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showing 10 items of 31271 documents

Cold adaptation drives population genomic divergence in the ecological specialist, Drosophila montana

2020

Funding: UK Natural Environment Research Council (Grant Number(s): NE/L501852/1, NE/P000592/1); Academy of Finland (GrantNumber(s): 267244, 268214, 322980), Ella ja Georg Ehrnroothin Säätiö. Detecting signatures of ecological adaptation in comparative genomics is challenging, but analysing population samples with characterised geographic distributions, such as clinal variation, can help identify genes showing covariation with important ecological variation. Here, we analysed patterns of geographic variation in the cold-adapted species Drosophila montana across phenotypes, genotypes and environmental conditions and tested for signatures of cold adaptation in population genomic divergence. We…

0301 basic medicine0106 biological sciencesCandidate geneEcological selectionQH301 Biology01 natural sciencesGenomeDivergencekylmänkestävyysChill coma recovery timeCCRTD. montanamuuntelu (biologia)sopeutuminen0303 health scienceseducation.field_of_studyGEMontanaEcologyGenomicsgenomiikkageneettinen muunteluCline populationsEnvironmental adaptationpopulaatiogenetiikkaDrosophilaGE Environmental SciencesmahlakärpäsetPopulationQH426 GeneticsBiologyCold tolerance010603 evolutionary biology03 medical and health sciencesQH301GeneticsAnimalseducationQH426Ecology Evolution Behavior and SystematicsCTmin030304 developmental biologyComparative genomicsWhole genome sequencingBayes TheoremDAS030104 developmental biologyGenetics PopulationGenomic divergenceMetagenomicsAdaptation
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A time-varying observer for linear systems with asynchronous discrete-time measurements

2017

International audience; In this paper we propose a time-varying observer for a linear continuous-time plant with asynchronous discrete-time measurements. The proposed observer is contextualized in the hybrid systems framework providing an elegant setting for the proposed solution. In particular some theoretical tools are provided, in terms of LMIs, certifying asymptotic stability of a certain compact set where the estimation error is zero. Moreover the case of asynchronous measurements is considered, i.e. when the measurements are not provided in well defined time instants, but they occur at an arbitrary time in a certain time interval. A design procedure based on the numerical solution of …

0301 basic medicine0209 industrial biotechnologyObserver (quantum physics)Computer scienceLinear system02 engineering and technologyInterval (mathematics)Sampled-data observerdiscrete asynchronous measurement[SPI.AUTO]Engineering Sciences [physics]/Automatic03 medical and health sciences030104 developmental biology020901 industrial engineering & automationSettore ING-INF/04 - AutomaticaExponential stabilityDiscrete time and continuous timeAsynchronous communicationControl theoryHybrid systemhybrid systemlinear systemlinear matrix inequalities
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Corrigendum to “Coffee and tea breaks for liver health” [J Hepatol 67 (2017) 221–223]

2017

0301 basic medicine03 medical and health sciences030104 developmental biology0302 clinical medicineHepatologyTraditional medicinebusiness.industryPublished ErratumMEDLINEMedicine030211 gastroenterology & hepatologybusinessJournal of Hepatology
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Past, present and future of immunology in Mainz.

2016

0301 basic medicine03 medical and health sciences030104 developmental biologyAllergy and ImmunologyGermanyImmunologyMEDLINELibrary scienceHumansBiologyCellular immunology
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Proteome Analysis of Colorectal Cancer Cell Line SW480 Released Extracellular Vesicles

2018

The detection and profiling of disease-specific extracellular vesicles (EVs) from body fluids has been challenging research area during recent years. However, the question – can EVs surface proteins be exploited as a credible tool for early cancer diagnosis – is still not answered. Objective of the current study was to find out whether hypoxia induces differences in protein profiles of EVs released from hypoxic human colorectal cancer cells SW480 (EVHyp) and EVs released from these cells grown in normoxic conditions – EVNorm. Obtained results show differences in EVs surface protein samples. Some protein fragments were found only or mostly in EVHyp surface protein samples. Finding of one or …

0301 basic medicine03 medical and health sciences030104 developmental biologyMechanics of MaterialsChemistryMechanical EngineeringProteomeGeneral Materials ScienceProtein profileColorectal cancer cell lineExtracellular vesiclesMicrovesiclesCell biologyKey Engineering Materials
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A nuclear Xdh phylogenetic analysis of yams (Dioscorea: Dioscoreaceae) congruent with plastid trees reveals a new Neotropical lineage

2018

0301 basic medicine03 medical and health sciences030104 developmental biologybiologyPhylogenetic treeEvolutionary biologyDioscoreaceaeLineage (evolution)DioscoreaPlant SciencePlastidbiology.organism_classificationEcology Evolution Behavior and SystematicsBotanical Journal of the Linnean Society
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Teniasis en una niña española

