Search results for "lähetti-RNA"

showing 3 items of 3 documents

IGF2BP3 Associates with Proliferative Phenotype and Prognostic Features in B-Cell Acute Lymphoblastic Leukemia

2021

Simple Summary Although the prognosis of acute lymphoblastic leukemia (ALL) has improved significantly during the past decades, ALL remains a major cause of pediatric cancer mortality, and more accurate risk-stratification is required. We investigated IGF2BP3, which has previously been associated with aggressive cancers, and found high and subtype-specific expression of IGF2BP3 in B-cell ALL, that was associated with good outcome in high-risk patients. Results suggest that IGF2BP3 could be useful to improve stratification and prognosis of B-ALL. Abstract The oncofetal protein insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) belongs to a family of RNA-binding proteins involved i…

lähetti-RNAmRNAproliferation3122 Cancersleukemiabiomarkkeritennusteetlcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogensinsulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)lcsh:RC254-282Articleinsulin-like growth factor 2 mRNA-binding protein 3 (<i>IGF2BP3</i>)akuutti lymfaattinen leukemiapediatric B-cell acute lymphoblastic leukemia1182 Biochemistry cell and molecular biologysyöpätauditproteiinitprognosisproteinCancers
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Toxicity of biomining effluents to Daphnia magna: Acute toxicity and transcriptomic biomarkers

2018

Increasing metal consumption is driving the introduction of new techniques such as biomining to exploit low grade ores. The biomining impacts notably aquatic ecosystems, yet, the applicability of ecotoxicological tests to study the complex mixture effects of mining waters is insufficiently understood. The aim of the present work was to test if transcriptomic biomarkers are suitable and sensitive for the ecotoxicity assessment of biomining affected waters. The study site had been affected by a multimetal biomine, and the studied water samples formed a concentration gradient of contamination downstream from the biomining site. Cadmium and nickel were used as positive controls in the toxicity …

0301 basic medicinelähetti-RNAHealth Toxicology and Mutagenesis010501 environmental sciences01 natural sciencesNickelmetallitmixture toxicityCadmiumbioliuotusbiologyvesien saastuminenChemistryGeneral MedicineContaminationPollutiontranskriptio (biologia)Environmental chemistryToxicitykaivosvesiCadmiumkaivoksetmining effluentEnvironmental EngineeringmRNAta1172Daphnia magnametalschemistry.chemical_elementBiominingmyrkyllisyysMining03 medical and health sciencesToxicity Tests AcuteAnimalsEnvironmental ChemistryEffluent0105 earth and related environmental sciencesPublic Health Environmental and Occupational HealthGeneral Chemistrybiology.organism_classificationAcute toxicitysub-lethal030104 developmental biologyDaphniaGene Expression RegulationmarkkeritvesikirputbioleachingEcotoxicityTranscriptomeBiomarkersChemosphere
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Toxicity of biomining effluents to Daphnia magna : Acute toxicity and transcriptomic biomarkers

2018

Increasing metal consumption is driving the introduction of new techniques such as biomining to exploit low grade ores. The biomining impacts notably aquatic ecosystems, yet, the applicability of ecotoxicological tests to study the complex mixture effects of mining waters is insufficiently understood. The aim of the present work was to test if transcriptomic biomarkers are suitable and sensitive for the ecotoxicity assessment of biomining affected waters. The study site had been affected by a multimetal biomine, and the studied water samples formed a concentration gradient of contamination downstream from the biomining site. Cadmium and nickel were used as positive controls in the toxicity …

mining effluentkaivoksetbioliuotuslähetti-RNAvesien saastuminenmRNAbiomarkkeritmyrkyllisyyssub-lethaltranskriptio (biologia)vesikirputkaivosvesimetallitmixture toxicity
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