Search results for "load"
showing 10 items of 1967 documents
Loading profile of topotecan into polyvinyl alcohol microspheres (DC Bead™) over a 7-day period
2011
Purpose: DC Bead™ is successfully used for chemoembolization of various liver cancers. The purpose of this study was todetermine the loading capacity of the semi-synthetic topoisomerase-1 inhibitor topotecan into the DC Bead™ microspheres under static or agitated conditions and to assess the physicochemical stability over a period of 7 days. Methods: Commercially available topotecan hydrochloride powder (Hycamtin®) was reconstituted with water for injection to yield a nominal concentration of 1 mg/mL topotecan. Polyvinyl alcohol (PVA)-based microspheres (DC Bead™, 300–500 µm, 2 mL/vial) were mixed with 4 mL of the reconstituted topotecan solution. Vials were stored light protected at room …
Coalition: Advocacy for prospective clinical trials to test the post-exposure potential of hydroxychloroquine against COVID-19
2020
Our coalition of public health experts, doctors, and scientists worldwide want to draw attention to the need for high-quality evaluation protocols of the potential beneficial effect of hydroxychloroquine (HCQ) as a post-exposure drug for exposed people. In the absence of an approved, recognized effective pre or post-exposure prophylactic drug or vaccine for COVID-19, nor of any approved and validated therapeutic drug, coupled with social and political pressure raised by publicity both regarding the potential beneficial effect of hydroxychloroquine (HCQ) as well as potential risks from HCQ, we urge the immediate proper clinical trials. Specifically, we mean using HCQ for post-exposure of peo…
Learning about Dynamic Problems with Computer Simulators: A Case of System Dynamics Simulation Models
2008
A vast body of research shows that people by and large fail to understand and manage dynamic environments. Given the increasing complexity of our world, there is an urgent need to develop more effective ways to present dynamic problems. Many studies propose computer simulators as virtual learning environments to help people understand and manage complex problems. Still, experimental data show that simulators often carry problems from reality into the virtual laboratory. An analysis from the perspective of cognitive load theory suggests that learning about complex problems could be improved by enhancing descriptions with simulation elements that would facilitate interactive exploration of th…
Swing options in commodity markets: a multidimensional Lévy diffusion model
2013
Author's version of an article in the journal: Mathematical Methods of Operations Research. Also available from the publisher at: http://dx.doi.org/10.1007/s00186-013-0452-7 We study valuation of swing options on commodity markets when the commodity prices are driven by multiple factors. The factors are modeled as diffusion processes driven by a multidimensional Lévy process. We set up a valuation model in terms of a dynamic programming problem where the option can be exercised continuously in time. Here, the number of swing rights is given by a total volume constraint. We analyze some general properties of the model and study the solution by analyzing the associated HJB-equation. Furthermo…
A distributed dynamic load balancer and its implementation on multi-transputer systems for molecular dynamics simulation
1990
Abstract A new and efficient approach is described to the dynamic load-balancing problem which is central in concurrent computing. A transputer-based implementation is tested on a molecular dynamics simulation of spinodal phase separation.
On the Non-Intrusive Load Monitoring in dwellings: a feasibility perspective
2021
The oncoming modernization process of the power grids, driven above all by decarbonisation objectives and the continuous improvement of digital technologies, is encouraging active participation in the electricity market by consumers through the Demand-Response mechanism. From this perspective, the introduction of smart meters and energy consumption monitoring devices plays a fundamental role, being able to give benefits to consumers, suppliers and the electricity grid itself. This paper proposes a supervised method of non-intrusive load monitoring (NILM) based on the recognition of patterns in the time domain with the Dynamic Time Warping algorithm which is suitable for low-cost smart meter…
Do You See What I See? Effectiveness of 360-Degree vs. 2D Video Ads Using a Neuroscience Approach
2021
[EN] This study compares cognitive and emotional responses to 360-degree vs. static (2D) videos in terms of visual attention, brand recognition, engagement of the prefrontal cortex, and emotions. Hypotheses are proposed based on the interactivity literature, cognitive overload, advertising response model and motivation, opportunity, and ability theoretical frameworks, and tested using neurophysiological tools: electroencephalography, eye-tracking, electrodermal activity, and facial coding. The results revealed that gaze view depends on ad content, visual attention paid being lower in 360-degree FMCG ads than in 2D ads. Brand logo recognition is lower in 360-degree ads than in 2D video ads. …
Within-host evolution decreases virulence in an opportunistic bacterial pathogen
2015
Abstract Background Pathogens evolve in a close antagonistic relationship with their hosts. The conventional theory proposes that evolution of virulence is highly dependent on the efficiency of direct host-to-host transmission. Many opportunistic pathogens, however, are not strictly dependent on the hosts due to their ability to reproduce in the free-living environment. Therefore it is likely that conflicting selection pressures for growth and survival outside versus within the host, rather than transmission potential, shape the evolution of virulence in opportunists. We tested the role of within-host selection in evolution of virulence by letting a pathogen Serratia marcescens db11 sequent…
Dynamic scheduling of periodic skippable tasks in an overloaded real-time system
2008
International audience; The need for supporting dynamic real-time environments where changes in workloads may occur requires a scheduling framework that explicitly addresses overload conditions, allows the system to achieve graceful degradation and supports a mechanism capable of determining the load to be shed from the system to handle the overload. In applications ranging from video reception to air-craft control, tasks enter periodically and have response time constraints, but missing a deadline is acceptable, provided most deadlines are met. Such tasks are said to be occasionally skippable and have an assigned skip parameter. We look at the problem of uniprocessor scheduling of skippabl…
Age-related operator deficits in a realistic instrument-control task: Assessment of possssible motor, cognitive and mental causes
2017
Abstract With advancing age, motor and mental functions gradually change. As these changes have been revealed by standardized laboratory tests, it remains unclear how much they affect older persons' performance in industrial workplace tasks. The present study therefore compared young and older participants in a task modeled after a complex, realistic industrial workplace scenario, and additionally assessed motor, cognitive and mental variables that might have an impact on overall task efficiency. 25 participants (13 young, mean age 25 years; 12 older participants, mean age 65 years) sat in front of a panel with multiple displays - indicating the momentary state of a simulated nuclear power …