary metastases and primary tumours, with a comparison to the CD3+ and CD8+ cell density-based immune cell score (ICS). For TLS density and TLS maximum diameter analysis, 67 pulmonary metastases and 63 primary tumours were stained with haematoxylin and eosin. For ICS scoring and analysis, CD3 and CD8 immunohistochemistry was performed. Excellent interobserver agreement was achieved in all TLS measurements. Of all patients, 36 patients had low TLS den…