Search results for "ley"
showing 10 items of 1218 documents
Corporate governance and firm performance: A comparative analysis of auditing problems
2006
The recent financial crises have created a new debate about comparison and convergence of different systems of corporate governance. In particular, they have underlined poor efficiency of rule structures to achieve a good relationship between different stakeholder’s rights. In line with many studies of corporate governance that emphasize the manager-stakeholders relationship as explained by agency theory, in this paper, I analyse the role of auditing as an incentive device to reduce contractual or transaction costs related to asymmetric information.Considering as a benchmark the recent US Sarbanes Oxley Act of July 2002. I describe a set of auditing principles by comparing common and civil …
Approximate Closed-Form Solutions for the Shift Mechanics of Rubber Belt Variators
2009
The mechanical behavior of V-belt variators during the speed ratio shift is different from the steady operation as a gross radial motion of the belt is superimposed to the circumferential motion. The theoretical analysis involves equilibrium equations similar to the steady case, but requires a re-formulation of the mass conservation condition making use of the Reynolds transport theorem. The mathematical model of the belt-pulley coupling implies the repeated numerical solution of a strongly non-linear differential system. Nevertheless, an attentive observation of the numerical diagrams suggests simple and useful closed-form approximations for the four possible working modes of any pulley, o…
Protective Effects of L- and D-Carnosine on R-Crystallin Amyloid Fibril Formation: Implications for Cataract Disease
2009
Mildly denaturing conditions induce bovine ?-crystallin, the major structural lens protein, to self-assemble into fibrillar structures in vitro. The natural dipeptide L-carnosine has been shown to have potential protective and therapeutic significance in many diseases. Carnosine derivatives have been proposed as potent agents for ophthalmic therapies of senile cataracts and diabetic ocular complications. Here we report the inhibitory effect induced by the peptide (L- and D-enantiomeric form) on ?-crystallin fibrillation and the almost complete restoration of the chaperone activity lost after denaturant and/or heat stress. Scanning force microscopy (SFM), thioflavin T, and a turbidimetry ass…
Primary identities in the lower Omo valley: migration, cataclysm, conflict and amalgamation, 1750–1910
2011
This article applies the notion of primary identity to explore the emergence of ethnic identities in the southern-most tract of the lower Omo valley. Current identities here are the result of two correlated patterns of movement that have occurred over the past 150 years: migration to the valley by organised pastoralists and scattered groups, and a general movement down the river and into the Omo delta, where the ecological niche generated by the regular flooding of the Omo River provided a rich variety of livelihood alternatives. The major migrations reported here were connected to great population movements that occurred in East Africa from the nineteenth century, often provoked by catacly…
“C’est la vie, c’est la narration”: The Reader in Christine Brooke-Rose’s Textermination and David Lodge’s Small World
2016
Abstract This article considers two metafictional academic novels from the reader’s point of view. It argues that this critical vantage point is suggested (if not imposed) by the fictional texts themselves. The theoretical texts informing this reading pertain either to reader response or to theories of metafiction, in an attempt to uncover conceptual commonalities between the two. Apart from a thematic focus on academic conferences as pilgrimages and the advocacy of reading as an ethically valuable activity, the two novels also share a propensity for intertextuality, a blurring of the boundaries between fictional and critical discourse, as well as a questioning of the borderline between fic…
“Never Some Easy Flashback”
2012
Abstract This paper provides a close reading of Paul Farley’s 160-line poem, “Thorns.” The poem is read in dialogue with William Wordsworth’s celebrated Romantic ballad “The Thorn.” Special attention is given to Farley’s treatment of memory and metaphor: It is shown how the first, exploratory part of the poem elaborates upon the interdependent nature of memory and metaphor, while the second part uses a more regulated form of imagery in its evocation of a generational memory linked to a particular place and time (the working-class Liverpool of the 1960s and 1970s). The tension between the two parts of the poem is reflected in the taut relationship between the poet and a confrontational alter…
Oppressive Faces of Whiteness in Walter Mosley’s Devil in a Blue Dress
2018
Walter Mosley’s Devil in a Blue Dress contributes significantly to the literary debate on the definition of whiteness. The socio-historical construction of whiteness emerging from the novel is amplified by white imagery dovetailing with the claims made about white people directly. For the African American first person narrator, Easy Rawlins, living in post-World War II Los Angeles, whiteness mostly spells terror. The oppressive faces of whiteness consist in the following trajectories: property relations, economic exploitation, labour relations, the legal system, different miens of oppressive white masculinity denigrating blackness, spatial dynamics of post-World War II Los Angeles and the w…
Depression : The differing Narratives of Couples in Couple Therapy
2014
Introduction When a person becomes depressed, partnership can either be a source of strength, advancing recovery, or a source of further suffering, harming the health of both partners (Cordova & Gee, 2001). Also, depression in one spouse can create feelings of helplessness and hopelessness in both spouses (Cordova & Gee). These are some of the reasons why couple therapy has been used with persons diagnosed with depression and their spouses. Yet, according to Denton and Burwell's (2006) experience, which is similar to our own, the spouses of depressed patients often are not part of the treatment in psychiatric outpatient care, and hence feel unsupported, uninformed, isolated, confused, and f…
Inhibition of Mitochondrial Function by Efavirenz Increases Lipid Content in Hepatic Cells
2010
Efavirenz (EFV) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) widely used in human immunodeficiency virus (HIV) infection therapy. It has been associated with hepatotoxic effects and alterations in lipid and body fat composition. Given the importance of the liver in lipid regulation, we have evaluated the effects of clinically used concentrations of EFV on the mitochondria and lipid metabolism of human hepatic cells in vitro. Mitochondrial function was rapidly undermined by EFV to an extent that varied with the concentration employed; in particular, respiration and intracellular adenosine triphosphate (ATP) levels were reduced whereas reactive oxygen species (ROS) production i…
Efavirenz induces interactions between leucocytes and endothelium through the activation of Mac-1 and gp150,95
2013
The potential cardiovascular (CV) toxicity associated with combined antiretroviral therapy (cART) has been attributed mainly to the nucleoside reverse transcriptase inhibitors abacavir and didanosine. However, the other two components of cART--non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs)--may also be implicated, either directly or by influencing the action of the other drugs. This study evaluates the acute direct effects of the NNRTIs efavirenz and nevirapine and one of the most widely employed PIs, lopinavir, on leucocyte-endothelium interactions, a hallmark of CV disease.Drugs were analysed in vitro in human cells (interactions of peripheral blood…