Search results for "macula"

Male dominance and immunocompetence in a field cricket

2004

Female preference for dominant males has been found in many species, and it is generally thought that winners of male-male competition are of superior quality. Success in contests probably depends on male condition and overall health. Thus, females could avoid infection and gain genetic benefits in terms of more viable offspring by mating with dominant males. In the present study, we tested whether dominant males of the Mediterranean field cricket, Gryllus bimaculatus, had higher immunocompetence than did their subordinates in experimental trials. We found that dominant males had better immune defense, as indicated by significantly higher encapsulation rate and lytic activity, than did subo…

Infracyanine Green vs. Brilliant Blue G in Inverted Flap Surgery for Large Macular Holes: A Long-Term Swept-Source OCT Analysis

2020

Background and Objectives: To compare the long-term toxicity of infracyanine green (IFCG) to brilliant blue G (BBG) in inverted internal limiting membrane flap surgery (I-ILMFS) for large, full-thickness macular holes (FTMHs). Materials and Methods: Prospective randomized study including 39 eyes with &ge

Treatment of macular oedema (excluding age-related macular degeneration (AMD))

2021

Macular oedema corresponds to an increase in macular thickness most often associated with a rupture of the hematoretinal barriers. Diagnosis is based on the notion of reduced vision, but above all on multimodal imaging in which optical coherence tomography (OCT) plays an essential role both for the initial diagnosis and for follow-up. The mechanisms involved in the occurrence of macular oedema are primarily vascular endothelial growth factor (VEGF) and cytokines regardless of the aetiology of the oedema. Treatment often involves a combination of local treatment - primarily intravitreal injections of anti-VEGF or corticosteroids - and, in certain situations, such as diabetes or uveitis, gene…

Cellular targets in diabetic retinopathy therapy

2021

Despite the existence of treatment for diabetes, inadequate metabolic control triggers the appearance of chronic complications such as diabetic retinopathy. Diabetic retinopathy is considered a multifactorial disease of complex etiology in which oxidative stress and low chronic inflammation play essential roles. Chronic exposure to hyperglycemia triggers a loss of redox balance that is critical for the appearance of neuronal and vascular damage during the development and progression of the disease. Current therapies for the treatment of diabetic retinopathy are used in advanced stages of the disease and are unable to reverse the retinal damage induced by hyperglycemia. The lack of effective…

Retinal Fundus Multi-Disease Image Dataset (RFMiD): A Dataset for Multi-Disease Detection Research

2021

The world faces difficulties in terms of eye care, including treatment, quality of prevention, vision rehabilitation services, and scarcity of trained eye care experts. Early detection and diagnosis of ocular pathologies would enable forestall of visual impairment. One challenge that limits the adoption of computer-aided diagnosis tool by ophthalmologists is the number of sight-threatening rare pathologies, such as central retinal artery occlusion or anterior ischemic optic neuropathy, and others are usually ignored. In the past two decades, many publicly available datasets of color fundus images have been collected with a primary focus on diabetic retinopathy, glaucoma, age-related macular…

Redescription of Tipula octomaculata Savchenko, with notes on related Holarctic species (Diptera, Tipulidae)

2007

Tipula (Pterelachisus) octomaculata Savchenko, 1964 (Diptera, Tipulidae) has hitherto been known only from the type locality in north-western Russia, and no material besides the holotype male has been available for study. In this article we report T. octomaculata for the first time from Finland, redescribe the species and compare its morphological characters with those of related Nearctic species (T. trivittata Say, T. angulata Loew, T. entomophthorae Alexander). The Finnish finding locality in Ks: Taivalkoski, North boreal ecoregion, is briefly discussed.

Intravitreal Aflibercept Injection for Macular Edema Resulting from Central Retinal Vein Occlusion

2014

PURPOSE: To evaluate the efficacy and safety of intravitreal aflibercept injections for treatment of macular edema secondary to central retinal vein occlusion (CRVO). DESIGN: A randomized, multicenter, double-masked phase 3 study. PARTICIPANTS: A total of 177 treatment-naive patients with macular edema secondary to CRVO were randomized in a 3:2 ratio. METHODS: Patients received either 2-mg intravitreal aflibercept or sham injections every 4 weeks for 20 weeks. From week 24 to 48, the aflibercept group received aflibercept as needed (pro re nata [PRN]), and the sham group continued receiving sham injections. MAIN OUTCOME MEASURES: The primary efficacy end point was the proportion of patients…

PERSEUS-IT 24-month analysis: a prospective observational study to assess the effectiveness of intravitreal aflibercept in routine clinical practice …

2022

Abstract Purpose PERSEUS-IT (NCT02289924) was a prospective, observational, 2-year study evaluating the effectiveness and treatment patterns of intravitreal aflibercept (IVT-AFL) in patients with neovascular age-related macular degeneration (nAMD) in routine clinical practice in Italy. Methods Treatment-naïve patients with nAMD receiving IVT-AFL per routine clinical practice were enrolled. The primary endpoint was mean change in visual acuity (VA; decimals) from baseline to month (M) 12 and M24. Outcomes were evaluated for the overall study population and independently for the 2 treatment cohorts: regular (3 initial monthly doses, ≥ 7 injections by M12, and ≥ 4 injections between M12 and M2…

Una Inmaculada localizada en Alicante, obra atribuida al genovés Domenico Piola

2018

Salve glosada.

Com a tít. el que precedeix al text de les p. [2-3 Grav. xil. orlat a la p. [1]: "La Purisima Concepcion, Patrona de España y sus Indias: Por cada Salve rezada con toda devocion, hay concedidos 120. dias de Indulgencia" Grav. xil. orlat a la p. [4]: "El Patriarca San Josef, Patron en la presente Guerra" Sign.: [ ]2 Text de la Salve glosada, p. [2-3] a dues col. separades per filet