Search results for "m10"
showing 10 items of 118 documents
Tramvaju kustības radīto atmosfēras aerosolu izcelsmes un izplatības novērtējums Rīgā
2021
Bakalaura darbā raksturota atmosfēras piesārņojuma problemātika, īpaša uzmanība pievērsta videi draudzīgākajam satiksmes veidam – tramvaju satiksmei. Tramvaju radītais cieto daļiņu (PM10, PM2,5) atmosfēras piesārņojums analizēts vērtējot dažādus aspektus – ekspluatētais tramvaja modeļa veids, kustības režīms, papildus vērtēta arī meteoroloģisko apstākļu ietekme. Eksperimentālā daļa realizēta Rīgā, veicot tiešos mērījumus laika periodā no 2020. gada rudens līdz 2021.gada pavasarim, tādējādi mērījumi tika veikti 3 dažādās sezonās, dažādos meteoroloģiskajos apstākļos, mainīga novietojuma un noslogotatības maršruta daļās.
Gaisa aerosolu frakciju skaita un sastāva analīze dzelzceļa apkārtnē
2018
Gaisa aerosolu frakciju skaita un sastāva analīze dzelzceļa apkārtnē. Bite I., vadītājs Dr. ķīm., doc. Osīte A. Bakalaura darbs, 31 lappuses, 10 attēli, 10 tabulas, 28 literatūras avoti, 2 pielikumi. Latviešu valodā. Literatūras apskatā veikts aerosolu klasifikācijas izvērtējums pēc to rašanās avotiem, kā arī raksturoti pētījumu rezultāti par dzelzceļa un metro staciju apkārtnē ievāktajiem aerosoliem un to ietekmi uz cilvēku organismu. Eksperimentālajā daļā veikta gaisa aerosolu frakciju PM10 un PM2.5, kā arī ultrasmalko aerosolu daļiņu masas un skaita koncentrāciju analīze dzelzceļa stacijas Torņakalns tuvumā. Paraugi ievākti, izmantojot aerosolu spektrometru, dihotomo impaktoru, mobilu ae…
Regulation of the alpha-secretase ADAM10 by its prodomain and proprotein convertases.
2001
SPECIFIC AIMSTo identify the proprotein convertases responsible for maturation of the α-secretase ADAM10, we investigated the influence of PC7 and furin on ADAM10 processing and the resulting effect on amyloid precursor protein cleavage. We also examined the functional role of the ADAM10 prodomain by coexpression of a prodomain-deleted ADAM10 mutant together with its prodomain in trans.PRINCIPAL FINDINGS1. ADAM10 is proteolytically processed by PC7 and furinThe disintegrin metalloproteinase ADAM10 possesses α-secretase activity as well as a potential proprotein convertase recognition sequence (RKKR) after its prodomain. By amino-terminal sequencing of ADAM10 purified from bovine kidney plas…
Extracting Conditionally Heteroskedastic Components using Independent Component Analysis
2020
In the independent component model, the multivariate data are assumed to be a mixture of mutually independent latent components. The independent component analysis (ICA) then aims at estimating these latent components. In this article, we study an ICA method which combines the use of linear and quadratic autocorrelations to enable efficient estimation of various kinds of stationary time series. Statistical properties of the estimator are studied by finding its limiting distribution under general conditions, and the asymptotic variances are derived in the case of ARMA-GARCH model. We use the asymptotic results and a finite sample simulation study to compare different choices of a weight coef…
The effects of α-secretase ADAM10 on the proteolysis of neuregulin-1
2009
Although ADAM10 is a major alpha-secretase involved in non-amyloidogenic processing of the amyloid precursor protein, several additional substrates have been identified, most of them in vitro. Thus, therapeutical approaches for the prevention of Alzheimer's disease by upregulation of this metalloproteinase may have severe side effects. In the present study, we examined whether the ErbB receptor ligand neuregulin-1, which is essential for myelination and other important neuronal functions, is cleaved by ADAM10. Studies with beta- and gamma-secretase inhibitors, as well as with the metalloproteinase inhibitor GM6001, revealed an inhibition of neuregulin-1 processing in human astroglioma cell …
Alpha-secretase activation--an approach to Alzheimer's disease therapy.
