Search results for "lcsh:B"

Análisis de las características de estabilidad emocional en hombres y mujeres

2017

La investigación previa indica que la estabilidad emocional, como rasgo de personalidad, tiene una repercusión relevante sobre el comportamiento humano. Dicha estabilidad tiene dos dimensiones: El “umbral de alteración emocional” (facilidad para experimentar estados emocionales alterados) y la “resiliencia emocional” (la capacidad para recuperarse de las emociones negativas y volver a la estabilidad emocional). El objetivo de este estudio consiste en analizar las diferencias entre hombres y mujeres en cuanto a sus niveles de estabilidad emocional, teniendo en cuenta ambas dimensiones. La muestra está formada por 134 estudiantes universitarios de edades comprendidas entre 18 y 40 años. Los r…

The 2D:4D ratio and its relationship with other androgenisation parameters in parents of individuals with autism spectrum disorders.

2013

The 2D:4D ratio is the quotient between the index and ring fin-ger lengths and is a non-direct indicator of androgenisation. If prenatal tes-tosterone levels in the amniotic fluid are high then the probability increases of developing lower ratio values. It has been suggested that people with au-tism spectrum disorders (ASD) and their parents may have highly andro-genised brains, and for this reason the 2D:4D ratio is used as a marker of such idiosyncrasies. This study aims to analyse if parents of people with ASD differ from the general population in several parameters of andro-genisation related to the 2D:4D ratio. The sample was composed of 43 parents of offspring with ASD and 42 controls…

The Crisis on the Labor Market in Romania

2007

In the last 17 years the labor market in Romania has suffered deep changes. We can found two distinct stages regarding the evolutions on the labor market in Romania after 1989. The first stage, which includes the period 1990 – 2003, is defined as a period of deep restructurations of the Romanian economy. It is characterized as a period of relatively high unemployment and the undertaken actions were directed mainly at limiting the unemployment and its harmful effects on the society. We consider that after 2005 the employment evolution heads towards a new crisis on the labor market, but its cause is not a high unemployment, but rather an offer dropping on the labor market. The causes and the …

On the Choice of the Extracellular Vesicles for Therapeutic Purposes

2019

Extracellular vesicles (EVs) are lipid membrane vesicles released by all human cells and are widely recognized to be involved in many cellular processes, both in physiological and pathological conditions. They are mediators of cell-cell communication, at both paracrine and systemic levels, and therefore they are active players in cell differentiation, tissue homeostasis, and organ remodeling. Due to their ability to serve as a cargo for proteins, lipids, and nucleic acids, which often reflects the cellular source, they should be considered the future of the natural nanodelivery of bio-compounds. To date, natural nanovesicles, such as exosomes, have been shown to represent a source of diseas…

Heat Shock Protein 60 in Hepatocellular Carcinoma: Insights and Perspectives

2020

Heat shock protein 60 (HSP60) is a mitochondrial chaperone that is implicated in physiological and pathological processes. For instance, it contributes to protein folding and stability, translocation of mitochondrial proteins, and apoptosis. Variations in the expression levels of HSP60 have been correlated to various diseases and cancers, including hepatocellular carcinoma (HCC). Unlike other HSPs which clearly increase in some cancers, data about HSP60 levels in HCC are controversial and difficult to interpret. In the current review, we summarize and simplify the current knowledge about the role of HSP60 in HCC. In addition, we highlight the possibility of its targeting, using chemical com…

Protein tyrosine nitration and thiol oxidation by peroxynitrite-strategies to prevent these oxidative modifications.

2013

The reaction product of nitric oxide and superoxide, peroxynitrite, is a potent biological oxidant. The most important oxidative protein modifications described for peroxynitrite are cysteine-thiol oxidation and tyrosine nitration. We have previously demonstrated that intrinsic heme-thiolate (P450)-dependent enzymatic catalysis increases the nitration of tyrosine 430 in prostacyclin synthase and results in loss of activity which contributes to endothelial dysfunction. We here report the sensitive peroxynitrite-dependent nitration of an over-expressed and partially purified human prostacyclin synthase (3.3 μM) with an EC50 value of 5 μM. Microsomal thiols in these preparations effectively co…

Tiedelehden kehittämisestä ja työelämän tutkimuksesta

2019

Response-To-Intervention in Finland and the United States: Mathematics Learning Support as an Example

2018

Response to Intervention (RTI) was accepted in the early 2000s as a new framework for identifying learning difficulties (LD) in the U.S. In Finland, a similar multi-tiered framework has existed since 2010. In the present study, these frameworks are presented from the viewpoint of the role of assessment and instruction as expressed in documents that describe the frameworks, as it seems that these two components of RTI are the most disparate between the U.S. and Finland. We present a suggestion for the Finnish framework as an example of support in mathematics learning that incorporates principles of RTI (such as systematized assessment and instruction, cyclic support, and modifiable instructi…

New is not always costly: evidence from online processing of topic and contrast in Japanese.

2013

Two visual ERP experiments were conducted to investigate topic and contrast assigned by various cues such as discourse context, sentential position and marker during referential processing in Japanese. Experiment 1 showed that there was no N400-difference for new vs. given noun phrases (NPs) when the new NP was expected (contrastively focused) based on its preceding context and sentential position. Experiment 2 further revealed that the N400 for new NPs can be modulated by the NP’s contrastive meaning (exhausitivity) induced from the marker. Both experiments also showed that new NPs engendered an increased Late Positivity. The reduced N400 for new vs. given supports an expectation-based lin…

Open Service Innovation: The Case of Tourism Firms in Scandinavia

2016

Most empirical research investigating open innovation has focused on the development of new physical products in manufacturing industries, whereas open service innovation has not been researched correspondingly. Services have some characteristics that distinguish them from physical products, which may affect the types of open innovation practice utilised during service innovation processes. Tourism services comprise a subset of services that is particularly distant from tangible products. Therefore, the exploration of how tourism firms utilise different types of open innovation practice offers a valuable opportunity to learn about the nature of open service innovation practices. Thus, this …