2017

0301 basic medicine03 medical and health sciences0302 clinical medicineTratamiento farmacologicoHepatologybusiness.industry030231 tropical medicine030106 microbiologyGastroenterologyMEDLINEMedicinebusinessHumanitiesGastroenterología y Hepatología
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Investigation of Isoindolo[2,1-a] quinoxaline-6-imines as Topoisomerase I Inhibitors with Molecular Modeling Methods

2017

Background: Isoindolo[2,1-alpha] quinoxalines constitute an important class of compounds which demonstrated potent antiproliferative activity against different human tumor cell lines and topoisomerase I inhibitors. In particular, their water soluble imine or iminium salts recently synthesized showed potent growth inhibitory effect on NCI-60 tumor cell line panel and biological studies performed on the most active compounds demonstrated that they cause DNA damage via topoisomerase I poisoning. Objective: Herein, we investigate with molecular modeling methods, the common features responsible for topoisomerase I inhibition of the water-soluble isoindolo[2,1-alpha] quinoxalin-6-imines, by compa…

0301 basic medicine030103 biophysicsMolecular modelStereochemistryDNA damageAntineoplastic AgentsIsoindolesTopoisomerase-I InhibitorCrystallography X-RayaromatechinStructure-Activity Relationship03 medical and health scienceschemistry.chemical_compoundQuinoxalinetopotecanantiproliferativeCell Line TumorNeoplasmsQuinoxalinesquinoxalineDrug DiscoveryHumansCell Proliferationbiologypharmacophore modelTopoisomeraseIminiumGeneral MedicineSettore CHIM/08 - Chimica FarmaceuticaMolecular Docking SimulationTopoisomerase IindenoisoquinolineDNA Topoisomerases Type IchemistryDocking (molecular)dockingbiology.proteinMolecular MedicineTopoisomerase I; quinoxaline; antiproliferative; topotecan; aromatechin; indenoisoquinoline; docking; pharmacophore modelIminesTopoisomerase I InhibitorsPharmacophore
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Evaluation of Antibacterial Efficacy of Photodynamic Therapy vs. 2.5% NaOCl against E. faecalis-infected Root Canals Using Real-time PCR Technique

2017

Background Bacteria like E. faecalis can produce intra- and extra-radicular biofilms. Theoretically, the adjustable penetration ability of lasers enables better access to root canal system. Therefore the aim of the present study was to compare the ability of photoactivated laser and 2.5% NaOCl irrigation solution to eliminate E. faecalis from the root canals by real-time PCR technique. Material and methods Sixty extracted human upper central incisors were selected and sterilized in an autoclave. The root canals were infected with E. faecalis (PTCC 1237, Persian Type Culture Collection, Iran) and then incubated for 24 hours. The samples were randomly divided into 3 groups. No intervention wa…

0301 basic medicine030103 biophysicsmedicine.medical_treatmentRoot canalDentistryPhotodynamic therapyAntibacterial efficacyBacterial growthEnterococcus faecalis03 medical and health scienceschemistry.chemical_compound0302 clinical medicinemedicineGeneral DentistrySalinebiologybusiness.industry030206 dentistrybiology.organism_classification:CIENCIAS MÉDICAS [UNESCO]medicine.anatomical_structureReal-time polymerase chain reactionchemistrySodium hypochloriteUNESCO::CIENCIAS MÉDICASbusiness
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Oil-degrading bacteria from a membrane bioreactor (BF-MBR) system for treatment of saline oily waste: Isolation, identification and characterization …

2016

A collection of forty-two (42) strains was obtained during microbiological screening of a Membrane Bioreactor (MBR) system developed for the treatment of saline oily waste originated from marine transportation. The diversity of the bacterial collection was analyzed by amplification and sequencing of the 16S rRNA gene. Taxonomic analysis showed high level of identity with recognized sequences of seven (7) distinct bacterial genera (Alcanivorax, Erythrobacter, Marinobacter, Microbacterium, Muricauda, Rhodococcus and Rheinheimera). The biotechnological potential of the isolates was screened considering an important factor such as the biosurfactant production. In particular fourteen (14) biosur…

0301 basic medicine030106 microbiologyMicrobacteriumOil pollution010501 environmental sciencesMembrane bioreactor01 natural sciencesMicrobiologyMicrobiologyBiomaterials03 medical and health sciencesAlcanivoraxOil-degrading bacteriaAlcanivorax Membrane bioreactor (MBR) system Oil pollution Oil-degrading bacteria Saline oily wasteWaste Management and DisposalMembrane bioreactor (MBR) system0105 earth and related environmental sciencesbiologyMarinobacter16S ribosomal RNAbiology.organism_classificationIsolation (microbiology)Saline oily wasteAlcanivoraxRhodococcusBacteria
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