Search results for "kasvutekijät"
showing 3 items of 3 documents
Systemic blockade of ACVR2B ligands protects myocardium from acute ischemia-reperfusion injury
2019
Activin A and myostatin, members of the transforming growth factor (TGF)-β superfamily of secreted factors, are potent negative regulators of muscle growth, but their contribution to myocardial ischemia-reperfusion (IR) injury is not known. The aim of this study was to investigate if activin 2B (ACVR2B) receptor ligands contribute to myocardial IR injury. Mice were treated with soluble ACVR2B decoy receptor (ACVR2B-Fc) and subjected to myocardial ischemia followed by reperfusion for 6 or 24 h. Systemic blockade of ACVR2B ligands by ACVR2B-Fc was protective against cardiac IR injury, as evidenced by reduced infarcted area, apoptosis, and autophagy and better preserved LV systolic function fo…
Yrittäjän persoonallisuus ja sen yhteys yrityksen kasvuun Big Five -teorian mukaan tarkasteltuna
2007
This doctoral thesis seeks to deepen the understanding of the factors that contribute to a firm’s growth from the perspective of the entrepreneur’s personality. The empirical data for this study was gathered through survey questionnaires distributed to members of entrepreneur organizations in Central Finland, Southern Ostrobothnia and Savonia (n=120, females 37%, males 63%, average age 50 years). The respondents were primarily founders of their own firms and approximately half worked in the service sector. In the quantitative analysis, the most common indicators of firm growth were used as dependent variables (i.e. sales, number of employees, fiscal results and net profit). Other factors af…
STAT5b is a key effector of NRG-1/ERBB4-mediated myocardial growth
2023
The growth factor Neuregulin-1 (NRG-1) regulates myocardial growth and is currently under clinical investigation as a treatment for heart failure. Here, we demonstrate in several in vitro and in vivo models that STAT5b mediates NRG-1/EBBB4-stimulated cardiomyocyte growth. Genetic and chemical disruption of the NRG-1/ERBB4 pathway reduces STAT5b activation and transcription of STAT5b target genes Igf1, Myc, and Cdkn1a in murine cardiomyocytes. Loss of Stat5b also ablates NRG-1-induced cardiomyocyte hypertrophy. Dynamin-2 is shown to control the cell surface localization of ERBB4 and chemical inhibition of Dynamin-2 downregulates STAT5b activation and cardiomyocyte hypertrophy. In zebrafish e…