Search results for "kylä"
showing 10 items of 821 documents
The emergence of Vibrio pathogens in Europe : ecology, evolution, and pathogenesis (Paris, 11-12th March 2015)
2015
Global change has caused a worldwide increase in reports of Vibrio-associated diseases with ecosystem-wide impacts on humans and marine animals. In Europe, higher prevalence of human infections followed regional climatic trends with outbreaks occurring during episodes of unusually warm weather. Similar patterns were also observed in Vibrio-associated diseases affecting marine organisms such as fish, bivalves and corals. Basic knowledge is still lacking on the ecology and evolutionary biology of these bacteria as well as on their virulence mechanisms. Current limitations in experimental systems to study infection and the lack of diagnostic tools still prevent a better understanding of Vibrio…
Decreased temperature increases the expression of a disordered bacterial late embryogenesis abundant (LEA) protein that enhances natural transformati…
2021
Late embryogenesis abundant (LEA) proteins are important players in the management of responses to stressful conditions, such as drought, high salinity, and changes in temperature. Many LEA proteins do not have defined three-dimensional structures, so they are intrinsically disordered proteins (IDPs) and are often highly hydrophilic. Although LEA-like sequences have been identified in bacterial genomes, the functions of bacterial LEA proteins have been studied only recently. Sequence analysis of outer membrane interleukin receptor I (BilRI) from the oral pathogen Aggregatibacter actinomycetemcomitans indicated that it shared sequence similarity with group 3/3b/4 LEA proteins. Comprehensive …
Yliopistouudistuksen diskursiivinen rakentuminen Jyväskylän yliopistoyhteisössä 2009-2010
2012
Pro gradu -tutkielmassani tarkastelen Suomen uudelle yliopistolaille (2009) annettuja ristiriitaisia merkityksiä Jyväskylän yliopistoyhteisössä. Yliopistouudistus toi mukanaan merkittäviä taloudellisia ja ideologisia muutoksia suomalaiseen yliopistokenttään, ja siksi muutoksista on kiistelty paljon. Keskusteluissa on kuitenkin luonnehtinut ”yliopistouudistus hyvänä vs. pahana” -asettelu, joka ei ole paras mahdollinen tapa lähestyä uudistuksen jälkiteollisia syitä ja moninaisia seurauksia. Diskurssintutkimuksen näkökulmasta yliopistouudistuskeskustelut ovat kielellisten ”totuuksien” luomista siitä, mikä on suomalaisten yliopistojen tarkoitus nyky-yhteiskunnassa. Näillä ”totuuksilla” eli ylio…
How do community development activities affect the construction of rural places? : A case study from Finland
2019
Community‐based development practices have been seen as the prevailing paradigm for rural development. Rural community development practices are employed especially through local non‐governmental organisations, such as village associations, to ensure that rural communities are vital and attractive places to live. In this article, we explore how community development practices affect and shape rural places. The data were collected in three Finnish villages that each have an active village association and that have adopted community development practices as their method of keeping their village viable. According to the results of our study, the impacts of community practices on rural places c…
Erasmus-vaihdossa Puolasta
2014
Tietue 2011/3
2011
Tapaustutkimus Jyväskylä Sinfoniasta
2015
Taidemusiikin markkinointiviestintä ilmiönä ei ole uusi: sen juuret ovat 1800-luvulla alkaneessa taidemusiikin murroksessa. Taidemusiikin markkinointiviestintä on verrattavissa muihin musiikkia koskeviin teksteihin. Keskeistä taidemusiikin markkinoinnissa on se, että musiikkia koskeva tieto halutaan saada siitä kiinnostuneen yleisön keskuuteen. Uutta on kulttuurinen ja teknologinen ympäristö, jossa viestejä lähetetään. Näiden muutosten voisi olettaa vaikuttaneen taidemusiikkia koskevaan markkinointiviestintään. Tämän tutkimuksen tarkoituksena on selvittää, millaista on taidemusiikkia koskeva markkinointiviestintä sosiaalisessa mediassa. Lisäksi halutaan saada selville lähettäjän näkökulma t…
Inactivation of folylpolyglutamate synthetase Met7 results in genome instability driven by an increased dUTP/dTTP ratio
2020
AbstractThe accumulation of mutations is frequently associated with alterations in gene function leading to the onset of diseases, including cancer. Aiming to find novel genes that contribute to the stability of the genome, we screened the Saccharomyces cerevisiae deletion collection for increased mutator phenotypes. Among the identified genes, we discovered MET7, which encodes folylpolyglutamate synthetase (FPGS), an enzyme that facilitates several folate-dependent reactions including the synthesis of purines, thymidylate (dTMP) and DNA methylation. Here, we found that Met7-deficient strains show elevated mutation rates, but also increased levels of endogenous DNA damage resulting in gross…