Search results for "machine learning."
showing 10 items of 1455 documents
Validation of a Reinforcement Learning Policy for Dosage Optimization of Erythropoietin
2007
This paper deals with the validation of a Reinforcement Learning (RL) policy for dosage optimization of Erythropoietin (EPO). This policy was obtained using data from patients in a haemodialysis program during the year 2005. The goal of this policy was to maintain patients' Haemoglobin (Hb) level between 11.5 g/dl and 12.5 g/dl. An individual management was needed, as each patient usually presents a different response to the treatment. RL provides an attractive and satisfactory solution, showing that a policy based on RL would be much more successful in achieving the goal of maintaining patients within the desired target of Hb than the policy followed by the hospital so far. In this work, t…
Restricted Neighborhood Search Clustering Revisited: An Evolutionary Computation Perspective
2013
Protein-protein interaction networks have been broadly studied in the last few years, in order to understand the behavior of proteins inside the cell. Proteins interacting with each other often share common biological functions or they participate in the same biological process. Thus, discovering protein complexes made of groups of proteins strictly related, can be useful to predict protein functions. Clustering techniques have been widely employed to detect significative biological complexes. In this paper, we integrate one of the most popular network clustering techniques, namely the Restricted Neighborhood Search Clustering (RNSC), with evolutionary computation. The two cost functions in…
Hidden Markov Random Field model and BFGS algorithm for Brain Image Segmentation
2016
Brain MR images segmentation has attracted a particular focus in medical imaging. The automatic image analysis and interpretation became a necessity. Segmentation is one of the key operations to provide a crucial decision support to physicians. Its goal is to simplify the representation of an image into items meaningful and easier to analyze. Hidden Markov Random Fields (HMRF) provide an elegant way to model the segmentation problem. This model leads to the minimization problem of a function. BFGS (Broyden-Fletcher-Goldfarb-Shanno algorithm) is one of the most powerful methods to solve unconstrained optimization problem. This paper presents how we combine HMRF and BFGS to achieve a good seg…
Intra-cardiac Signatures of Atrial Arrhythmias Identified by Machine Learning and Traditional Features
2021
Intracardiac devices separate atrial arrhythmias (AA) from sinus rhythm (SR) using electrogram (EGM) features such as rate, that are imperfect. We hypothesized that machine learning could improve this classification.
Information Decomposition in Bivariate Systems: Theory and Application to Cardiorespiratory Dynamics
2015
In the framework of information dynamics, the temporal evolution of coupled systems can be studied by decomposing the predictive information about an assigned target system into amounts quantifying the information stored inside the system and the information transferred to it. While information storage and transfer are computed through the known self-entropy (SE) and transfer entropy (TE), an alternative decomposition evidences the so-called cross entropy (CE) and conditional SE (cSE), quantifying the cross information and internal information of the target system, respectively. This study presents a thorough evaluation of SE, TE, CE and cSE as quantities related to the causal statistical s…
Impact of Wavelet Kernels on Predictive Capability of Radiomic Features: A Case Study on COVID-19 Chest X-ray Images
2023
Radiomic analysis allows for the detection of imaging biomarkers supporting decision-making processes in clinical environments, from diagnosis to prognosis. Frequently, the original set of radiomic features is augmented by considering high-level features, such as wavelet transforms. However, several wavelets families (so called kernels) are able to generate different multi-resolution representations of the original image, and which of them produces more salient images is not yet clear. In this study, an in-depth analysis is performed by comparing different wavelet kernels and by evaluating their impact on predictive capabilities of radiomic models. A dataset composed of 1589 chest X-ray ima…
Evaluation of Hybrid Models to Estimate Chlorophyll and Nitrogen Content of Maize Crops in the Framework of the Future CHIME Mission
2022
In the next few years, the new Copernicus Hyperspectral Imaging Mission (CHIME) is foreseen to be launched by the European Space Agency (ESA). This mission will provide an unprecedented amount of hyperspectral data, enabling new research possibilities within several fields of natural resources, including the “agriculture and food security” domain. In order to efficiently exploit this upcoming hyperspectral data stream, new processing methods and techniques need to be studied and implemented. In this work, the hybrid approach (HYB) and its variant, featuring sampling dimensionality reduction through active learning heuristics (HAL), were applied to CHIME-like data to evaluate the…
The Three Steps of Clustering in the Post-Genomic Era: A Synopsis
2011
Clustering is one of the most well known activities in scientific investigation and the object of research in many disciplines, ranging from Statistics to Computer Science. Following Handl et al., it can be summarized as a three step process: (a) choice of a distance function; (b) choice of a clustering algorithm; (c) choice of a validation method. Although such a purist approach to clustering is hardly seen in many areas of science, genomic data require that level of attention, if inferences made from cluster analysis have to be of some relevance to biomedical research. Unfortunately, the high dimensionality of the data and their noisy nature makes cluster analysis of genomic data particul…
Artificial intelligence in the cyber security environment
2019
Artificial Intelligence (AI) is intelligence exhibited by machines. Any system that perceives its environment and takes actions that maximize its chance of success at some goal may be defined as AI. The family of AI research is rich and varied. For example, cognitive computing is a comprehensive set of capabilities based on technologies such as deep learning, machine learning, natural language processing, reasoning and decision technologies, speech and vision technologies, human interface technologies, semantic technology, dialog and narrative generation, among other technologies. Artificial intelligence and robotics have steadily growing roles in our lives and have the potential to transfo…
An Early Stage Researcher's Primer on Systems Medicine Terminology
2021
Background: Systems Medicine is a novel approach to medicine, that is, an interdisciplinary field that considers the human body as a system, composed of multiple parts and of complex relationships at multiple levels, and further integrated into an environment. Exploring Systems Medicine implies understanding and combining concepts coming from diametral different fields, including medicine, biology, statistics, modeling and simulation, and data science. Such heterogeneity leads to semantic issues, which may slow down implementation and fruitful interaction between these highly diverse fields. Methods: In this review, we collect and explain more than100 terms related to Systems Medicine. Thes…