Search results for "machine"
showing 10 items of 2592 documents
A Statistical Study to Analyze the Impact of External Weather Change on Chronic Pulmonary Infection in South Norway with Machine Learning Algorithms
2021
In this paper, we analyzed the holistic impact of external weather on chronic pulmonary infection in the Agder region with traditional machine learning algorithms. Millions of people are diagnosed with Chronic Obstructive Pulmonary Disease (COPD). Our study is dedicated in the Agder region, the Southern part of Norway. Norway has four seasons – winter (December-February), late winter/spring (March-May), Summer (June-August), and Autumn (September-November) in a year with average annual temperature approx. 7.5 °C | 45.5 °F and an annual rainfall of 1260 mm or 49.6 in. in Kristiansand. As predicted by the World Health Organization (WHO), in 2016, Norway suffered from 8% mortality due to c(1)h…
T Cells Expressing Receptor Recombination/Revision Machinery Are Detected in the Tumor Microenvironment and Expanded in Genomically Over-unstable Mod…
2021
AbstractTumors undergo dynamic immunoediting as part of a process that balances immunologic sensing of emerging neoantigens and evasion from immune responses. Tumor-infiltrating lymphocytes (TIL) comprise heterogeneous subsets of peripheral T cells characterized by diverse functional differentiation states and dependence on T-cell receptor (TCR) specificity gained through recombination events during their development. We hypothesized that within the tumor microenvironment (TME), an antigenic milieu and immunologic interface, tumor-infiltrating peripheral T cells could reexpress key elements of the TCR recombination machinery, namely, Rag1 and Rag2 recombinases and Tdt polymerase, as a poten…
SuperHistopath: A Deep Learning Pipeline for Mapping Tumor Heterogeneity on Low-Resolution Whole-Slide Digital Histopathology Images.
2021
High computational cost associated with digital pathology image analysis approaches is a challenge towards their translation in routine pathology clinic. Here, we propose a computationally efficient framework (SuperHistopath), designed to map global context features reflecting the rich tumor morphological heterogeneity. SuperHistopath efficiently combines i) a segmentation approach using the linear iterative clustering (SLIC) superpixels algorithm applied directly on the whole-slide images at low resolution (5x magnification) to adhere to region boundaries and form homogeneous spatial units at tissue-level, followed by ii) classification of superpixels using a convolution neural network (CN…
Przegląd metod śródoperacyjnej oceny marginesów w chirurgicznym leczeniu oszczędzającym gruczoł piersiowy
2021
Breast conserving therapy is the primary treatment modality in early-stage breast cancer patients. Despite the development of methods for the intraoperative assessment of tumor margins, 20–30% of patients still require re-resection due to postoperative tumor infiltration at the surgery margins. In recent years, many methods have been developed to reduce the number of re-resections due to margin infiltration. Here we review the current methods together with several more techniques under investigation.
Novel Approaches for Glioblastoma Treatment: Focus on Tumor Heterogeneity, Treatment Resistance, and Computational Tools
2019
BACKGROUND: Glioblastoma (GBM) is a highly aggressive primary brain tumor. Currently, the suggested line of action is the surgical resection followed by radiotherapy and treatment with the adjuvant temozolomide (TMZ), a DNA alkylating agent. However, the ability of tumor cells to deeply infiltrate the surrounding tissue makes complete resection quite impossible, and in consequence, the probability of tumor recurrence is high, and the prognosis is not positive. GBM is highly heterogeneous and adapts to treatment in most individuals. Nevertheless, these mechanisms of adaption are unknown. RECENT FINDINGS: In this review, we will discuss the recent discoveries in molecular and cellular heterog…
Comparison of relaxation techniques in virtual reality for breast cancer patients
2019
A number of studies demonstrated that virtual reality (VR) featuring pleasant scenarios and relaxing narratives is effective in promoting relaxation in users, both in healthy and pathological contexts. One important field for application of relaxing VR is breast cancer, because of therapy-related distress and changes in body imagine experienced by patients during the care process. However, comparisons between different relaxation techniques adapted to virtual reality are rare. In the present study, the same virtual environment has been integrated with audio narratives designed according to two different relaxation techniques (respiration control and body scan). As initial exploration, 16 br…
Improving Communication in Risk Management of Health Information Technology Systems by means of Medical Text Simplification
2019
Health Information Technology Systems (HITS) are increasingly used to improve the quality of patient care while reducing costs. These systems have been developed in response to the changing models of care to an ongoing relationship between patient and care team, supported by the use of technology due to the increased instance of chronic disease. However, the use of HITS may increase the risk to patient safety and security. While standards can be used to address and manage these risks, significant communication problems exist between experts working in different departments. These departments operate in silos often leading to communication breakdowns. For example, risk management stakeholder…
Enhanced Modelling for Extended Performance Analysis of Interior Permanent Magnet Synchronous Machine Drive fed with Cascaded H-Bridges Multilevel In…
2021
This paper presents a comparative simulation analysis of an Interior Permanent Magnet Synchronous Machine (IPMSM) performance once fed by a traditional three-phase two-level inverter and then using a three-phase five-level Cascaded H-Bridges Multilevel Inverter (CHBMI). For this purpose, an enhanced mathematical model of the IPMSM, that take into account simultaneously saturation, cross-coupling, spatial harmonics and iron loss effects, has been employed. Furthermore, two different PWM modulation strategies have been considered. The study was conducted for several working conditions, evaluating the impact of CHBMI adoption on the IPMSM performance in terms of improved efficiency and torque …
Case-Sensitivity of Classifiers for WSD: Complex Systems Disambiguate Tough Words Better
2007
We present a novel method for improving disambiguation accuracy by building an optimal ensemble (OE) of systems where we predict the best available system for target word using a priori case factors (e.g. amount of training per sense). We report promising results of a series of best-system prediction tests (best prediction accuracy is 0.92) and show that complex/simple systems disambiguate tough/easy words better. The method provides the following benefits: (1) higher disambiguation accuracy for virtually any base systems (current best OE yields close to 2% accuracy gain over Senseval-3 state of the art) and (2) economical way of building more effective ensembles of all types (e.g. optimal,…
OPETH: Open Source Solution for Real-Time Peri-Event Time Histogram Based on Open Ephys
2019
Single cell electrophysiology remains one of the most widely used approaches of systems neuroscience. Decisions made by the experimenter during electrophysiology recording largely determine recording quality, duration of the project and value of the collected data. Therefore, online feedback aiding these decisions can lower monetary and time investment, and substantially speed up projects as well as allow novel studies otherwise not possible due to prohibitively low throughput. Real-time feedback is especially important in studies that involve optogenetic cell type identification by enabling a systematic search for neurons of interest. However, such tools are scarce and limited to costly co…