Search results for "luukudokset"
showing 6 items of 6 documents
A collagen extraction and deuterium oxide stable isotope tracer method for the quantification of bone collagen synthesis rates in vivo.
2021
Abstract The development of safe and practical strategies to prevent weakening of bone tissue is vital, yet attempts to achieve this have been hindered by a lack of understanding of the short‐term (days‐weeks) physiology of bone collagen turnover. To address this, we have developed a method to quantify bone collagen synthesis in vivo, using deuterium oxide (D2O) tracer incorporation techniques combined with gas chromatography pyrolysis isotope‐ratio mass spectrometry (GC‐pyrolysis‐IRMS). Forty‐six male and female rats from a selectively bred model ingested D2O for 3 weeks. Femur diaphyses (FEM), tibia proximal (T‐PRO), and distal (T‐DIS) epiphyses‐metaphyses and tibia mid‐shaft diaphyses (T…
Bioactive glass ions induce efficient osteogenic differentiation of human adipose stem cells encapsulated in gellan gum and collagen type I hydrogels
2019
Abstract Background Due to unmet need for bone augmentation, our aim was to promote osteogenic differentiation of human adipose stem cells (hASCs) encapsulated in gellan gum (GG) or collagen type I (COL) hydrogels with bioactive glass (experimental glass 2-06 of composition [wt-%]: Na2O 12.1, K2O 14.0, CaO 19.8, P2O5 2.5, B2O3 1.6, SiO2 50.0) extract based osteogenic medium (BaG OM) for bone construct development. GG hydrogels were crosslinked with spermidine (GG-SPD) or BaG extract (GG-BaG). Methods Mechanical properties of cell-free GG-SPD, GG-BaG, and COL hydrogels were tested in osteogenic medium (OM) or BaG OM at 0, 14, and 21 d. Hydrogel embedded hASCs were cultured in OM or BaG OM fo…
Kovatehoisen, iskutyyppisen harjoittelun vaikutukset reisiluun kaulan lujuuteen lievää polven nivelrikkoa sairastavilla postmenopausaali-ikäisillä na…
2013
TIIVISTELMÄ Kovatehoisen, iskutyyppisen harjoittelun vaikutukset reisiluun kaulan lujuuteen lievää polven nivelrikkoa sairastavilla postmenopausaali-ikäisillä naisilla. Satunnaistettu kontrolloitu tutkimus. Janhunen, Eija Fysioterapian Pro Gradu- tutkielma Jyväskylän yliopisto, Liikuntatieteellinen tiedekunta, Terveystieteiden laitos 2013 Sivuja 79 Ohjaajat: Prof. Ari Heinonen ja THM Juhani Multanen, Jyväskylän Yliopisto, Terveystieteiden laitos Tämän satunnaistetun kontrolloidun tutkimuksen tarkoituksena oli tutkia 12 kuukautta kestäneen iskutyyppisen harjoittelun vaikutuksia reisiluun kaulan lujuuteen lievää polven nivelrikkoa sairastavilla postmenopausaali-ikäisillä naisilla. Kahdeksanky…
Biological basis of bone strength : Anatomy, physiology and measurement
2020
Understanding how bones are innately designed, robustly developed and delicately maintained through intricate anatomical features and physiological processes across the lifespan is vital to inform our assessment of normal bone health, and essential to aid our interpretation of adverse clinical outcomes affecting bone through primary or secondary causes. Accordingly this review serves to introduce new researchers and clinicians engaging with bone and mineral metabolism, and provide a contemporary update for established researchers or clinicians. Specifically, we describe the mechanical and non-mechanical functions of the skeleton; its multidimensional and hierarchical anatomy (macroscopic, m…
Characterisation of peripheral bone mineral density in youth at risk of secondary osteoporosis : a preliminary insight
2020
Objectives: To describe peripheral long bone material and structural differences in youth at risk of secondary osteoporosis across disease-specific profiles. Methods: Upper- and lower limbs of children and adolescents were scanned at 4% distal and 66% mid-shaft sites using peripheral Quantitative Computed Tomography sub-categorised as (1) increased risk of secondary osteoporosis (neuromuscular disorders; chronic diseases; endocrine diseases; inborn errors of metabolism; iatrogenic conditions), (2) low motor competence and (3) non-affected controls. Results: Children with disease-specific profiles showed a range of bone deficits compared to the control group with these predominantly indicate…
Bone mineral density, structure, distribution and strength in men with prostate cancer treated with androgen deprivation therapy
2019
Androgen deprivation therapy (ADT) improves survival in men with advanced prostate cancer (PCa), but has been associated with compromised skeletal health and increased fracture risk. However, limited previous research has investigated determinants of bone strength beyond DXA-derived areal bone mineral density (aBMD) in this population group. The aim of this cross-sectional study was to investigate the effects of ADT in men with PCa on BMD, bone structure, estimates of whole bone strength and cortical bone distribution. A total of 70 ADT-treated men, 52 PCa controls and 70 healthy controls had DXA lumbar spine and proximal femur aBMD and pQCT distal (4%) and proximal (66%) tibia and radius c…