Search results for "lines"
showing 10 items of 3733 documents
Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity
2011
Normal tissue damage limits the efficacy of anticancer therapy. For anthracyclines, the clinically most relevant adverse effect is cardiotoxicity. The mechanisms involved are poorly understood and putative cardioprotectants are controversially discussed. Here, we show that the lipid-lowering drug lovastatin protects rat H9c2 cardiomyoblasts from doxorubicin in vitro. Protection by lovastatin is related to inhibition of the Ras-homologous GTPase Rac1. It rests on a reduced formation of DNA double-strand breaks, resulting from the inhibition of topoisomerase II by doxorubicin. Doxorubicin transport and reactive oxygen species are not involved. Protection by lovastatin was confirmed in vivo. I…
Yliopistojen tutkintokoulutuksen ja tutkimuksen rahoitus ja tulokset vuosina 2000-2004 ja 2005-2009
2010
Problematyka przejmowania infrastruktury kolejowej przez samorząd terytorialny – przykład województwa dolnośląskiego
2021
Regionalny kolejowy transport pasażerski w ostatnich latach dotknięty był zmianami w kontekście organizacji przewozów. Dotyczy to kwestii zarządzania oraz zasięgu obsługiwanej sieci kolejowej. Zauważalne są tendencje do reaktywacji połączeń oraz tworzenia nowych powiązań komunikacyjnych. Jest to związane zarówno z obsługą aglomeracji miejskich, jak i transportu regionalnego. Proces kreowania nowego układu komunikacji kolejowej oparty może być na reaktywacji nieczynnych tras albo budowie nowych połączeń. Procedura przejmowania niewykorzystywanych linii przez samorząd województwa jest elementem odtwarzania pierwotnego systemu kolejowego. Z jednej strony pozwala to na zachowanie infrastruktury…
Spatial conflicts betweem modernizations of railway lines and natural values A case study of Poznań - Szczecin railway line
2017
One of the most intensive processes in the development of Polish transport infrastructure is currently modernizing main national railway lines. One of them is the railway line between Poznan and Szczecin. During the realization of such projects there occur conflicts in fulfilling different ecosystem functions by landscapes. On the basis of the theory of ecosystem services these conflicts should be solved, and potential projects – optimized. The study evaluates natural values of the areas adjacent to the railway line Poznań - Szczecin within a zone of 250 m, and also identifies areas with varying conflict degrees for the realization of the modernization project. The most important areas of h…
Linie kolejowe w Opolskiem ze szczególnym uwzględnieniem procesów ich modernizacji i likwidacji
2020
Kierunki modernizacji sieci kolejowej
2017
Opracowanie przedstawia kierunki modernizacji sieci kolejowej Polski w latach 2003-2017. Długość sieci kolejowej w kraju ulega zmniejszeniu. Zachodzi proces likwidacji linii i zawieszenia przewozów kolejowych. W kraju modernizowane są główne linie magistralne. Na modernizację składają się: wymiana torów, przebudowa trakcji elektrycznej i wprowadzenie nowoczesnych systemów sterowania ruchem i sygnalizacji (ECTS). Przebudowie ulęgają linie kolejowe o znaczeniu tranzytowym zaliczane do europejskiego układu połączeń kolejowych w ruchu pasażerskim (umowa AGC) i towarowym (umowa AGTC). Projekty modernizacji linii kolejowych są finansowane ze środków europejskich i krajowych. Główne źródła finanso…
Application of selected methods of black box for modelling the settleability process in wastewater treatment plant
2017
The paper described how the results of measurement s of inflow wastewater temperature in the chamber, a degree of external and internal recirculation in the biological-mechanical wastewater treatment plan t (WWTP) in Cedzyna near Kielce, Poland, were used to make predictions of settleability of activated sludge. Three methods,namely: multivariate adaptive regression splines (MARS), random forests (RF) and modified random forests (RF+ SOM) were employed to compute activated sludge settleability. The results of analysis indicate that modified random forests demonstrate the best predictive abilities.
Disrupted Spatial Organization of Cued Exogenous Attention Persists Into Adulthood in Developmental Dyslexia
2021
Purpose: Abnormal exogenous attention orienting and diffused spatial distribution of attention have been associated with reading impairment in children with developmental dyslexia. However, studies in adults have failed to replicate such relationships. The goal of the present study was to address this issue by assessing exogenous visual attention and its peripheral spatial distribution in adults with developmental dyslexia.Methods: We measured response times, accuracy and eye movements of 18 dyslexics and 19 typical readers in a cued discrimination paradigm, in which stimuli were presented at different peripheral eccentricities.Results: Results showed that adults with developmental dyslexia…
Regional studies and political science. The theory of the dual unity of Silesia
2021
This paper concerns the status of regional studies in political science research. Analysing the theory of the dual unity of Silesia presented by the Polish political scientist Józef Kokot, the author attempts to formulate theoretical criteria that make a region an object of interest for political scientists and regional studies, a subdiscipline of political science.
Affect self-regulation through music
2018
The present dissertation focused on musical affect regulation, i.e. on the use of music to self-regulate affective states such as emotions, moods, and energy levels. In publication I, relevant findings from previous research were extracted and the field’s conceptual clarity and precision was assessed. Besides identifying weaknesses in conceptualization and providing recommendations for future studies, publication I found that not all the elements of affect regulation through music have been equally explored by research. Given the gap observed on the study of musical mechanisms underlying affect regulation, publication II placed a special focus on this component and its association with regu…