Search results for "loop"
showing 10 items of 608 documents
Performance evaluation of fuzzy-neural HTTP request distribution for Web clusters
2006
In this paper we present the performance evaluation of our fuzzy-neural HTTP request distribution algorithm called FNRD, which assigns each incoming request to the server in the Web cluster with the quickest expected response time. The fuzzy mechanism is used to estimate the expected response times. A neural-based feedback loop is used for real-time tuning of response time estimates. To evaluate the system, we have developed a detailed simulation and workload model using CSIM19 package. Our simulations show that FNRD can be more effective than its competitors.
CEND1 and NEUROGENIN2 Reprogram Mouse Astrocytes and Embryonic Fibroblasts to Induced Neural Precursors and Differentiated Neurons
2015
Summary Recent studies demonstrate that astroglia from non-neurogenic brain regions can be reprogrammed into functional neurons through forced expression of neurogenic factors. Here we explored the effect of CEND1 and NEUROG2 on reprogramming of mouse cortical astrocytes and embryonic fibroblasts. Forced expression of CEND1, NEUROG2, or both resulted in acquisition of induced neuronal cells expressing subtype-specific markers, while long-term live-cell imaging highlighted the existence of two different modes of neuronal trans-differentiation. Of note, a subpopulation of CEND1 and NEUROG2 double-transduced astrocytes formed spheres exhibiting neural stem cell properties. mRNA and protein exp…
The NUPR1/p73 axis contributes to sorafenib resistance in hepatocellular carcinoma
2021
The multikinase inhibitor sorafenib was the first drug approved by the FDA for treating patients with advanced hepatocellular carcinoma (HCC). However, sorafenib resistance remains a major challenge for improving the effectiveness of HCC treatment. Previously, we identified several genes modulated after sorafenib treatment of human HCC cells, including the stress-inducible nuclear protein 1 (NUPR1) gene. Multiple studies have shown that NUPR1 regulates autophagy, apoptosis, and chemoresistance. Here, we demonstrate that treatment of HCC cells with sorafenib resulted in the activation of autophagic flux. NUPR1 knock-down (KD) in HCC cells was associated with increased p62 expression, suggest…
Stepwise synthesis and selective dimerisation of bis- and trisloop tetra-urea calix[4]arenes.
2008
Tetra-urea calix[4]arenes substituted with four mono- or bisalkenyl residues have been converted into bis- or tetraloop compounds by intramolecular olefin metathesis, with use of a tetratosylurea calix[4]arene as template. The same strategy has now been used to synthesise trisloop compounds and bisloop compounds with adjacent loops, completing the series of the loop-containing tetra-urea derivatives. A tetra-urea calix[4]arene of the AABB type, where A stands for a bisalkenyl- and B for a monoalkenyl-substituted urea unit, was used as precursor for the three loops. It was easily synthesised from a tetraamino calix[4]arene in which two adjacent amino groups were Boc-protected. The ABCB-type …
Random walk networks
2004
Abstract Random Boolean networks are among the best-known systems used to model genetic networks. They show an on–off dynamics and it is easy to obtain analytical results with them. Unfortunately very few genes are strictly on–off switched. On the other hand, continuous methods are in principle more suitable to capture the real behavior of the genome, but have difficulties when trying to obtain analytical results. In this work, we introduce a new model of random discrete network: random walk networks, where the state of each gene is changed by small discrete variations, being thus a natural bridge between discrete and continuous models.
On the thermomechanical behavior of the European target assembly design of IFMIF-EVEDA lithium test loop under start-up transient scenarios
2013
Uncoupled thermomechanical transient analyses have been carried out to investigate the behavior of IFMIF-EVEDA lithium test loop bayonet backplate target assembly under two selected start-up transient operational scenarios. The first transient scenario considered foresees that the target assembly, starting from the initial uniform temperature of 50 C, is heated up uniquely by convective heat transfer with lithium, flowing from inlet to outlet nozzle at its reference nominal temperature and pressure, until its nominal steady state thermal field distribution is reached. The second transient scenario foresees, more realistically, that the target assembly, starting from the uniform temperature …
Study of the thermo-mechanical performances of the IFMIF-EVEDA Lithium Test Loop target assembly
2012
Abstract Within the framework of the IFMIF R&D program and in close cooperation with ENEA-Brasimone, at the Department of Energy of the University of Palermo a research campaign has been launched to investigate the thermo-mechanical behavior of the target assembly under both steady state and start-up transient conditions. A theoretical approach based on the finite element method (FEM) has been followed and a well-known commercial code has been adopted. A realistic 3D FEM model of the target assembly has been set-up and optimized by running a mesh independency analysis. A proper set of loads and boundary conditions, mainly concerned with radiation heat transfer between the target assembly ex…
Steiner Loops of Affine Type
2020
Steiner loops of affine type are associated to arbitrary Steiner triple systems. They behave to elementary abelian 3-groups as arbitrary Steiner Triple Systems behave to affine geometries over GF(3). We investigate algebraic and geometric properties of these loops often in connection to configurations. Steiner loops of affine type, as extensions of normal subloops by factor loops, are studied. We prove that the multiplication group of every Steiner loop of affine type with n elements is contained in the alternating group An and we give conditions for those loops having An as their multiplication groups (and hence for the loops being simple).
ChemInform Abstract: Multiple Catenanes Based on Tetraloop Derivatives of Calix[4]arenes.
2009
Topologically Novel Multiple Rotaxanes and Catenanes Based on Tetraurea Calix[4]arenes
2006
Calix[4]arenes bearing at their wide rim four urea residues easily form hydrogen bonded dimeric capsules. This has been used to preorganise alkenyl functions attached to these urea groups for their controlled connection via metathesis reaction. Multimacrocyclic tetraurea derivatives are thus obtained in excellent yields via heterodimers which are formed exclusively with tetratosylurea derivatives. Heterodimerisation of such bis- and tetraloop tetraureas leads analogously to multicatenanes, or to rotaxanes by stoppering. Huge macrocycles are detached from tetraloop derivatives by cleavage of the urea function.