Search results for "lanicemine"

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Hyperforin Potentiates Antidepressant-Like Activity of Lanicemine in Mice

2018

International audience; N-methyl-D-aspartate receptor (NMDAR) modulators induce rapid and sustained antidepressant like-activity in rodents through a molecular mechanism of action that involves the activation of Ca2+ dependent signaling pathways. Moreover, ketamine, a global NMDAR antagonist is a potent, novel, and atypical drug that has been successfully used to treat major depressive disorder (MDD). However, because ketamine evokes unwanted side effects, alternative strategies have been developed for the treatment of depression. The objective of the present study was to determine the antidepressant effects of either a single dose of hyperforin or lanicemine vs. their combined effects in m…

0301 basic medicineSynapsin Iketamine[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/NeurobiologyTRPC 6Pharmacologylcsh:RC321-571TRPC6NMDA - receptor03 medical and health sciencesCellular and Molecular Neurosciencechemistry.chemical_compound0302 clinical medicinemedicinehyperforinlcsh:Neurosciences. Biological psychiatry. NeuropsychiatryMolecular BiologyOriginal ResearchBrain-derived neurotrophic factorChemistrylanicemine[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciencesTail suspension test3. Good healthHyperforin030104 developmental biologyMechanism of actionLaniceminedepressionNMDA receptormedicine.symptom030217 neurology & neurosurgeryNeuroscience

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