Search results for "lidR"
showing 10 items of 24 documents
An intraoral drug delivery device for long term therapies: application in Alzheimer’s disease
2009
A new intraoral device to home assist Parkinson’s disease patients by distant control
2009
Exposing the structure of an Arctic food web
2015
15 pages; International audience; How food webs are structured has major implications for their stability and dynamics. While poorly studied to date, arctic food webs are commonly assumed to be simple in structure, with few links per species. If this is the case, then different parts of the web may be weakly connected to each other, with populations and species united by only a low number of links. We provide the first highly resolved description of trophic link structure for a large part of a high-arctic food web. For this purpose, we apply a combination of recent techniques to describing the links between three predator guilds (insectivorous birds, spiders, and lepidopteran parasitoids) a…
When the seasons don't fit: Speedy molt as a routine carry-over cost of reproduction
2013
The failure of animals to fit all life-cycle stages into an annual cycle could reduce the chances of successful breeding. In some cases, non-optimal strategies will be adopted in order to maintain the life-cycle within the scope of one year. We studied trade-offs made by a High Arctic migrant shorebird, the red knot Calidris canutus islandica, between reproduction and wing feather molt carried out in the non-breeding period in the Dutch Wadden Sea. We compared primary molt duration between birds undertaking the full migratory and breeding schedule with birds that forego breeding because they are young or are maintained in captivity. Molt duration was ca. 71 days in breeding adults, which wa…
Ambulante Therapie & Telemonitoring von Patienten mit Parkinson
2011
Körpernahe Sensornetzwerke können schon heute zur Steigerung der Lebensqualität beitragen, indem der Patient sein gewohntes Umfeld nicht zwingend verlassen muss. Der natürliche und nächste Schritt zur Verbesserung dieser wertvollen Diagnosesysteme beruht auf die Einbeziehung körpernaher Aktuatoren, welche auch eine gleichzeitige Therapierung erlauben. Durch einen interdisziplinären Ansatz, der klinische und technologische Erkenntnisse vereint, entsteht ein Sen-sor- und Aktuatornetzwerk, das am Beispiel eines sich in Entwicklung befindlichen innovativen Systems zur Behandlung von Parkinson vorgestellt wird.
Bioavailability in vivo of naltrexone following transbuccal administration by an electronically-controlled intraoral device: a trial on pigs.
2010
Naltrexone (NLX), an opioid antagonist, is widely used in the treatment of opiate addiction, alcoholism and smoking cessation. Its current peroral administration induces various adverse side effects and has limited efficacy since bioavailability and patient compliance are poor. The development of a long-acting drug delivery system of NLX may overcome the current drawbacks and help in the improvement of treatment of addiction. The primary endpoints of this study were: a) to compare the NLX bioavailability and pharmacokinetics after delivering a single transbuccal dose, released by a prototype of intraoral device, versus an intravenous (I.V.) bolus of the same drug dose; b) to verify the func…
Mechanism of action of Rhodiola, salidroside, tyrosol and triandrin in isolated neuroglial cells: An interactive pathway analysis of the downstream e…
2014
Abstract Aim The aim of this study was to identify the targets (genes, interactive signaling pathways, and molecular networks) of Rhodiola rosea extract in isolated neuroglia cells and to predict the effects of Rhodiola extract on cellular functions and diseases. In addition, the potential mechanism of action of Rhodiola rosea extract was elucidated, and the “active principle” among the three isolated constituents (salidroside, triandrin, and tyrosol) was identified. Methods Gene expression profiling was performed using the T98G human neuroglia cell line after treatment with the Rhodiola rosea SHR-5 extract and several of its individual constituents (salidroside, triandrin and tyrosol). An …
Synergy and Antagonism of Active Constituents of ADAPT-232 on Transcriptional Level of Metabolic Regulation of Isolated Neuroglial Cells
2013
Gene expression profiling was performed on the human neuroglial cell line T98G after treatment with adaptogen ADAPT-232 and its constituents - extracts of Eleutherococcus senticosus root, Schisandra chinensis berry, and Rhodiola rosea root as well as several constituents individually, namely, eleutheroside E, schizandrin B, salidroside, triandrin, and tyrosol. A common feature for all tested adaptogens was their effect on G-protein-coupled receptor signaling pathways, i.e., cAMP, phospholipase C (PLC), and phosphatidylinositol signal transduction pathways. Adaptogens may reduce the cAMP level in brain cells by down-regulation of adenylate cyclase gene ADC2Y and up-regulation of phosphodiest…
The Home-based Empowered Living for Parkinson's disease patients
2009
NOTE SUI LIMICOLI SVERNANTI NELLE ZONE UMIDE COSTIERE DELLA PROVINCIA DI TRAPANI
2016
Notes on wintering waders in the coastal humid zones of province of Trapani (Sicily). The coastal wetlands of Trapani still are of great national importance for migratory and wintering waders despite the dramatic reduction occurred in the last hundred years. During this research the author carried out surveys in coastal wetlands from Trapani to Mazara del Vallo, in order to estimate qualitative and accurate quantitative values of wintering waders. The census includes four winters, from 2012-13 to 2015-16 and was carried out in the months of December and January. Noteworthy is the wintering for three consecutive years of the Terek Sandpiper Xenus cinereus, the wintering of Oystercatcher Haem…