Search results for "kasvu"
showing 10 items of 210 documents
Liikunnanopettajien asenteet ja tietämys anabolisista androgeenisista steroideista ja kasvuhormonista
1998
Suunnittelijat innovaatiotoiminnan ja kasvun ytimessä
2010
Managing the complexity of green innovation
2022
PurposeGreen innovation can promote both environmental sustainability and economic growth. However, its development and implementation can be complex due to the need to align innovation activities within and across companies. In this study, the authors examined how this complexity can be managed by analyzing how individual companies combine different innovation activities to develop green innovation, and how companies along the value chain align to implement these innovations.Design/methodology/approachThe dataset comprises both interviews and a survey of senior executives from the Swedish wood construction industry. These data were first analyzed by using fuzzy set qualitative comparative …
Genetic and environmental effects on body mass index during adolescence: a prospective study among Finnish twins
2009
Objective: To study genetic and environmental factors affecting body mass index (BMI) and BMI phenotypic correlations across adolescence. Design: Prospective, population-based, twin cohort study. Participants and methods: We used twin modeling in 2413 monozygotic and same-sex and opposite-sex dizygotic Finnish twin pairs born in 1983–1987 and assessed using self-report questionnaires at 11–12, 14 and 17 years of age. Results: Heritability of BMI was estimated to be 0.58–0.69 among 11–12- and 14-year-old boys and girls, 0.83 among 17-year-old boys and 0.74 among 17-year-old girls. Common environmental effects shared by siblings were 0.15–0.24 among 11–12- and 14-year-old boys and girls but n…
Concurrent endurance and strength training : neuromuscular, cardiorespiratory and hormonal effects of the exercise order in previously untrained and …
2015
The aim of the present thesis was two-fold. First, to investigate physiological adaptations to concurrent endurance and strength training performed in the same session with different exercise orders (i.e. commencing training with endurance or strength, respectively; E+S vs. S+E) in previously untrained men (n=42) (study 1). Second, to examine physiological adaptations when strength training was always performed immediately after endurance running in the same session (E+S) compared to endurance training alone (E) in recreational endurance runners (n=30) (study 2). In study 1, training consisted of 2 - 3 weekly combined endurance cycling and mixed hypertrophic and maximal strength training se…
Mestaruus pääomana : huippu-urheilun tuottama pääoma yrittäjäksi ryhtymisen kannalta
2011
STAT5b is a key effector of NRG-1/ERBB4-mediated myocardial growth
2023
The growth factor Neuregulin-1 (NRG-1) regulates myocardial growth and is currently under clinical investigation as a treatment for heart failure. Here, we demonstrate in several in vitro and in vivo models that STAT5b mediates NRG-1/EBBB4-stimulated cardiomyocyte growth. Genetic and chemical disruption of the NRG-1/ERBB4 pathway reduces STAT5b activation and transcription of STAT5b target genes Igf1, Myc, and Cdkn1a in murine cardiomyocytes. Loss of Stat5b also ablates NRG-1-induced cardiomyocyte hypertrophy. Dynamin-2 is shown to control the cell surface localization of ERBB4 and chemical inhibition of Dynamin-2 downregulates STAT5b activation and cardiomyocyte hypertrophy. In zebrafish e…
Associations of IGF-1 and Adrenal Androgens with Cognition in Childhood
2019
Background: Little is known about the association between adrenarche and cognition in general populations of children. We therefore studied the associations of dehydroepiandrosterone sulfate (DHEAS), androstenedione (A4), testosterone, insulin-like growth factor-1 (IGF-1), and adrenarche with cognition among prepubertal children. Methods: These cross-sectional analyses are based on baseline data of the Physical Activity and Nutrition in Children Study. A total of 387 children (183 girls, 204 boys) were included in the analyses. Raven’s Coloured Progressive Matrices (CPM) score was used to assess nonverbal reasoning. Serum adrenal androgens and IGF-1 concentrations were measured and clinical…