Search results for "label"
showing 10 items of 797 documents
Are the leukocyte telomere length attrition and telomerase activity alteration potential predictor biomarkers for sporadic TAA in aged individuals?
2014
A large variability in occurrence, complications, and age/gender manifestations characterizes individual susceptibility of sporadic thoracic aortic aneurysms (TAA), even in subjects with the same risk factor profiles. The reasons are poorly understood. On the other hand, TAA pathophysiology mechanisms remain unclear than those involved in abdominal aorta aneurysms. However, recent evidence is suggesting a crucial role of biological ageing in inter-individual risk variation of cardiovascular diseases, including sporadic TAA. Biological age rather than chronological age is a better predictor of vascular risk. Relevant assumptions support this concept. In confirming this evidence and our preli…
Increased Expression of Integrin and Receptor Tyrosine Kinase Genes During Autograft Fusion in the SpongeGeodia cydonium
1999
Recently cDNAs coding for cell surface molecules have been isolated from sponges. The molecules for alpha-integrin, galectin, and receptor tyrosine kinase (RTK), obtained from the marine sponge, Geodia cydonium, have been described earlier. In the present study also the cDNA for one putative beta-integrin has been identified from G. cydonium. The deduced aa sequence comprises the characteristic signatures, found in other metazoan beta-integrin molecules; the estimated size is 95,215 Da. To obtain first insights into the molecular events which proceed during autograft fusion, the expressions of these genes were determined on transcriptional and translational level. The cDNAs as well as antib…
Key Disulfide Bonds in an Insect Hormone Binding Protein: cDNA Cloning of a Juvenile Hormone Binding Protein of Heliothis virescens and Ligand Bindin…
1995
The hemolymph juvenile hormone binding protein (JHBP) from the early fifth instar larvae of Heliothis virescens (Lepidoptera, Noctuidae) has been purified, and three cDNA clones for this protein have been isolated from a fat body cDNA library constructed in bacteriophage λZAP XR. The deduced amino acid sequence of the full-length clone predicts a mature protein consisting of 224 residues, a molecular mass of 24 976 Da, and a p/ of 5.29. Comparison of the amino acid sequence to that of the previously described JHBP from Manduca sexta shows 51 % overall identity with highly conserved N- and C-terminal regions. One of the three clones bound photoactivatable analogs of juvenile hormones with mu…
Modulāra sistēmas dizaina ieviešana "white-label" mobilo lietotņu izstrādei
2022
“White-label” mobilo lietotņu izstrāde ir izstrādes stratēģija, kas sevī ietver bāzes koda izstrādi un bāzes pielāgošanu, izveidojot dažādas programmas dažādu klientu prasībām. Šādai stratēģijai palīdz pielāgojama sistēmas struktūra un modulāra dizaina ieviešana padara sistēmu pielāgojamāku. Darbā tiks apskatīti ieteikumi modulāra dizaina ieviešanai un analizēti attiecībā pret “white-label” lietotņu izstrādes pieredzi.
Pulsed EPR determination of water accessibility to spin-labeled amino acid residues in LHCIIb.
2009
Membrane proteins reside in a structured environment in which some of their residues are accessible to water, some are in contact with alkyl chains of lipid molecules, and some are buried in the protein. Water accessibility of residues may change during folding or function-related structural dynamics. Several techniques based on the combination of pulsed electron paramagnetic resonance (EPR) with site-directed spin labeling can be used to quantify such water accessibility. Accessibility parameters for different residues in major plant light-harvesting complex IIb are determined by electron spin echo envelope modulation spectroscopy in the presence of deuterated water, deuterium contrast in …
Devianze sessuali
2021
La sessualità è una delle dimensioni umane che hanno ricevuto maggiori forme di controllo, regolamentazione e normalizzazione. In particolare, essa è divenuta argomento di studio tramite approcci essenzialisti riconducibili al concetto di scientia sexualis, che proponeva una sessualità monolitica, ancorata ai concetti di giusto e sbagliato, morale e immorale, normale e anormale. dipendentemente dalle culture e organizzazioni di riferimento. Ancora oggi, nonostante le riflessioni in chiave simbolico-interazionista offerta da autori quali Garfinkel, Goffman e Simon e Gagnon, la sessualità appare regolamentata dal discorso medico e legata a doppio nodo dalla dimensione morale. Anche le discipl…
Hybrid Chelator-Based PSMA Radiopharmaceuticals: Translational Approach
2021
(1) Background: Prostate-specific membrane antigen (PSMA) has been extensively studied in the last decade. It became a promising biological target in the diagnosis and therapy of PSMA-expressing cancer diseases. Although there are several radiolabeled PSMA inhibitors available, the search for new compounds with improved pharmacokinetic properties and simplified synthesis is still ongoing. In this study, we developed PSMA ligands with two different hybrid chelators and a modified linker. Both compounds have displayed a promising pharmacokinetic profile. (2) Methods: DATA5m.SA.KuE and AAZTA5.SA.KuE were synthesized. DATA5m.SA.KuE was labeled with gallium-68 and radiochemical yields of various…
In vivo comparison of DOTA based 68Ga-labelled bisphosphonates for bone imaging in non-tumour models.
2013
Bone metastases are a class of cancerous metastases that result from the invasion of a tumor into bone. The solid mass which forms inside the bone is often associated with a constant dull ache and severe spikes in pain, which greatly reduce the quality of life of the patient. Numerous (99m)Tc-labeled bisphosphonate functionalised complexes are well established tracers for bone metastases imaging. The objective of this research was to evaluate the pharmacokinetics and behaviour of three DOTA based bisphosphonate functionalised ligands (BPAMD, BPAPD and BPPED), using both (68)Ga μ-PET in vivo imaging and ex vivo biodistribution studies in healthy Wistar rats. The compounds were labelled with …
A class of label-correcting methods for the K shortest paths problem
2001
In this paper we deal with the problem of finding the first K shortest paths from a single origin node to all other nodes of a directed graph. In particular, we define the necessary and sufficient conditions for a set of distance label vectors, on the basis of which we propose a class of methods which can be viewed as an extension of the generic label-correcting method for solving the classical single-origin all-destinations shortest path problem. The data structure used is characterized by a set of K lists of candidate nodes, and the proposed methods differ in the strategy used to select the node to be extracted at each iteration. The computational results show that: 1. some label-correct…
Periodicity vectors for labelled trees
2003
AbstractThe concept of a periodicity vector is introduced in the context of labelled trees, and some new periodicity theorems are obtained. These results constitute generalizations of the classical periodicity theorem of Fine and Wilf for words. The concept of a tree congruence is also generalized and the isomorphism between the lattice of tree congruences and the lattice of unlabelled trees (prefix codes) is established.