Search results for "magnolia"
showing 3 items of 3 documents
Epimagnolin A, a tetrahydrofurofuranoid lignan from Magnolia fargesii, reverses ABCB1-mediated drug resistance.
2018
Abstract Background Epimagnolin A is an ingredient of the Chinese crude drug Shin-i, derived from the dried flower buds of Magnolia fargesii and Magnolia flos, which has been traditionally used for the treatment of allergic rhinitis and nasal congestion, empyema, and sinusitis. The pharmacokinetic activity of epimagnolin A remains to be evaluated. Purpose In this study, we examined the possible interactions of epimagnolin A with human ATP-binding cassette (ABC) transporter ABCB1, a membrane protein vital in regulating the pharmacokinetics of drugs and xenobiotics. Study design/methods The interaction of epimagnolin A with ABCB1 was evaluated in calcein, ATPase, and MTT assays by using Flp-I…
Cytotoxicity of the bisphenolic honokiol from Magnolia officinalis against multiple drug-resistant tumor cells as determined by pharmacogenomics and …
2014
A main problem in oncology is the development of drug-resistance. Some plant-derived lignans are established in cancer therapy, e.g. the semisynthetic epipodophyllotoxins etoposide and teniposide. Their activity is, unfortunately, hampered by the ATP-binding cassette (ABC) efflux transporter, P-glycoprotein. Here, we investigated the bisphenolic honokiol derived from Magnolia officinalis. P-glycoprotein-overexpressing CEM/ADR5000 cells were not cross-resistant to honokiol, but MDA-MB-231 BRCP cells transfected with another ABC-transporter, BCRP, revealed 3-fold resistance. Further drug resistance mechanisms analyzed study was the tumor suppressor TP53 and the epidermal growth factor recepto…
Representatives of the Magnoliaceae juss. family growing upon different climatic conditions from the botanical gardens collections of Taras Shevchenk…
2016
Has been described the phenology of deciduous magnolias growing ex situ in botanical gardens of Acad. O.V Fomin SRC "Institute of Biology" National Taras Shevchenko University of Kyiv and the University and Latvia (Riga). 9 species, 1 variety and 3 hybrids identical for both collections of botanical gardens were selected and used for phenological observations. The studied plants were resistant to winter and summer climatic factors, were marked the parameters that determine their plasticity in less precipitation in Ukraine and Latvia, as compared to the places of their natural habitat, and expanding the use of exotic species in landscaping design of the megapolises.