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showing 10 items of 1973 documents
Type 1 Diabetes and Autoimmune Thyroid Disease—The Genetic Link
2021
Type 1 diabetes (T1D) and autoimmune thyroid disease (AITD) are the most frequent chronic autoimmune diseases worldwide. Several autoimmune endocrine and non-endocrine disorders tend to occur together. T1D and AITD often cluster in individuals and families, seen in the formation of autoimmune polyendocrinopathy (AP). The close relationship between these two diseases is largely explained by sharing a common genetic background. The HLA antigens DQ2 (DQA1*0501-DQB1*0201) and DQ8 (DQA1*0301-DQB1*0302), tightly linked with DR3 and DR4, are the major common genetic predisposition. Moreover, functional single nucleotide polymorphisms (or rare variants) of various genes, such as the cytotoxic T-lym…
Maatilayritysbarometri : tutkimusraportti
2012
Maatilayritysbarometrin 2012 tarkoituksena on herättää keskustelua maaseudusta maatilayritysten toimintaympäristönä ja maatilayritysten tulevaisuuden odotuksista. Barometrin tavoitteena on tuottaa virikkeitä maaseutustrategiseen keskusteluun ja tietoa maaseudun kehittämis- ja ohjelmatyölle. Barometrin teemat voidaan pukea kysymysten muotoon: Millainen on keskisuomalaisten maatilayrittäjien suhde maaseutuun? Miten maatilayrittäjät näkevät Keski-Suomen maaseudun vuonna 2016? Miten maatilayrittäjät arvioivat maatilayrityksen liiketoimintaympäristön tulevaisuuden kehitystä ja tulevaisuuden kehitysnäkymiä? Entä miten he arvioivat toimintaedellytysten parantamista ja liiketoiminnan edellytyksiä K…
Social impacts of biodiversity offsetting: A review
2022
Biodiversity offsetting is the widely studied last step of the mitigation hierarchy. Despite numerous studies and the methodological development completed for biodiversity calculations, the human aspect remains unsolved. Biodiversity conservation is typically governed at national or state levels, but the harm caused to biodiversity as well as people occurs locally. In biodiversity offsetting, biodiversity values can be relocated far from the original area, but relocating the values people hold regarding their nearby nature may not be possible. Acknowledging the local people's hopes and values may further complicate biodiversity offsetting, therefore it emphasises even more the need to avoid…
Structure-immunogenicity relationship of kresoxim-methyl regioisomeric haptens
2013
Kresoxim-methyl was one of the two first strobilurins to be discovered, and nowadays it is widely used as an antifungal agent in crop protection. Because of its low molecular weight and negligible structural complexity, the generation of antibodies to kresoxim-methyl noticeably requires the preparation of functionalized haptens. In this study, the introduction of a hydrocarbon spacer arm at the aromatic moieties of the target molecule was carried out by a convergent strategy based on the Sonogashira cross-coupling reaction, and functionalized linkers of the same length were also tethered to the aliphatic toxophore group by the O-alkylation reaction. Evaluation of the immune response, in ter…
Bifunktionaalisten reagenssien synteesi, ominaisuudet ja sovellukset
2006
A netnographic study of how professionals perceive personal branding in LinkedIn
2016
Määräaikaiset, lyhyet työsuhteet ja työttömyys leimaavat tänä päivänä monia ammattialoja ja kilpailu avoimista työpaikoista voi olla erittäin kovaa. Lukemattomat eri alojen ammattilaiset kilpailevat usein samoista rajallisista työpaikoista. Tämä yhtälö on lisännyt kiinnostusta joukosta erottumisen keinoihin, kuten henkilöbrändäykseen ja LinkedInin tyylisiin sosiaalista mediaa hyödyntäviin palve-luihin, jotka voivat toimia työkaluina muista erottumisessa. Tässä maisterintutkielmassa tarkastellaan LinkedIniä käyttävien ammattilaisten käsityksiä henkilö-brändäyksestä LinkedIn-palvelussa. Tutkimuksessa pyritään valottamaan niitä käsityksiä, joita eri alojen ammattilaisilla on LinkedInin käyttäm…
Saistvārdu lietojums emuāros par komercdarbību
2019
Saistvārdi ir svarīgas savienošanas ierīces, kas veicina ideju loģisku sakārtošanu tekstos un rindkopās, un emuāros par komrcdarbību saskaņotības saglabāšana ir tikpat svarīga kā jebkuros citos tekstos. Darba mērķis ir izanalizēt saistvārdu lietošanu piecu visvērtīgāko 2018. gada zīmolu (Amazon, Apple, Google, Microsoft un Facebook) rakstos un ierakstos par komercdarbību. Lai sasniegtu šo mērķi, kā pētniecības metode tika izvēlēta diskursa analīze. Saistvārdi tika noteikti un analizēti, un analīzes rezultāti liecina, ka emuāros par komercdarbību visbiežāk sastopamā saistvārdu kategorija ir pievienošanas / salīdzināšanas kategorija, un visbiežāk izmantotais saist vārds ir arī.
Improving IEEE 802.11 Performance in Chain Topologies through Distributed Polling and Network Coding
2009
Wireless multi-hop networks often rely on the use of IEEE 802.11 technology. Despite of the robustness of the IEEE 802.11 Distributed Coordination Function (DCF) for working in various network scenarios, it has been proven that critical inefficiencies can arise in the case of multi-hop packet forwarding. In this paper, we propose a MAC scheme, based on the virtualization of the Point Coordination Function, optimized for working on chain topologies with bidirectional traffic flows. Our scheme is based on a token-like access mechanism coupled with network coding. The basic idea is the use of multiple Point Coordinators (PCs) along the node chain, which are elected by passing special token fra…
Application Layer FEC for Mobile TV Delivery in IP Datacast Over DVB-H Systems
2009
In this paper we investigate the potential gain that can be obtained in DVB-H using application layer forward error correction (AL-FEC) to perform a multi-burst protection of the transmission for improving the reception of streaming services for mobile terminals. Compared to the conventional approach with link layer multi protocol encapsulation FEC (MPE-FEC), this technique allows to increase the robustness of the DVB-H transmission not only as a function of the capacity devoted for error repair (FEC overhead), but also as a function of the number of bursts jointly encoded. The main drawback of this approach is an increase of the network latency, that can be translated into a larger service…
Optoelectronic Module with Integrated Transceiver and Mux-Demux for Optical Interconnect Applications
2019
The design, development and improvtableement in electronic devices and components have led to the further miniaturization of the system devices and their interconnecting interfaces. Hence, reducing the size of the transmitter (Tx) chips, receiver (Rx) chips and associated components play an important role in designing a reduced/small sized optoelectronic modules for optical interconnect applications. Some of the associated components include multiplexer, demultiplexer, clock and data recovery circuits (CDR), etc. Therefore, in this paper we present an optoelectronic module with integrated transceiver (Tx-Rx) and multiplexer-demultiplexer (mux-demux) with the aim of reducing the total area o…