Search results for "lege"
showing 10 items of 265 documents
Partial Stabilization of Input-Output Contact Systems on a Legendre Submanifold
2017
This technical note addresses the structure preserving stabilization by output feedback of conservative input-output contact systems, a class of input-output Hamiltonian systems defined on contact manifolds. In the first instance, achievable contact forms in closed-loop and the associated Legendre submanifolds are analysed. In the second instance the stability properties of a hyperbolic equilibrium point of a strict contact vector field are analysed and it is shown that the stable and unstable manifolds are Legendre submanifolds. In the third instance the consequences for the design of stable structure preserving output feedback are derived: in closed-loop one may achieve stability only rel…
2,3-Dihydrobenzofuran privileged structures as new bioinspired lead compounds for the design of mPGES-1 inhibitors
2016
International audience; 2,3-Dihydrobenzofurans are proposed as privileged structures and used as chemical platform to design small compound libraries. By combining molecular docking calculations and experimental verification of biochemical interference, we selected some potential inhibitors of microsomal prostaglandin E2 synthase (mPGES)-1. Starting from low affinity natural product 1, by our combined approach we identified the compounds 19 and 20 with biological activity in the low micromolar range. Our data suggest that the 2,3-dihydrobenzofuran derivatives might be suitable bioinspired lead compounds for development of new generation mPGES-1 inhibitors with increased affinity.
Human limbal fibroblast-like stem cells induce immune-tolerance in autoreactive T lymphocytes from female patients with Hashimoto’s thyroiditis
2017
Background Due to their “natural immune privilege” and immunoregulatory properties human fibroblast-like limbal stem cells (f-LSCs) have acquired great interest as a potential tool for achieving immunotolerance. Hashimoto’s thyroiditis (HT) is the most common thyroid autoimmune disease and cause of hypothyroidism. To date, conventional hormone replacement therapy and unspecific immunosuppressive regimens cannot provide a definitive cure for HT subjects. We explored the immunosuppressant potential of human f-LSCs on circulating lymphomonocytes (PBMCs) collected from healthy donors and female HT patients. Methods We assessed the immunophenotyping of f-LSCs, both untreated and after 48 h of pr…
Time for a “Plan B” in Peritoneal Metastatic Disease
2019
Abstract Peritoneal involvement in cancer is the harbinger of a particularly unfavorable prognosis. The peritoneal cavity microenvironment is skewed toward immunoregulatory conditions promoted by macrophage populations and innate-like B-1 B cells, which provide immune privilege to malignant cell foci. In this issue of Cancer Research, Haro and colleagues demonstrate that triggering innate IgM-mediated B-1a immune responses via pathogen- or danger-associated molecular pattern recognition exerts antitumor effects on peritoneal metastases by inducing classical complement cascade activation. Exploitation of innate B-1 humoral responses and noncellular immunity is a promising strategy to counter…
Immunobiology of Uveal Melanoma: State of the Art and Therapeutic Targets
2019
Uveal Melanoma (UM) represents the most common primary intraocular malignant tumor in adults. Although it originates from melanocytes as cutaneous melanoma, it shows significant clinical and biological differences with the latter, including high resistance to immune therapy. Indeed, UM can evade immune surveillance via multiple mechanisms, such as the expression of inhibitory checkpoints (e.g., PD-L1, CD47, CD200) and the production of IDO-1 and soluble FasL, among others. More in-depth understanding of these mechanisms will suggest potential targets for the design of novel and more effective management strategies for UM patients.
Meningeal γδ T cell-derived IL-17 controls synaptic plasticity and short-term memory
2019
The notion of "immune privilege" of the brain has been revised to accommodate its infiltration, at steady state, by immune cells that participate in normal neurophysiology. However, the immune mechanisms that regulate learning and memory remain poorly understood. Here, we show that noninflammatory interleukin-17 (IL-17) derived from a previously unknown fetal-derived meningeal-resident γδ T cell subset promotes cognition. When tested in classical spatial learning paradigms, mice lacking γδ T cells or IL-17 displayed deficient short-term memory while retaining long-term memory. The plasticity of glutamatergic synapses was reduced in the absence of IL-17, resulting in impaired long-term poten…
Galerías de «mujeres ilustres» o el sinuoso camino de la excepción a la norma cotidiana (ss. XV-XVIII).
2000
Between the fifteenth and the eighteenth centuries, collections of «illustrious women» were a very widely spread genre all over Europe. Humanistic and courtly in their origins, they were linked to the discourse of women´s «excellence» and they transmitted the values of privilege and aristocratic ethics. At the same time, they showed ambivalent, disturbing and powerful images of «women on top». The fact that its popularity seems to have increased during the eighteenth century and that they took more widespread forms such as articles in the periodicals raises interesting questions about the meanings those images, opposed in many ways to Enlightenment values and attitudes, could have for eight…
Structure of Arabic Scale of Death Anxiety With Chinese College Students: A Bifactor Approach
2018
The Arabic Scale of Death Anxiety (ASDA), as one of the most widely used measures of death anxiety (DA), has increasingly been applied in many studies. However, the structures derived from different studies are highly inconsistent. In this study, both traditional and novel (bifactor) modeling approaches were used, to investigate the most optimal structure of the ASDA in a sample of 984 Chinese college students. After a series of comparisons, the results showed that the bifactor model, with a dominant general DA factor and three distinct sub-dimensions, was the most optimal measurement structure, and measurement invariance of this bifactor model between sexes was also confirmed. Based on the…
Looking towards the Future of Language Assessment: Usability of Tablet PCs in Language Testing
2016
[EN] This research addresses the change in how the Spanish University Entrance Examination can be delivered in the future. There is a wide acknowledgement that computer tests are very demanding for the delivering institutions which makes computer language testing difficult to implement. However, the use of tablet PCs can facilitate the delivery at even lower cost than the regular computer based language testing. 183 students in their last year of high school took a computer based language test which included reading, writing, listening and speaking. The research aspects were 1) whether they feel at ease with the tablet PC exam; 2) if they felt that visual aspects were accessible and 3) whet…
Auto-eficácia percebida e desempenho técnico-táticos de taekwondo universidade
2016
Este trabajo analiza el rendimiento deportivo y la autopercep- ción por medio de metodología observacional y el análisis de autoeficacia, respectivamente, según el género y el éxito de los deportistas en taekwon- do. Se presentan dos estudios: el estudio 1, con dos objetivos, pretendió analizar (i) las propiedades psicométricas del Cuestionario de Autoeficacia Percibida en Acciones de Taekwondo (CAPAT) y (ii) la autoeficacia de los taekwondistas según el género y el éxito en combate. El estudio 2 buscó analizar el rendimiento técnico-táctico de los taekwondistas según el géne- ro y el éxito en combate. Los participantes fueron deportistas universitarios (estudio 1, N = 86; estudio 2, N = 85…