Search results for "load"

Procollagen C-Proteinase Enhancer 1 (PCPE-1) is a marker of myocardial fibrosis and impaired cardiac function in a murine model of pressure overload

2021

Abstract(1)AimsProcollagen C-proteinase enhancer 1 (PCPE-1) is an extracellular matrix protein and a major regulator of fibrillar collagen biosynthesis. Previous work has shown that its abundance is often increased in the context of tissue repair and fibrosis. The present study was designed to evaluate its potential as a biomarker of myocardial interstitial fibrosis (MIF), a well-established pathogenic pathway leading to heart failure.(2)Methods and ResultsCardiac fibrosis was induced in rats using an optimized model of chronic pressure overload triggered by angiotensin II and Nω-nitro-L-arginine methyl ester (L-NAME). All treated animals suffered from heart hypertrophy and the increase in …

Inhibition of class I histone deacetylase with an apicidin derivative prevents cardiac hypertrophy and failure

2008

AIMS: Recent studies have demonstrated the importance of chromatin remodelling via histone acetylation/deacetylation for the control of cardiac gene expression. Specific histone deacetylases (HDACs) can, in fact, play a positive or negative role in determining cardiac myocyte (CM) size. Here, we report on the effect on hypertrophy development of three inhibitors (HDACi) of class I HDACs. METHODS AND RESULTS: The compounds were first analysed in vitro by scoring hypertrophy, expression of foetal genes, and apoptosis of neonatal rat CMs stimulated with phenylephrine, an alpha1-adrenergic agonist. This initial screening indicated that a truncated derivative of apicidin with class I HDAC specif…

Beta-receptor desensitization evoked by a multistage ultralong distance exercise in the desert?

2021

Background Few studies addressed to the evolution of cardiac function during a multistage ultra-long duration exercise (MULDE). Methods Serial echocardiographic assessment of cardiac function was performed in male healthy subjects during the 2014 Marathon des Sables before the race (T1), at the second (T2) and fifth (T3) arrival (236 km) then after 48 h recovery. Analysis were performed by 2 sonographers blind for the results of the other and the time of measure. Statistical analysis was performed using ANOVA-RM to compare the evolution of the different parameters. Results Among the 20 athletes, 18 completed the study (mean age 42.4, median 42). RR intervals and (Left ventricular End Diasto…

In vitro cardiac performance in the sub-antarctic notothenioids Eleginops maclovinus (subfamily eleginopinae), Paranotothenia magellanica, and Patago…

1997

There is lack of information concerning species diversification in the Non-Antarctic Nototheniid fish both in relation with their variation in organismal performance and in the morphofunctional characteristics underlying this variation. This work was designed to study in three Sub-Antarctic Nototheniids, Eleginops maclovinus, Patagonotothen tessellata, and Paranotothenia magellanica, cardiocirculatory features that may reflect interspecific differences in organismal performance, which in rum may explain aspects of evolutionary and ecological diversity. Haematocrit values were similar in all three species (between 28 and 3?), being in the range of that observed in other red-blooded Nototheni…

Catchment size and contribution of the largest daily events to suspended sediment load on a continental scale

2013

Abstract The classic approach defines an extreme event as a rare event identified by magnitude–frequency analysis and quantified by its deviation from a central value. They are key to understand geomorphological dynamics, since they are responsible for a considerable amount of work and “time compression”. Time compression means that most of the geomorphic work (particularly sediment transport) is produced in very short temporal intervals (i.e. in few events). Moreover, it is well known from magnitude–frequency analyses that events not necessarily extreme by magnitude could be responsible for a large amount of geomorphic work. To analyse the time compression of geomorphological processes, a …

Enantioselective Synthesis of Functionalized Diazaspirocycles from 4‐Benzylideneisoxazol‐5(4H)‐one Derivatives and Isocyanoacetate Esters

2020

Enantioenriched spirocyclic compounds bearing three contiguous stereocenters and high functionalization were obtained through a formal [3+2] cycloaddition reaction catalyzed by a cooperative system. The spiro compounds were synthesized from 4-arylideneisoxazol-5-ones and isocyanoacetate esters using a bifunctional squaramide/Brønsted base organocatalyst derived from a Cinchona alkaloid and silver oxide as Lewis acid. This method afforded two out of the four possible diastereomers with good yields and high enantiomeric excess for both diastereomers.

Changes in Natriuretic Peptides, Cytokines, Selectins and Adhesion Molecules Plasma Levels in Patients with Heart Failure, After Treatment with High …

2007

Mesoporous SBA-15 silica modified with cerium oxide: Effect of ceria loading on support modification

2010

Abstract The present work investigates the effect of ceria loading on silica SBA-15. Five CeO2/SBA-15 samples with CeO2 content equal to 5, 10, 15, 20 and 30 wt% were prepared by wetness-impregnation of the support with cerium nitrate hexahydrate, as precursor, dissolved in ethanol. After drying at room temperature, the resulting samples were calcined at 400 °C for 2h. Characterizations by BET surface area and pore-size distribution, XRD, NH3-TPD and H2-TPR were performed.

Overview of the JET results

2015

Since the installation of an ITER-like wall, the JET programme has focused on the consolidation of ITER design choices and the preparation for ITER operation, with a specific emphasis given to the bulk tungsten melt experiment, which has been crucial for the final decision on the material choice for the day-one tungsten divertor in ITER. Integrated scenarios have been progressed with the re-establishment of long-pulse, high-confinement H-modes by optimizing the magnetic configuration and the use of ICRH to avoid tungsten impurity accumulation. Stationary discharges with detached divertor conditions and small edge localized modes have been demonstrated by nitrogen seeding. The differences in…

1,3-Dipolar cycloaddition of diaryldiazomethanes across N-ethoxy-carbonyl-N-(2,2,2-trichloroethylidene)amine and reactivity of the resulting 2-azabut…

2016

Abstract 1,3-dipolar cycloaddition of diaryldiazomethanes Ar2C N2 across Cl3C–CH N–CO2Et 1 yields Δ3-1,2,4-triazolines 2. Thermolysis of 2 leads, via transient azomethine ylides 3, to diaryldichloroazabutadienes [Ar(Ar')C N–CH CCl2] 4. Treatment of 4a (Ar = Ar' = C6H5) and 4c (Ar = Ar' = p-ClC6H4) with NaSR in DMF yields 2-azabutadienes [Ar2C N–C(H) C(SR)2] 5. In contrast, nucleophilic attack of NaStBu on 4 affords azadienic dithioethers [Ar2C N–C(StBu) C(H)(StBu)] (7a Ar = C6H5; 7b Ar' = p-ClC6H4). The reaction of 4a with NaSEt conducted in neat EtSH produces [Ph2C N–C(H)(SEt)–CCl2H] 8, which after dehydrochloration by NaOMe and subsequent addition of NaSEt is converted to [Ph2C N–C(SEt) C…