Search results for "liberation"

Controlling the semi-permeability of protein nanocapsules influences the cellular response to macromolecular payloads.

2021

Nanocapsules are an excellent platform for the delivery of macromolecular payloads such as proteins, nucleic acids or polyprodrugs, since they can both protect the sensitive cargo and target its delivery to the desired site of action. However, the release of macromolecules from nanocapsules remains a challenge due to their restricted diffusion through the nanoshell compared to small molecule cargo. Here, we designed degradable protein nanocapsules with varying crosslinking densities of the nanoshell to control the release of model macromolecules. While the crosslinking did not influence the degradability of the capsules by natural proteases, it significantly affected the release profiles. F…

Polyanion–tobramycin nanocomplexes into functional microparticles for the treatment of Pseudomonas aeruginosa infections in cystic fibrosis

2016

Aim: Efficacy of antibiotics in cystic fibrosis (CF) is compromised by the poor penetration through mucus barrier. This work proposes a new ‘nano-into-micro’ approach, used to obtain a combinatorial effect: achieve a sustained delivery of tobramycin and overcome mucus barrier. Methods: Mannitol microparticles (MPs) were loaded with a tobramycin polymeric nanocomplex and characterized in presence of CF artificial mucus. Results & discussion: MPs are able to alter the rheological properties of CF artificial mucus, enhancing drug penetration into it and allowing a prolonged drug release. MPs resulted to be effective in Pseudomonas aeruginosa infections if compared with free tobramycin. Co…

Interactions texture-flaveur : mécanismes physico-chimiques ou mécanismes cognitifs ? Application à un gel laitier onctueux

2006

Texture, taste and aroma are key components of the perceived quality of foodstuffs. Many studies showed that modifying one of thèse dimensions could modify the perception of another one. However it is not always clear whether thèse interactions could be attributed to physico-chemical or cognitive mechanisms. The présent work aimed at studying sensory interactions between texture, taste and aroma, in relation with the perception of creaminess, an indicator of food quality. A first step consisted in defining the creaminess concept using sensory and verbal approaches. This study highlighted three groups of consumers: creaminess was associated to texture for the first group, to texture and tast…

Foreword

2018

International Bioethics Committees: Conditions for a Good Deliberation

2016

One of the most relevant effects of bioethics emergence has been the spread of deliberative bodies on bioethics matters. Their features are very wide, depending upon the entity that creates them, their regional scope, the issues they deal with, the ruling strength of their agreements, etc. Among them, international bioethics committees are particularly relevant due to the huge impact of their work on global public opinion, as well as on the policies approved by governments all around the world. These bodies are presumed to adopt their decisions, as well as the other bioethics committees, after deliberating on facts and values (Gracia 2001).

Moran on Self-Knowledge, Agency and Responsibility

2006

SUMMARY : In this paper I deal with Richard Moran’s account of self-knowledgein his book Authority and Estrangement . After presenting the main lines of hisaccount, I contend that, in spite of its novelty and interest, it may have someshortcomings. Concerning beliefs formed through deliberation, the account wouldseem to face problems of circularity or regress. And it looks also wanting concerningbeliefs not formed in this way. I go on to suggest a diagnosis of these problems,according to which they would arise out of a view of agents too strongly dependenton the will. KEY WORDS : first person, belief, deliberation, avowals RESUMEN : Este trabajo se ocupa de la concepcion del autoconocimiento…

Researching teachers' and parents' perceptions of dialogue

2013

While there has been a great deal of research done on parent involvement and the challenges of conducting effective dialogue in parent–teacher meetings, less attention has been paid to how teachers and parents themselves perceive dialogue. The purpose of the present article is to study whether deliberative principles are vital to teachers' and parents' perceptions of dialogue. The study seeks to answer this question by initiating qualitative interviews with teachers and parents. The findings show that deliberative principles are definitively vital to the participants' perceptions of dialogue. They include basic deliberation values and procedural aspects of deliberation. However, it must be …

Agamennone βουληφόρος? La sovranità alla prova del processo deliberativo

2022

Starting with the Iliad, Agamemnon is mostly depicted at the centre of dramatic deliberative situations. This feature is also present in fifth-century literature, particularly in some plays in which Agamemnon’s decision-making ability in uncertainty comes into tension with other characters in order to determine the ‘right’ decision and adequate leadership features. In this paper, I will focus on the Euripides’ play Iphigenia in Aulis (405 a.C.). In this tragedy the behaviour of the Achaean king draws our attention, as he is not equipped to handle his role and responsibilities. In the same years, also historiography is interested in the nature and risks of the deliberative process, as Thucyd…

Recensione a: La teologia islamica della liberazione, Hasan Hanafi, a cura di Massimo Campanini

2018

Review of Hasan Hanafi's volume: The Islamic Theology of Liberation, edited by Massimo Campanini

Introduction: A Topographical Approach to Deliberative Democracy

2018

Started as an attempt to move beyond the models of democracy which dominated public and academic discourses during les trente glorieuses (i.e. procedural, aggregative and participatory models of democracy), the deliberative turn seems to have be the opening of several other inner turnings which have help build up a complex theoretical spaghetti junction. Following the main deliberative turn we can also count an 'epistemic turn' (Jörke 2010), and 'empirical turn' (Thompson 2008), a 'systemic turn' (Mansbridge et. al. 2012) and even a 'democratic turn' (Barker et. al. 2012). The end result of these twists and turns is a plurality of models of deliberative democracy (DD) embodying many of the …