Search results for "language use"
showing 10 items of 5440 documents
Deciphering the Roles of Innate Lymphoid Cells in Cancer
2019
Cancer is a complex disease and the role played by innate lymphoid cells (ILCs) in cancer development has begun to be uncovered over recent years. We aim to provide an exhaustive summary of the knowledge acquired on the role of ILCs in cancer. ILCs are classified into 3 different categories, ILC1s, ILC2s, and ILC3s, each encompassing specific and unique functions. ILC1s exhibit NK cells characteristics and can exert anti-tumor functions, but surprisingly their IFNγ production is not associated with a better immune response. In response to TGF-β or IL-12, ILC1s were shown to exert pro-tumor functions and to favor tumor growth. ILC2s role in cancer immune response is dependent on cytokine con…
Immunosenescence and lymphomagenesis
2018
Abstract One of the most important determinants of aging-related changes is a complex biological process emerged recently and called “immunosenescence”. Immunosenescence refers to the inability of an aging immune system to produce an appropriate and effective response to challenge. This immune dysregulation may manifest as increased susceptibility to infection, cancer, autoimmune disease, and vaccine failure. At present, the relationship between immunosenescence and lymphoma in elderly patients is not defined in a satisfactory way. This review presents a brief overview of the interplay between aging, cancer and lymphoma, and the key topic of immunosenescence is addressed in the context of t…
Una poética de las ruinas. Testimonio y alegoría de Aníbal Quijada
2009
El texto de Aníbal Quijada Cerco de púas ejemplifica la doble vinculación de los testimonios del exilio chileno. Por una parte, éstos debieron inscribirse en las estrategias internacionales de denuncia contra la dictadura militar y, por otra, la comunidad cultural latinoamericana hizo de los testimonios un elemento esencial para la redefinición del concepto mismo de lo literario. El testimonio de Quijada desarrolla, en ese contexto, unas estrategias narrativas y de representación que alejan su textura de la mayoría de los testimonios de la época.The text of Aníbal Quijada Cerco de púas, is a good example of the double filiation of the testimonies of Chilean exile. In one hand these testimon…
Mucins as a New Frontier in Pulmonary Fibrosis
2019
Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pulmonary disease with a median survival of 3–5 years after diagnosis. Recent evidence identifies mucins as key effectors in cell growth and tissue remodeling processes compatible with the processes observed in IPF. Mucins are classified in two groups depending on whether they are secreted (secreted mucins) or tethered to cell membranes (transmembrane mucins). Secreted mucins (MUC2, MUC5AC, MUC5B, MUC6-8 and MUC19) are released to the extracellular medium and recent evidence has shown that a promoter polymorphism in the secreted mucin MUC5B is associated with IPF risk. Otherwise, transmembrane mucins (MUC1, MUC3,…
All-Possible-Couplings Approach to Measuring Probabilistic Context.
2013
From behavioral sciences to biology to quantum mechanics, one encounters situations where (i) a system outputs several random variables in response to several inputs, (ii) for each of these responses only some of the inputs may "directly" influence them, but (iii) other inputs provide a "context" for this response by influencing its probabilistic relations to other responses. These contextual influences are very different, say, in classical kinetic theory and in the entanglement paradigm of quantum mechanics, which are traditionally interpreted as representing different forms of physical determinism. One can mathematically construct systems with other types of contextuality, whether or not …
Recursos mediáticos en la práctica educativa de E/LE en la Universidad de Relaciones Internacionales de Moscú (MGIMO)
2017
Resumen: Este trabajo está dedicado a compartir la experiencia de la práctica didáctica del uso de los recursos mediáticos en clase de E/LE. Analizamos la eficacia de tipos de materiales audiovisuales en la aplicación al proceso educativo tanto en el marco del curso general de los niveles A1-A2, B1-B2, como en el marco del español con fines específicos (B2-C1). En este trabajo exponemos las técnicas utilizadas en la MGIMO con apoyo de recursos mediáticos como uno de los mejores métodos para transmitir la lengua en un contexto real, explorando sus peculiaridades lingüísticas y extralingüísticas.Palabras clave: texto mediático, recursos audiovisuales, medios de comunicación, Español con Fines…
The Psychic Life and Creativity of the Forms of Life. Some Remarks on Wittgenstein’s Philosophy of Psychology
2015
Wittgenstein’s later philosophy addresses the subject of connection between the psychic life of the individual and social context, represented by language games which are played within a form of life. Sensations and passions are part of the psychic life of the individual; far from being hidden psychological objects of a private Cartesian, they are inseparable from their social redefinition. In fact, they become visible in the context of the game. Wittgenstein argues that there is a transformation of subjective psychic life by learning language games. The psychic life of the individual is then re-organized by learning a socially defined, characteristic behaviour pattern. However, the learnin…
Cruising y e-citas: un nuevo contexto para los encuentros sexuales entre hombres jóvenes que tienen sexo con hombres
2015
Resumen El objetivo de este artículo es el de explorar el papel que juega, en la actualidad, la irrupción de la mediación tecnológica de la información y la comunicación en la configuración de nuevos contextos para la relación sexual. En concreto, hemos explorado una práctica determinada, el cruising, entre hombres jóvenes que tienen sexo con hombres contactado a través de las e-citas. Se ha apostado por la metodología cualitativa con la intención de recopilar los discursos sobre sexualidad, riesgos y salud que se generan y construyen entre el grupo de iguales. Según extraemos de nuestro estudio, el nuevo marco que confiere esta tecnología estaría caracterizado por (a) una mayor accesibilid…
SCIROCCO tool to support knowledge transfer in integrated care
2019
Background: Knowledge transfer has been well recognised as an effective enabler to access existing evidence and learning on integrated care. It requires dedicated support to ensure that the flow of appropriate information and knowledge between adopting and transferring entities is tailored appropriately to the context and maturity of the adopting system. SCIROCCO is an online participatory tool that helps stakeholders to understand: 1) The context requirements of a particular good practice that is considered for adoption; 2) The level of maturity required for a health and social care system to adopt and scale up integrated care; 3) The actions that more progressive regions have taken to be …
Nurses' Experiences of Caring for Older Persons in Transition to Receive Homecare: Being Somewhere in between Competing Values
2013
Older persons in transition to need professional care in their homes will constitute a large group in municipalities in the future. The aim of this study was to obtain insight into nurses' experiences and perceptions of caring for patients in transition to receive homecare. Eleven home nurses divided into two focus groups were interviewed, and a phenomenological hermeneutical design was used. Four interpretations closely related to each other were revealed: it is essential to have an understanding of the patients' transition history; the nurse' repertoire is challenged in the transition process; care must be adapted to the patients' life world; the excellence of care is threatened by the co…