Search results for "kudokset"
showing 10 items of 35 documents
Bioactive glass ions induce efficient osteogenic differentiation of human adipose stem cells encapsulated in gellan gum and collagen type I hydrogels
2019
Abstract Background Due to unmet need for bone augmentation, our aim was to promote osteogenic differentiation of human adipose stem cells (hASCs) encapsulated in gellan gum (GG) or collagen type I (COL) hydrogels with bioactive glass (experimental glass 2-06 of composition [wt-%]: Na2O 12.1, K2O 14.0, CaO 19.8, P2O5 2.5, B2O3 1.6, SiO2 50.0) extract based osteogenic medium (BaG OM) for bone construct development. GG hydrogels were crosslinked with spermidine (GG-SPD) or BaG extract (GG-BaG). Methods Mechanical properties of cell-free GG-SPD, GG-BaG, and COL hydrogels were tested in osteogenic medium (OM) or BaG OM at 0, 14, and 21 d. Hydrogel embedded hASCs were cultured in OM or BaG OM fo…
Mechanical Coupling Between Muscle-Tendon Units Reduces Peak Stresses
2017
The presence of mechanical linkages between synergistic muscles and their common tendons may distribute forces among the involved structures. We review studies, using humans and other animals, examining muscle and tendon interactions and discuss the hypothesis that connections between muscle bellies and within tendons may serve as a mechanism to distribute forces and mitigate peak stresses. peerReviewed
Comparison of muscle and hair stable isotope ratios in three phocid seals
2020
Kovatehoisen, iskutyyppisen harjoittelun vaikutukset reisiluun kaulan lujuuteen lievää polven nivelrikkoa sairastavilla postmenopausaali-ikäisillä na…
2013
TIIVISTELMÄ Kovatehoisen, iskutyyppisen harjoittelun vaikutukset reisiluun kaulan lujuuteen lievää polven nivelrikkoa sairastavilla postmenopausaali-ikäisillä naisilla. Satunnaistettu kontrolloitu tutkimus. Janhunen, Eija Fysioterapian Pro Gradu- tutkielma Jyväskylän yliopisto, Liikuntatieteellinen tiedekunta, Terveystieteiden laitos 2013 Sivuja 79 Ohjaajat: Prof. Ari Heinonen ja THM Juhani Multanen, Jyväskylän Yliopisto, Terveystieteiden laitos Tämän satunnaistetun kontrolloidun tutkimuksen tarkoituksena oli tutkia 12 kuukautta kestäneen iskutyyppisen harjoittelun vaikutuksia reisiluun kaulan lujuuteen lievää polven nivelrikkoa sairastavilla postmenopausaali-ikäisillä naisilla. Kahdeksanky…
Biological basis of bone strength : Anatomy, physiology and measurement
2020
Understanding how bones are innately designed, robustly developed and delicately maintained through intricate anatomical features and physiological processes across the lifespan is vital to inform our assessment of normal bone health, and essential to aid our interpretation of adverse clinical outcomes affecting bone through primary or secondary causes. Accordingly this review serves to introduce new researchers and clinicians engaging with bone and mineral metabolism, and provide a contemporary update for established researchers or clinicians. Specifically, we describe the mechanical and non-mechanical functions of the skeleton; its multidimensional and hierarchical anatomy (macroscopic, m…
Suolistomikrobiston koostumuksen erot HCR- ja LCR -rotilla ja yhteys viskeraalisen rasvakudoksen geenien ilmentymiseen
2016
Hongisto, T. 2016. Suolistomikrobiston koostumuksen erot HCR- ja LCR -rotilla ja yhteys viskeraalisen rasvakudoksen geenien ilmentymiseen. Terveystieteiden laitos, Jyväskylän yliopisto, Liikuntalääketieteen pro gradu -tutkielma, 62s, 4 liitettä. Suolistomikrobistolla on osoitettu olevan merkittäviä vaikutuksia isännän terveyteen. Se vaikuttaa muun muassa lihavuuden kehittymiseen. Elimistön rasvan määrän vaihtelun on puolestaan havaittu vaikuttavan suolistomikrobiston koostumukseen. Sekä synnynnäisen että hankitun aerobisen kapasiteetin yhteyttä suolistomikrobistoon ei ole juuri tutkittu. Tämän tutkimuksen tarkoituksena on selvittää suolistomikrobiston koostumuksen ja viskeraalisen rasvakudo…
Characterisation of peripheral bone mineral density in youth at risk of secondary osteoporosis : a preliminary insight
2020
Objectives: To describe peripheral long bone material and structural differences in youth at risk of secondary osteoporosis across disease-specific profiles. Methods: Upper- and lower limbs of children and adolescents were scanned at 4% distal and 66% mid-shaft sites using peripheral Quantitative Computed Tomography sub-categorised as (1) increased risk of secondary osteoporosis (neuromuscular disorders; chronic diseases; endocrine diseases; inborn errors of metabolism; iatrogenic conditions), (2) low motor competence and (3) non-affected controls. Results: Children with disease-specific profiles showed a range of bone deficits compared to the control group with these predominantly indicate…
Reliability and methodology of quantitative assessment of harvested and unharvested patellar tendons of ACL injured athletes using ultrasound tissue …
2019
Ultrasound tissue characterization (UTC) imaging has been previously used to describe the characteristics of patellar and Achilles tendons. UTC imaging compares and correlates successive ultrasonographic transverse tendon images to calculate the distribution of four color-coded echo-types that represent different tendon tissue types. However, UTC has not been used to describe the characteristics of patellar tendons after anterior cruciate ligament reconstruction (ACLR). The aim of this cross-sectional study was to assess the intra and inter-rater reliability of the UTC in unharvested and harvested patellar tendons of patients undergoing ACLR. Intra and inter-rater reliability of both UTC da…
Bone mineral density, structure, distribution and strength in men with prostate cancer treated with androgen deprivation therapy
2019
Androgen deprivation therapy (ADT) improves survival in men with advanced prostate cancer (PCa), but has been associated with compromised skeletal health and increased fracture risk. However, limited previous research has investigated determinants of bone strength beyond DXA-derived areal bone mineral density (aBMD) in this population group. The aim of this cross-sectional study was to investigate the effects of ADT in men with PCa on BMD, bone structure, estimates of whole bone strength and cortical bone distribution. A total of 70 ADT-treated men, 52 PCa controls and 70 healthy controls had DXA lumbar spine and proximal femur aBMD and pQCT distal (4%) and proximal (66%) tibia and radius c…
Identifying and Assessing Inter-Muscular Fat at the Distal Diaphyseal Femur Measured by Peripheral Quantitative Computed Tomography (pQCT)
2021
INTRODUCTION Inter/intramuscular fat can be assessed with peripheral Quantitative Computed Tomography (pQCT) and is of interest as an indicator of ‘muscle quality’. Typical pQCT scan sites (forearm, lower leg) have a low amount of inter/intramuscular fat, however distal diaphyseal femur scan sites with conspicuous inter/intramuscular fat have been identified as potentially more prudent scan sites, even in healthy adolescents. However, current state of the art analysis methods require labour-intensive manual segmentation of the scan. The purpose of the present study was to evaluate the reliability of a novel open source automated enclosing convex polygon approach (source code https://github.…