Search results for "kyy"
showing 10 items of 296 documents
DNA-molekyylin sähkönjohtavuusmittaukset
2012
DNA-molekyylien sähkönjohtavuus on askarruttanut tutkijoita jo usean vuosikymmenen ajan. Periaatteessa DNA-molekyylin sähköiset mittaukset eivät eroa mitenkään minkä tahansa sähkökomponenttien mittauksesta. Useat tutkimukset ovat kuitenkin osoittaneet, että hyvin monet parametrit mittausjärjestelyissä vaikuttavat saatuihin tuloksiin merkittävästi, joten mitään yksiselitteistä vastausta DNA:n sähkönjohtavuuteen ei ole saatu. Tämä opinnäyte keskittyykin näissä erityyppisissä mittauksissa käytettyjen mittausjärjestelyjen tarkasteluun ja saatuihin tuloksiin. Tutkimukset jaotellaan epäsuoriin ja suoriin mittauksiin, joiden erityispiirteet pyritään selvittämään. Lisäksi mittausten tuloksia pyritä…
Inverse Conformational Selection in Lipid–Protein Binding
2021
International audience; Interest in lipid interactions with proteins and other biomolecules is emerging not only in fundamental biochemistry but also in the field of nanobiotechnology where lipids are commonly used, for example, in carriers of mRNA vaccines. The outward-facing components of cellular membranes and lipid nanoparticles, the lipid headgroups, regulate membrane interactions with approaching substances, such as proteins, drugs, RNA, or viruses. Because lipid headgroup conformational ensembles have not been experimentally determined in physiologically relevant conditions, an essential question about their interactions with other biomolecules remains unanswered: Do headgroups excha…
Manipulating mtDNA in vivo reprograms metabolism via novel response mechanisms.
2019
Mitochondria have been increasingly recognized as a central regulatory nexus for multiple metabolic pathways, in addition to ATP production via oxidative phosphorylation (OXPHOS). Here we show that inducing mitochondrial DNA (mtDNA) stress in Drosophila using a mitochondrially-targeted Type I restriction endonuclease (mtEcoBI) results in unexpected metabolic reprogramming in adult flies, distinct from effects on OXPHOS. Carbohydrate utilization was repressed, with catabolism shifted towards lipid oxidation, accompanied by elevated serine synthesis. Cleavage and translocation, the two modes of mtEcoBI action, repressed carbohydrate rmetabolism via two different mechanisms. DNA cleavage activ…
John Dewey’s notion of social intelligence
2019
This chapter focuses on Deweyan understanding of intelligence as fundamentally social. This understanding differs from the common conceptions of intelligence as a feature of an isolated individual and/or as a possession of an elite. Starting with a look at the relevance of reconceptualizing intelligence, the chapter continues by describing how, according to Dewey’s theory, intelligence forms, manifests and cumulates in interactions. It then discusses the presumable implications of Dewey’s theory in terms of the contextuality of intelligent action, the importance of taking relevant experience-based information into account, the use of a particular method of inquiry, and modification of educa…
Reactions of Alkenes and Alkynes with an Acyclic Silylene and Heavier Tetrylenes under Ambient Conditions
2014
Cycloaddition reactions of the acyclic silylene Si(SAriPr4)2 (AriPr4 = C6H3-2,6(C6H3-2,6-iPr2)2) with a variety of alkenes and alkynes were investigated. Its reactions with the alkynes phenylacetylene and diphenylacetylene and the diene 2,3-dimethyl-1,3-butadiene yielded silacycles (AriPr4S)2tiebar above startSi(CH═tiebar above endCPh) (1), (AriPr4S)2tiebar above startSi(PhC═tiebar above endCPh) (2), and (AriPr4S)2tiebar above startSiCH2CMeCMetiebar above endCH2 (3) at ambient temperature. The compounds were characterized by X-ray crystallography, 1H, 13C, and 29Si NMR spectroscopy, and IR spectroscopy. No reaction was observed with more substituted alkenes such as propene, (Z)-2-butene, te…
Enhanced Surface Ligands Reactivity of Metal Clusters by Bulky Ligands for Controlling Optical and Chiral Properties.