2006
The nonamyloidogenic pathway of processing the amyloid precursor protein (APP) involves the cleavage within the amyloid-beta peptide sequence, and thus precludes amyloid-beta formation. The identification of a member of the disintegrin and metalloproteinase family, ADAM10, as an alpha-secretase that prevents plaque formation and hippocampal deficits in vivo gave us the possibility to examine the alpha-secretase as a potential target for the therapy of Alzheimer's disease. Within the priority program Cellular Mechanisms of Alzheimer's Disease, we investigated several approaches to stimulate the alpha-secretase pathway. Two protein convertases were found to be responsible for the removal of t…
The Role of the anti-amyloidogenic secretase ADAM10 in shedding the APP-like proteins.
2011
ADAM10 (A disintegrin and metalloproteinase 10) has been demonstrated as an enzyme with protective properties in Alzheimer's disease: in mouse models it not only lowered generation of toxic A-beta peptides and formation of senile plaques but also alleviated learning deficits and enhanced synaptic density. This is due to cleavage of the amyloid precursor protein (APP) within its A-beta stretch and to the release of the extracellular domain of APP with neuroprotective function. Aside from cleaving APP, ADAM10 has been linked to over 40 putative substrates at least in cell culture. These substrates are connected with important cellular functions such as cell migration, stress response and tran…
Atmosfēras piesārņojuma personificētais monitorings
2020
Bakalaura darbā “Atmosfēras piesārņojuma personificētais monitorings” apkopota zinātniskā literatūra par atmosfēras piesārņojumu, avotiem, ietekmi uz veselību, raksturota situācija Latvijā. Darba praktiskā daļā veikti cieto daļiņu (PM10, PM2,5), slāpekļa dioksīda un gaistošo organisko savienojumu mērījumi dažādos selektīvi izvēlētos maršrutos laika periodā no 20.02.2020. līdz 29.04.2020. realizējot personificēto monitoringu. Mērījumi veikti izmantojot ar gaisa kvalitātes sensoriem aprīkotu iekārtu – individuālo dozimetru. Iegūtie mērījumi sistematizēti un apstrādāti, lai novērtētu indivīdam uzņemto piesārņojuma dozu.
Receptor for advanced glycation end products is subjected to protein ectodomain shedding by metalloproteinases.
2008
The receptor for advanced glycation end products (RAGE) is a 55-kDa type I membrane glycoprotein of the immunoglobulin superfamily. Ligand-induced up-regulation of RAGE is involved in various pathophysiological processes, including late diabetic complications and Alzheimer disease. Application of recombinant soluble RAGE has been shown to block RAGE-mediated pathophysiological conditions. After expression of full-length RAGE in HEK cells we identified a 48-kDa soluble RAGE form (sRAGE) in the culture medium. This variant of RAGE is smaller than a 51-kDa soluble version derived from alternative splicing. The release of sRAGE can be induced by the phorbol ester PMA and the calcium ionophore c…
Retinoids as a Perspective in Treatment of Alzheimer’s Disease
2010
<i>Background:</i> In the past, we demonstrated that the disintegrin metalloproteinase ADAM10 has α-secretase activity in vitro and in cultured cells. We also found out that moderate overexpression of this proteinase inhibits Aβ peptide production and prevents the formation of amyloid plaques in an Alzheimer’s disease (AD) mouse model. Moreover, it corrects early hippocampal defects like LTP impairment and increases cortical synaptogenesis. <i>Objective:</i> Upregulation of ADAM10 might be an alternative approach concerning AD therapy. Our current research therefore focuses on substances and/or pathways which regulate ADAM10 gene expression. <i>Methods:</i&g…