Search results for "maine"
showing 10 items of 554 documents
Barbegal carbonate imprints give a voice to the first industrial complex of Europe
2019
International audience; The watermill complex of Barbegal is one of the first industrial complexes in the world, and one of the largest such installations known from antiquity. It has been studied through excavations and what is known about the complex, its history and purpose, is based on the remaining stonework of mills and water installations, since no traces of the woodwork or machinery of the mills have been preserved. The archaeological museum in Arles, however, stores 142 pieces of carbonate that formed on the woodwork of the mills. We studied this material by analysis of the shape of the fragments and of stable isotopes and crystallographic fabric of selected carbonate samples. This…
Introducing the Human Factor in Predictive Modelling: a Work in Progress
2012
International audience; In this paper we present the results of a study into integrating socio-cultural factors into predictive modelling. So far, predictive modelling has largely neglected the social and cultural dimensions of past landscapes. To maintain its value for archaeological research, therefore, it needs new methodologies, concepts and theories. For this study, we have departed from the methodology developed in the 1990s during the Archaeomedes Project. In this project, cross-regional comparisons of settlement location factors were made by analyzing the environmental context of Roman settlements in the French Rhône Valley. For the current research, we expanded the set of variables…
L'enquête sur les archives de la recherche en sciences humaines et sociales (ARSHS). Premier bilan
2009
Le reperage, la collecte et la conservation des archives produites par la recherche en sciences humaines et sociales sont une preoccupation recente en France. Cet article presente une experience originale menee par le reseau des Maisons des sciences de l’homme en collaboration avec les Archives nationales et le ministere de l’Enseignement superieur aupres des archives et des centres de recherche (universites, CNRS) pour faire un inventaire des archives de la recherche. Outre le sauvetage de fonds en perdition, l’enquete vise a sensibiliser les chercheurs a la conservation des donnees qu’ils produisent et a rendre possible une histoire des pratiques de recherche et une histoire sociale des s…
Intégrer la connectivité paysagère dans la séquence ERC : une approche par la quantité d'habitat atteignable
2019
Des engagements nationaux, européens et internationaux ont été pris pour maintenir et restaurer la connectivité entre habitats naturels face à la perte et à la fragmentation de ces habitats. Dans le même temps, les politiques environnementales dans différents pays mettent en oeuvre la séquence Eviter-Réduire-Compenser (ERC) pour atteindre l’objectif d’absence de perte nette de biodiversité (PPN). La séquence ERC a pour principe d’évaluer l’ensemble des impacts écologiques d’un aménagement, mais les critères et indicateurs permettant de quantifier les impacts sur la connectivité paysagère ne sont pas satisfaisants. Nous proposons une démarche opérationnelle pour évaluer les impacts environne…
Making sense of big data in health research: {T}owards an {EU} action plan
2016
Genome medicine 8(1), 71 (2016). doi:10.1186/s13073-016-0323-y
Red wine extract disrupts Th17 lymphocyte differentiation in a colorectal cancer context
2020
International audience; Scope: Scope: It is well established that immune response and inflammation promote tumoral progression. Immune cells communicate through direct contact or through cytokine secretion, and it is the pro-inflammatory status that will tip the balance toward tumor progression or anti-tumor immunity. It is demonstrated here that a red wine extract (RWE) can decrease inflammation through its action on the inflammasome complex. This study determines whether an RWE could impact other key actors of inflammation, including T helper 17 (Th17) immune cells in particular. Methods and results: Methods and results: Using an RWE containing 4.16 g of polyphenols/liter of wine, it is s…
Neurodegeneration in tauopathies and synucleinopathies.
2016
International audience; While increasing life expectancy is a major achievement, the global aging of societies raises a number of medical issues, such as the development of age-related disorders, including neurodegenerative diseases. The three main disease groups constituting the majority of neurodegenerative diseases are tauopathies, alpha-synucleinopathies and diseases due to repetitions of glutamine (including Huntington's disease). In each neurodegenerative disease, the accumulation of one or more aggregated proteins has been identified as the molecular signature of the disease (as seen, for example, in Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies, amyotrophic lat…
Oestrus ovis external ophtalmomyiasis : a case report in Burgundy France
2018
Background External ophtalmomyiasis (EOM) is a zoonosis related to the presence of Oestrus ovis larvae at the ocular level in small ruminants (i.e. ovine, caprine). In humans, EOM is a rare cosmopolitan disorder, mostly described in warm and dry rural areas in patients living close to livestock areas. In metropolitan France (excluding Corsica), EOM is an exceptional disease with less than 25 cases recorded since 1917. Case presentation We report a case of EOM in a 19-years old man in the last week of September 2016 in Burgundy. Conclusion The diagnosis of an EOM in Burgundy, a French region described as cold and humid, is surprising and could be due to a more marked climatic warming during …
Associations between food consumption patterns and saliva composition: Specificities of eating difficulties children
2017
Identifying objective markers of dietwould be beneficial to research fields such as nutritional epidemiology. As a preliminary study on the validity of using saliva for this purpose, and in order to explore the relationship between saliva and diet, we focused on clearly contrasted groups of children: children with eating difficulties (ED) receiving at least 50% of their energy intake through artificial nutrition vs healthy controls (C). Saliva of ED and C children was analyzed by various methods (targeted biochemical analyses, 2-D electrophoresis coupled to MS, 1H NMR) and their diet was characterized using food frequency questionnaires, considering 148 food items grouped into 13 categories…
Vaccinia-based oncolytic immunotherapy Pexastimogene Devacirepvec in patients with advanced hepatocellular carcinoma after sorafenib failure: a rando…
2019
PMC6682346; Pexastimogene devacirepvec (Pexa-Vec) is a vaccinia virus-based oncolytic immunotherapy designed to preferentially replicate in and destroy tumor cells while stimulating anti-tumor immunity by expressing GM-CSF. An earlier randomized Phase IIa trial in predominantly sorafenib-naive hepatocellular carcinoma (HCC) demonstrated an overall survival (OS) benefit. This randomized, open-label Phase IIb trial investigated whether Pexa-Vec plus Best Supportive Care (BSC) improved OS over BSC alone in HCC patients who failed sorafenib therapy (TRAVERSE). 129 patients were randomly assigned 2:1 to Pexa-Vec plus BSC vs. BSC alone. Pexa-Vec was given as a single intravenous (IV) infusion fol…