2021
Surface ligands play critical roles in determining the surface properties of metal clusters. However, modulating the properties and controlling the surface structure of clusters through surface‐capping agent displacement remain a challenge. In this work, a silver cluster, [Ag 14 (SPh(CF 3 ) 2 ) 12 (PPh 3 ) 4 (DMF) 4 ] ( Ag 14 ‐DMF , where HSPh(CF 3 ) 2 is 3,5‐bis(trifluoromethyl)benzenethiol, PPh 3 is triphenylphosphine and DMF is N,N‐Dimethylformamide), with weakly coordinated DMF ligands on the surface silver sites, was synthesized by using a mixed ligands strategy (bulky thiolates, phosphines and small solvents). The as‐prepared Ag 14 ‐DMF is a racemic mixture of chiral molecules. Owing …
Digitaalisen markkinointiviestinnän osaaminen ja kyvykkyydet
2017
Tutkielma käsittelee digitaalisen markkinointiviestinnän osaamista ja kyvykkyyksiä. Tutkielman tarkoitus on selvittää millaisia digitaalisia markkinointiviestintä kyvykkyyksiä ja osaamista organisaatioilta pitäisi löytyä, jotta se voi menestyä. Jotta digitaalisen markkinointiviestintä kyvykkyyksien ja osaamisen voidaan ymmärtää, on aluksi ymmärrettävä mitä digitaalisella markkinointiviestinnällä, resursseilla, kyvykkyydellä tarkoitetaan. Tässä kandidaatintutkielmassa pyritään selittämään nämä kyseiset termit kirjallisuuskatsauksen avulla. This thesis investigates digital marketing communications competence and capabilities. It aims to examine what kind of capabilities and competencies organ…
Interplay of spin-dependent delocalization and magnetic anisotropy in the ground and excited states of [Gd2@C78]− and [Gd2@C80]−
2017
The magnetic properties and electronic structure of the ground and excited states of two recently characterized endohedral metallo-fullerenes, [Gd2@C78]- (1) and [Gd2@C80]- (2), have been studied by theoretical methods. The systems can be considered as [Gd2]5+ dimers encapsulated in a fullerene cage with the fifteen unpaired electrons ferromagnetically coupled into an S = 15/2 high-spin configuration in the ground state. The microscopic mechanisms governing the Gd-Gd interactions leading to the ferromagnetic ground state are examined by a combination of density functional and ab initio calculations and the full energy spectrum of the ground and lowest excited states is constructed by means …
Policy Alienation in Frontline Social Work – A Study of Social Workers’ Responses to a Major Anticipated Social and Health Care Reform in Finland
2021
Change in the policy and ideology governing social and health care has been much debated in the Western welfare states, including in Finland, where the public sector has witnessed a shift towards a market and managerial ideology in a climate of austerity. These changes affect organisations as well as individual workers. Social workers implement social policies in their daily work, and are thus positioned in between policies and clients. This may expose them to feelings of unease in the implementation of certain policies. In this study, we apply the policy alienation framework of Tummers and colleagues (2009. “Policy Alienation of Public Professionals: Application in a new Public Management …
Polariton response in the presence of Brownian dissipation from molecular vibrations
2020
We study the elastic response of a stationarily driven system of a cavity field strongly coupled with molecular excitons, taking into account the main dissipation channels due to the finite cavity linewidth and molecular vibrations. We show that the frequently used coupled oscillator model fails in describing this response especially due to the non-Lorentzian dissipation of the molecules to their vibrations. Signatures of this failure are the temperature dependent minimum point of the polariton peak splitting, uneven polariton peak height at the minimum splitting, and the asymmetric shape of the polariton peaks even at the experimentally accessed "zero-detuning" point. Using a rather generi…