Search results for "lipidi"

LIPIDOMICA DELL’EPATITE CRONICA DA HCV E DELLA NAFLD. ASSOCIAZIONE TRA ACIDI GRASSI E SFINGOLIPIDI EPATICI CON IL DANNO D’ORGANO

2012

Unvolvement of calcium signaling and MAP kinases in lipid taste perception

2013

In this work, we demonstrate that stromal interaction molecule 1 (STIM1), a sensor of Ca2+ depletion in the endoplasmic reticulum, mediates fatty acid–induced Ca2+ signaling in the mouse tongue and fat preference. We showed that linoleic acid (LA) induced the production of arachidonic acid (AA) and lysophosphatidylcholine (Lyso-PC) by activating multiple phospholipase A2 isoforms via CD36. This activation triggered Ca2+ influx in lingual CD36-positive taste bud cells (TBCs) purified from mouse CVP. LA also induced the production of Ca2+ influx factor (CIF). STIM1 was found to regulate LA-induced CIF production and the opening of store-operated Ca2+ (SOC) channels. Furthermore, CD36-positive…

Modulation of the Biological Activity of a Tobacco LTP1 by Lipid Complexation

2004

Plant lipid transfer proteins (LTPs) are small, cysteine-rich proteins secreted into the extracellular space. They belong to the pathogenesis-related proteins (PR-14) family and are believed to be involved in several physiological processes including plant disease resistance, although their precise biological function is still unknown. Here, we show that a recombinant tobacco LTP1 is able to load fatty acids and jasmonic acid. This LTP1 binds to specific plasma membrane sites, previously characterized as elicitin receptors, and is shown to be involved in the activation of plant defense. The biological properties of this LTP1 were compared with those of LTP1-linolenic and LTP1-jasmonic acid…

A lipocentric view of peptide-induced pores

2010

Although lipid membranes serve as effective sealing barriers for the passage of most polar solutes, nonmediated leakage is not completely improbable. A high activation energy normally keeps unassisted bilayer permeation at a very low frequency, but lipids are able to self-organize as pores even in peptide-free and protein-free membranes. The probability of leakage phenomena increases under conditions such as phase coexistence, external stress or perturbation associated to binding of nonlipidic molecules. Here, we argue that pore formation can be viewed as an intrinsic property of lipid bilayers, with strong similarities in the structure and mechanism between pores formed with participation …

OSSIDAZIONE LIPIDICA E PROTEICA, STATO ANTIOSSIDANTE TOTALE E METABOLITI STABILI DEL NITROSSIDO IN PAZIENTI CON SINDROME METABOLICA

2012

Aspetti emoreologici nella iperviscosità policitemica e sierica

2015

I fattori strutturali in grado di modificare la viscosità ematica sono la massa cellulare, le frazioni proteiche plasmatiche e la deformabilità del globulo rosso. In base alla presenza di uno di questi fattori si distinguono le diverse condizioni primarie di iperviscosità. Mentre l'iperviscosità policitemica è possibile riscontrarla in molti quadri clinici caratterizzati dall'aumento della massa cellulare (policitemia vera, eritrocitosi, leucocitosi iperleucocitiche, trombocitemia), l'iperviscosità sierica è probabile evidenziarla in quadri clinici diversi quali mieloma, malattia di Waldenstrom, crioglobulinemia, disfibrinogenemie, malattie del connettivo, e l'iperviscosità sclerocitemica è…

Studio delle interrelazioni tra stress ossidativo, gelatinasi e loro inibitori in soggetti con sindrome delle apnee ostruttive nel sonno

2015

The Elovl5 enzyme in breast cancer : regulation of cancer cell proliferation and metastasis

2021

Breast cancer is the most diagnosed cancer and the leading cause of cancer death in women. The 5-year relative survival rate is less than 30% for metastatic breast cancer and metastases account for more than 75% of breast cancer deaths. Fatty acid metabolism is altered in cancer and contributes to tumor progression and metastasis. Here, we were interested in Elongation of very long chain fatty acids protein 5 (Elovl5) which catalyzes the elongation of long-chain fatty acids. We observed that the tumors from patients with a breast cancer had a lower expression of Elovl5 than paired normal breast tissue. However, low expression of Elovl5 is associated with a worse prognosis in breast cancer p…

Physiologic and biologic mechanisms induced in Yarrowia lipolytica in response to physico-chemical modifications of cells environment

2010

Hydrophobe compounds are known as carbon source which could be used by yeast like Yarrowia lipolytica for multi purposes. These compounds may cause disturbance in yeast but also reported as confer some resistance to cells towards environmental stress. Here, we study the role of methyl oleate as carbon source on resistance of Y. lipolytica in response to stress of an amphiphilic compound, -dodecalactone, and to heat shock. Results show that cells grown in oleate are more resistant to these stresses than cells grown in glucose. This work reveals the role of the lipids bodies in cells response to stress and that cells manifest in different ways in response to these stresses. An accumulation o…

Peroxydation des lipides émulsionnés et transfert d'ions fer à l'interface huile / eau stabilisée par des protéines de lait : influence des résidus p…

2010

Iron incorporated into food systems induces oxidation and precipitation. The consequences are a reduced bioavailability and a modification of other food flavor. The iron chelates such as Fe-bisglycinate and Fe-EDTA represent a possibility to avoid side effects, since the iron is protected. The inertety of Fe bisglycinate and NaFe EDTA for lipid peroxidation has been verified in oil-in-water emulsion models stabilized by sodium caseinate or by β lactoglobulin through the following studies: i/ increase of primary and secondary products of oxidation, ii/ change of the properties of the oil/water interface (tension and interfacial rheology), iii/ the stability of the chelate iron (Fe-bisglycina…