Search results for "leukocyte"

showing 10 items of 970 documents

Granulocytenfunktionsdefekte bei granulomat�ser muco-cutaner candidiasis

1975

Es wird uber einen 12jahrigen Jungen mit einer rezidivierenden mucocutanen Candidiasis berichtet, der an einer Cryptococcose verstarb. Bei diesem Kind wurden Defekte der unspezifischen Immunitat in Form eines Chemotaxis- und Phagocytosedefizits der polymorphkernigen Neutrophilen nachgewiesen, wahrend Immunglobuline und Komplementfaktoren sowie insbesondere die lymphocytenvermittelten Reaktionen im Normbereich lagen. Die Heterogenitat hinsichtlich der Atiopathogenese der granulomatosen muco-cutanen Candidiasis machen auch Funktionsprufungen der Granulocytenfunktionen erforderlich, zumal solche Defekte inzwischen mehrfach beobachtet wurden.

Polymorphonuclear leukocyteChronic granulomatousbusiness.industryImmunologyMedicineDermatologyGeneral MedicineCutaneous candidiasisbusinessArchives for Dermatological Research
researchProduct

Polymorphonuclear leukocyte
integrin pattern in acute
ischemic stroke

2001

Polymorphonuclear leukocytePathologymedicine.medical_specialtybiologyVascular diseasebusiness.industryIntegrinIschemiaGeneral Medicinemedicine.diseasePathophysiologyCentral nervous system diseaseNeurologymedicinebiology.proteinNeurology (clinical)businessAcute ischemic strokeStrokeActa Neurologica Scandinavica
researchProduct

Polymorphonuclear leukocyte integrin profile in essential hypertension

2000

Polymorphonuclear leukocytebiologybusiness.industryIntegrinImmunologyInternal Medicinemedicinebiology.proteinEssential hypertensionmedicine.diseasebusinessAmerican Journal of Hypertension
researchProduct

Correspondence

1999

Polymorphonuclear leukocytebusiness.industryImmunologyInternal MedicineMembrane fluidityMedicineChemotaxisbusinessEssential hypertensionmedicine.diseaseAmerican Journal of Hypertension
researchProduct

Vascular atherosclerotic disease: Behaviour of the polymorphonuclear leukocyte (PMN) filtration parameters, PMN membrane fluidity and PMN cytosolic C…

1996

Polymorphonuclear leukocytemedicine.medical_specialtyPhysiologyAtherosclerotic diseasechemistry.chemical_elementChemotaxisHematologyCalciumGranulocytePathophysiologyCell biologyCytosolmedicine.anatomical_structureEndocrinologychemistryPhysiology (medical)Internal medicinemedicineMembrane fluidityCardiology and Cardiovascular MedicineClinical Hemorheology and Microcirculation
researchProduct

Effects of forest patch size on physiological stress and immunocompetence in an area-sensitive passerine, the Eurasian treecreeper ( Certhia familiar…

2004

We manipulated the primary brood size of Eurasian treecreepers (Certhia familiaris) breeding in different sized forest patches (0.5-12.8 ha) in moderately fragmented landscapes. We examined the effects of brood size manipulation (reduced, control, enlarged) and forest patch size on physiological stress (heterophil-lymphocyte ratios; H/L), body condition and cell-mediated immunocompetence (phytohaemagglutinin test). Nestlings' H/L ratios were negatively related to forest patch area in control and enlarged broods, whereas no effects were found in reduced broods. The effects of forest patch area were strongest in enlarged broods, which had, in general, twofold higher H/L ratios than control an…

Population DynamicsZoologyEnvironmentPopulation densityGeneral Biochemistry Genetics and Molecular BiologyTreesSongbirdsStress Physiologicalbiology.animalLeukocytesAnimalsPhytohemagglutininsFinlandreproductive and urinary physiologyPhysiological stressGeneral Environmental SciencePopulation DensityGeneral Immunology and MicrobiologybiologyEcologyfungiGeneral MedicineCerthia familiarisbiology.organism_classificationPasserineBroodHabitat destructionLinear Modelsbehavior and behavior mechanismsTreecreeperImmunocompetenceGeneral Agricultural and Biological SciencesResearch ArticleProceedings of the Royal Society of London. Series B: Biological Sciences
researchProduct

CD8+CD45RA+CD27-CD28-T-cell subset in PBL of cervical cancer patients representing CD8+T-cells being able to recognize cervical cancer associated ant…

2003

Objective In response to antigenic stimulation, naive MHC-class I restricted and antigen-specific CD8+CD45RA+CD28+T-cells undergo clonal expansion and differentiate into CD8+CD45RO+ memory T-cells. Upon re- encounter with the nominal antigen, CD45RO+ T-cells are able to convert to CD8+CD45RA+CD28-T-cells displaying potent immune effector functions, including TNF-alpha production. This T-cell subpopulation constitutes a minor population in healthy individuals. In the present study we are currently evaluating whether this particular T-cell subset in PBL represents CD8+T-cells which may be able to recognize cervical cancer associated antigens provided by HPV 16 E7. Material and methods Flow-cy…

