Search results for "korvaushoito"

Marginaalin vangit? : opioidiriippuvaisten korvaushoidossa olevien kokemuksia marginaalisuudesta G. H. Meadin minäkäsityksen valossa

2014

Tutkin pro gradu -tutkielmassani opioidiriippuvaisten korvaushoidossa olevien kokemuksia marginaalisuudesta. Korvaushoito on opioidiriippuvaisten kuntouttavaa, päihteettömyyteen tähtäävää ja haittoja vähentävää hoitoa. Se on päihdehoidon muoto, joka yhdistää sekä lääkkeellisiä että psykososiaalisia menetelmiä. Marginaaleja jäsennetään usein valtavirtaan luettujen hyväksyttyjen arvojen, normien ja lakien noudattamisen kautta. Huumeidenkäyttäjät asettuvat marginaaliin paitsi normien rikkomisen perusteella, myös usein hyväksi katsottujen yhteisöjen ulkopuolisuuden perusteella. Myös korvaushoito itsessään on eräänlainen marginaali hoitomuotoon liittyvien kyseenalaistusten ja kiistanalaisuuden p…

Hallinnan näkökulmia huumeriippuvuuden hoitoon Suomessa vuosina 1965-2005

2011

Muscular transcriptome in postmenopausal women with or without hormone replacement.

2007

The loss of muscle mass and strength with aging is well characterized, but our knowledge of the molecular mechanisms underlying the development of sarcopenia remains incomplete. Although menopause is often accompanied with first signs of age-associated changes in muscle structure and function, the effects of hormone replacement therapy (HRT) or menopause-related decline in estrogen production in the muscles of postmenopausal women is not well understood. Furthermore the knowledge of the global transcriptional changes that take place in skeletal muscle in relation to estrogen status has thus far been completely lacking. We used a randomized double-blinded study design together with an explor…

Global gene expression profiles in skeletal muscle of monozygotic female twins discordant for hormone replacement therapy

2010

Aging is accompanied by inexorable loss of muscle tissue. One of the underlying causes for this is the massive change in the hormonal milieu of the body. The role of a female sex steroid – estrogen – in these processes is frequently neglected, although the rapid decline in its production coincides with a steep deterioration in muscle performance. We recruited 54- to 62-year-old monozygotic female twin pairs discordant for postmenopausal hormone replacement therapy (HRT, n = 11 pairs; HRT use 7.3 ± 3.7 years) from the Finnish Twin Cohort to investigate the association of long-term, estrogen-based HRT with skeletal muscle transcriptome. Pathway analysis of muscle transcript profiles revealed …

Effects of combined hormone replacement therapy or its effective agents on the IGF-1 pathway in skeletal muscle.

2010

Objectives To investigate the effects of combined hormone replacement therapy (HRT) and its effective agents on the IGF-1 signaling pathway. Design and methods To examine the effects of HRT on skeletal muscle in vivo, we utilized pre- and post-intervention samples from a randomized double blinded trial with 50–57-year-old women. The intervention included the year-long use of either HRT preparation (2 mg 17β-estradiol, E2; 1 mg norethisterone acetate, NETA, n = 10) or placebo (CO, n = 9). Microarray technology and quantitative PCR (qPCR) were used to study the expression of insulin-like growth factor I (IGF-1) and its splice variants as well as IGF-1 receptor, Akt1, mTOR, FOXO1, FOXO3, atrog…

Power training and postmenopausal hormone therapy affect transcriptional control of specific co-regulated gene clusters in skeletal muscle

2010

At the moment, there is no clear molecular explanation for the steeper decline in muscle performance after menopause or the mechanisms of counteractive treatments. The goal of this genome-wide study was to identify the genes and gene clusters through which power training (PT) comprising jumping activities or estrogen containing hormone replacement therapy (HRT) may affect skeletal muscle properties after menopause. We used musculus vastus lateralis samples from early stage postmenopausal (50–57 years old) women participating in a yearlong randomized double-blind placebo-controlled trial with PT and HRT interventions. Using microarray platform with over 24,000 probes, we identified 665 diffe…

Terveydenhuoltopalvelujen kaupallistuminen ja kuluttajanäkökulma : esimerkkinä lääkäreiden suhtautuminen vaihdevuosien hoitokäytäntöjen markkinointiin

1998

Hyppelyharjoittelun ja estrogeeninkorvaushoidon vaikutus alaraajojen ojennustehoon ja juoksunopeuteen postmenopausaalisilla naisilla : vuoden randomi…

1999

Influence of long-term postmenopausal hormone replacement therapy on estimated structural bone strength: A study in discordant monozygotic twins.

2011

Although postmenopausal hormone-replacement therapy (HRT) is known to prevent fractures, knowledge on the influence of long-term HRT on bone strength and its determinants other than areal bone mineral density is scarce. This study used a genetically controlled design with 24 monozygotic female twin pairs aged 54 to 72 years in which one cotwin was using HRT (mean duration 8 years) and the other had never used HRT. Estimated bone strength, cross-sectional area, volumetric bone mineral density, bone mineral mass, and cross-sectional density and mass distributions were assessed in the tibial shaft, distal tibia, and distal radius with peripheral computed tomography (pQCT). In the tibial shaft,…

Implementation of Substitution Treatment in Finland: Beyond Rationalisation and Medicalisation

2011

AIMS Finnish treatment of drug abuse has during the last two decades shifted from a predominantly psychosocial approach to a more medical mode. This is especially evident in the rapid implementation of substitution treatments (STs). My aim is to show that labelling this development as ‘medicalisation’ or ‘rationalisation’ as a form of medical progress will not increase our understanding of the change. MATERIAL AND DESIGN I analysed texts from several periodicals with psychosocial, social policy and medical perspectives between 1997 and 2005. Four basic conceptual and argumentative underpinnings emerged which gave credence to the medical and rationalapproach, and the validity of these four e…