Search results for "lp(a)"

Selective uptake and degradation of c-Fos and v-Fos by rat liver lysosomes

1996

AbstractThe transcription factor c-Fos is a short-lived protein and calpains and ubiquitin-dependent systems have been proposed to be involved in its degradation. In this report, we consider a lysosomal degradation pathway for c-Fos. Using a cell-free assay, we have found that freshly isolated lysosomes can take up and degrade c-Fos with high efficiency. v-Fos, the oncogenic counterpart of c-Fos, can also be taken up by lysosomes, yet the amount of incorporated protein is much lower. c-Fos uptake is independent of its phosphorylation state but it appears to be regulated by dimerization with differentially phosphorylated forms of c-Jun, while v-Fos escapes this regulation. Moreover, we show …

Is reproduction really costly? Energy metabolism of bank vole (Clethrionomys glareolus) females through the reproductive cycle

2007

Energetic requirements during reproduction are important determinants of the onset of reproduction and of breeding strategy (e.g., breeding post-partum) and therefore affect female reproductive output in seasonally varying environments. To balance the energetic needs of breeding with energy availability, females must optimize energy allocation between their own energy use and energy allocated to their litter. Here, we studied energetic costs and potential energetic trade-offs of reproduction in female bank voles (Clethrionomys glareolus). We measured energy consumption, i.e., metabolic rates as determined from carbon dioxide production of females either with their pups (breeding unit) to fi…

Crystal Structures and Cytotoxicity of ent-Kaurane-Type Diterpenoids from Two Aspilia Species

2018

A phytochemical investigation of the roots of Aspilia pluriseta led to the isolation of ent-kaurane-type diterpenoids and additional phytochemicals (1⁻23). The structures of the isolated compounds were elucidated based on Nuclear Magnetic Resonance (NMR) spectroscopic and mass spectrometric analyses. The absolute configurations of seven of the ent-kaurane-type diterpenoids (3⁻6, 6b, 7 and 8) were determined by single crystal X-ray diffraction studies. Eleven of the compounds were also isolated from the roots and the aerial parts of Aspilia mossambicensis. The literature NMR assignments for compounds 1 and 5 were revised. In a cytotoxicity assay, 12α-methoxy-ent-kaur-9(11),1…

In vitro evaluation of the temperature increment at the external root surface after Er,Cr:YSGG laser irradiation of the root canal

2009

Objectives. A study was made to determine the temperature increment at the dental root surface following Er,Cr:YSGG laser irradiation of the root canal. Design. Human canines and incisors previously instrumented to K file number ISO 30 were used. Irradiation was carried out with glass fiber endodontic tips measuring 200 µm in diameter and especially designed for insertion in the root canal. The teeth were irradiated at 1 and 2 W for 30 seconds, without water spraying or air, and applying a continuous circular movement (approximately 2 mm/sec.) in the apico-coronal direction. Results. At the 1 W power setting, the mean temperature increment was 3.84ºC versus 5.01ºC at 2 W. In all cases the d…

Iekštelpu putekļu paraugu ņemšanas veidi metālisko elementu noteikšanai

2022

Iekštelpu putekļu paraugu ņemšanas veidi metālisko elementu noteikšanai. Vancoviča, E., zinātniskais vadītājs Dr. Chem. Osīte A. M. Maģistra darbs, 46 lpp, 12 attēli, 11 tabulas, 51 literatūras avoti, 7 pielikumi. Latviešu valodā. Darbā apkopota informācija par smago metālisko elementu analizēšanu un paraugu ievākšanu sedimentētu putekļu paraugos, kā arī gaisa aerosolu daļiņās. Maģistra darba ietvaros ar ICP-MS analizēti elementi Al, V, Cr, Mn, Fe, Ni, Cu, Zn, As, Pb sedimentētu putekļu paraugos, gaisa aerosolu daļiņās PM1, kā arī noteikta metālisko elementu biopieejamība. Paraugi ņemti lielākoties Rīgā un tās tuvējā apkārtnē, izvērtējot metālisko elementu koncentrācijas atkarībā no putekļu…

Analisi di delezioni esoniche del gene PAH in pazienti affetti da iperfenilalaninemia

2009

Fibularis tertius muscle in women & men: A surface anatomy cross-sectional study across countries

2019

The fibularis tertius muscle (FTM) is a rare anatomic variation. The prevalence of this exclusively human structure, which is found in the anterior compartment of the leg, is often underestimated, and it is believed that foot and ankle conditions are more difficult to manage in patients with an FTM. The aim of this study was to assess the presence of the FTM palpation and determine whether its presence is associated with an individual’s sex, because the exact prevalence in males and females is unclear. An observational cross-sectional study was carried out. The study included 481 people (23.49% men and 76.51% women) with a mean age of 23.51±5.369 years, who were recruited from a Podiatric M…

Mesenchymal stem cells derived from inflamed dental pulpal and gingival tissue: a potential application for bone formation

2017

Background Chronic periodontal disease is an infectious disease consisting of prolonged inflammation of the supporting tooth tissue and resulting in bone loss. Guided bone regeneration procedures have become common and safe treatments in dentistry, and in this context dental stem cells would represent the ideal solution as autologous cells. In this study, we verified the ability of dental pulp mesenchymal stem cells (DPSCs) and gingival mesenchymal stem cells (GMSCs) harvested from periodontally affected teeth to produce new mineralized bone tissue in vitro, and compared this to cells from healthy teeth. Methods To characterize DPSCs and GMSCs, we assessed colony-forming assay, immunophenot…

VITOM® 3D in Arterio-Venous Fistulas: Single Centre Preliminary Surgical Experience

2021

Background: Arteriovenous fistula (AVF) is the vascular access of choice for hemodialysis patients. A correct microsurgical vascular anastomoses is essential to the optimal care of patients. Loupes can help surgeons perform such procedures, but often cause neck or back pain and fatigue. Aim: This study aimed to evaluate whether a video telescopic operating microscope (VITOM®; Karl Storz Endoscopy GmbH, Tuttlingen, Germany) could be used as a substitute for loupes to create microsurgical vascular anastomoses. Methods: We evaluated microsurgical anastomoses with VITOM® in 10 patients (6 male, 4 female) from January 2019 to December 2019. The created anastomoses were 7 side-to-side, 2 side-to-…

Psychophysiological responses of junior orienteers under competitive pressure

2018

The purpose of the study was to examine psychobiosocial states, cognitive functions, endocrine responses (i.e., salivary cortisol and chromogranin A), and performance under competitive pressure in orienteering athletes. The study was grounded in the individual zones of optimal functioning (IZOF) and biopsychosocial models. Fourteen junior orienteering athletes (7 girls and 7 boys), ranging in age from 15 to 20 years (M = 16.93, SD = 1.77) took part in a two-day competitive event. To enhance competitive pressure, emphasis was placed on the importance of the competition and race outcome. Psychophysiological and performance data were collected at several points before, during, and after the ra…