PopulationUterine Cervical Neoplasmschemical and pharmacologic phenomenaCD8-Positive T-LymphocytesBiologyEpitopeImmune systemCD28 AntigensAntigenAntigens CDT-Lymphocyte SubsetsmedicineHumansCytotoxic T cellAmino Acid SequenceeducationAntigens ViralPapillomaviridaeNeoplasm Stagingeducation.field_of_studyHistocompatibility TestingObstetrics and GynecologyCD28Cancerhemic and immune systemsmedicine.diseasePeptide FragmentsTumor Necrosis Factor Receptor Superfamily Member 7Lymphatic MetastasisImmunologyCytokinesLeukocyte Common AntigensFemaleCD8Zentralblatt für Gynäkologie
researchProduct

Gene polymorphisms and HLA-G expression in spontaneous abortions

2015

Abstract Introduction HLA-G and HLA-E are claimed to play a role in establishing maternal–fetal immune tolerance and in maintaining pregnancy. The presence of polymorphism in the HLA-G gene could cause a deficient or excessive expression of the HLA-G and HLA-E molecules. These anomalies could eventually cause pregnancy losses. Materials and methods Clinical study. A total of 90 patients were included in this study. These patients suffered spontaneous abortions between weeks 6 and 11 of pregnancy. We have analysed the most important polymorphisms of the HLA-G gene through different genetic studies and HLA-G and HLA-E expression through immunostaining in human cytotrophoblast cells from first…

PregnancyCytotrophoblastKaryotypeHuman leukocyte antigenBiologyAbortionmedicine.diseaseImmune toleranceAndrologymedicine.anatomical_structureHLA-GImmunologymedicineImmunostainingMedicina Reproductiva y Embriología Clínica
researchProduct

HUMAN LEUKOCYTE ANTIGEN POLYMORPHISMS IN ITALIAN PRIMARY BILIARY CIRRHOSIS: A MULTICENTER STUDY OF 664 PATIENTS AND 1992 HEALTHY CONTROLS

2008

Genetic factors are critical in determining susceptibility to primary biliary cirrhosis (PBC), but there has not been a clear association with human leukocyte antigen (HLA) genes. We performed a multicenter case-control study and analyzed HLA class II DRB1 associations using a large cohort of 664 well-defined cases of PBC and 1992 controls of Italian ancestry. Importantly, healthy controls were rigorously matched not only by age and sex, but also for the geographical origin of the proband four grandparents (Northern, Central, and Southern Italy). After correction for multiple testing, DRB1*08 [odds ratio (OR), 3.3; 95% confidence interval (CI), 2.4-4.5] and DRB1*02 (OR 0.9; 95% CI 0.8-1.2) …

ProbandLiver CirrhosisMaleCohort StudiesPrimary biliary cirrhosisGene FrequencyModelsGenotype80 and overMedicineskin and connective tissue diseasesAged 80 and overSettore MED/12 - GastroenterologiaLiver Cirrhosis BiliaryMedicine (all)BiliaryMiddle AgedItalyHLA-DRB1 ChainFemaleCase-Control StudieHumanmusculoskeletal diseasesAdultGenotypeHuman leukocyte antigenArticleGeneticGenetic modelHumansGenetic Predisposition to DiseasePolymorphismAllele frequencyAgedPolymorphism GeneticHepatologyModels Geneticbusiness.industryCase-control studyOdds ratioHLA-DR Antigensmedicine.diseaseHLA-DR AntigenAdult; Aged; Aged 80 and over; Case-Control Studies; Cohort Studies; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; HLA-DR Antigens; Humans; Italy; Liver Cirrhosis Biliary; Male; Middle Aged; Models Genetic; Polymorphism GeneticCase-Control StudiesImmunologyprimary bilairy cirrhosis geneticsCohort StudiebusinessHLA-DRB1 Chains
researchProduct

Characterization of cells with different mitochondrial membrane potential during apoptosis.

2005

Background Until now, the simultaneous analysis of several parameters during apoptosis, including DNA content and mitochondrial membrane potential (ΔΨ), has not been possible because of the spectral characteristics of the commonly used dyes. Using polychromatic flow cytometry based upon multiple laser and UV lamp excitation, we have characterized cells with different ΔΨ during apoptosis. Methods U937 cells were treated with the flavonoid quercetin (Qu) and stained with JC-1 to detect ΔΨ, propidium iodide (PI) for cell viability, Hoechst 33342 for DNA content, Annexin V conjugated with Alexa Fluor-647 for detection of phosphatidilserine (PS) exposure, marker of early apoptosis, or Mitotracke…

Programmed cell deathHistologyCell Membrane PermeabilityCell Survivalpolychromatic flow cytometry • mitochondrial membrane potential • apoptosis • JC-1 • propidium iodide • Hoechst • Annexin-VPopulationApoptosisHL-60 CellsDNA FragmentationPhosphatidylserinesBiologyPathology and Forensic MedicineFlow cytometryMembrane Potentialschemistry.chemical_compoundAnnexinCell Line TumormedicineHumansViability assayPropidium iodideeducationFluorescent Dyeseducation.field_of_studymedicine.diagnostic_testDaunorubicinCell BiologyDNAIntracellular MembranesU937 CellsCarbocyaninesFlow CytometryMolecular biologyMitochondriachemistryApoptosisCell cultureDoxorubicinLeukocytes MononuclearBenzimidazolesQuercetinCytometry. Part A : the journal of the International Society for Analytical Cytology
researchProduct