Search results for "lethargic"

showing 2 items of 2 documents

Enhanced tonic GABAA inhibition in typical absence epilepsy

2009

The cellular mechanisms underlying typical absence seizures, which characterize various idiopathic generalized epilepsies, are not fully understood, but impaired γ-aminobutyric acid (GABA)-ergic inhibition remains an attractive hypothesis. In contrast, we show here that extrasynaptic GABAA receptor–dependent 'tonic' inhibition is increased in thalamocortical neurons from diverse genetic and pharmacological models of absence seizures. Increased tonic inhibition is due to compromised GABA uptake by the GABA transporter GAT-1 in the genetic models tested, and GAT-1 is crucial in governing seizure genesis. Extrasynaptic GABAA receptors are a requirement for seizures in two of the best character…

GABA Plasma Membrane Transport ProteinsGABA Plasma Membrane Transport ProteinsCellular pathologystargazerBiologyPharmacologytonic currentSettore BIO/09 - FisiologiaArticleGeneral Biochemistry Genetics and Molecular BiologyTonic (physiology)spike–and–wave discharge03 medical and health sciencesEpilepsy0302 clinical medicineThalamusthalamusGenetic modelmedicineAnimalsGABA transporterGABA-A Receptor AntagonistsReceptorTHIP030304 developmental biology0303 health sciencesextrasynaptic tonic current GAT–1 thalamus spike–and–wave discharge GAERS stargazer lethargic GHB THIPGABAA receptorAminobutyratesPetit mal epilepsyGeneral Medicineextrasynapticmedicine.diseaseReceptors GABA-ARats3. Good healthEpilepsy Absenceabsence epilepsy GABA electrophysiology patch clampnervous systemGAT–1GAERSbiology.proteinlethargicGHB030217 neurology & neurosurgery
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Antiabsence effects of carbenoxolone in two genetic animal models of absence epilepsy (WAG/Rij rats and lh/lh mice).

2005

Carbenoxolone (CBX), the succinyl ester of glycyrrhetinic acid, is an inhibitor of gap junctional intercellular communication. We have tested its possible effects upon two genetic animal models of epilepsy (WAG/Rij rats and lethargic (lh/lh) mice). Systemic administration of CBX was unable to significantly affect the occurrence of absence seizures in WAG/Rij rats. In particular, intravenous (5-40 mg/kg) or intraperitoneal (i.p.; 10-80 mg/kg) administration of CBX was unable to significantly modify the number and duration of spike-wave discharges (SWDs) in WAG/Rij rats, whereas the bilateral microinjection (0.05, 0.1, 0.5 and 1 microg/0.5 microl) of CBX into nucleus reticularis thalami (NRT)…

Malemedicine.medical_specialtyTime FactorsCarbenoxoloneConnexinConnexinsCellular and Molecular Neurosciencechemistry.chemical_compoundEpilepsyMiceMice Neurologic MutantsInternal medicinemedicineAnimalsGlycyrrhizinMicroinjectionGap junctionsPharmacologyDose-Response Relationship DrugGap junctionElectroencephalographyRats Inbred StrainsEpilepsy Carbenoxolone WAG/Rij rat Lethargic mouse Gap junction Connexin Absence seizuresmedicine.diseaseRatsDisease Models AnimalEndocrinologymedicine.anatomical_structurechemistryEpilepsy AbsenceGene Expression RegulationThalamic NucleiSystemic administrationCarbenoxoloneepilepsyAutoradiographyNucleusmedicine.drugGap junctions; Carbenoxolone ; epilepsyNeuropharmacology
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